著者

Jun Tanimura Hiromi Nakagawa Takeo Tanaka Akihiro Kikuchi Sachie Osada Yoshiaki Tanaka Kumpei Tokuyama Toshinari Takamura

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.66, no.7, pp.615-620, 2019 (Released:2019-07-28)

参考文献数

11

被引用文献数

9 11

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The mechanistic target of rapamycin (mTOR) inhibitor everolimus is an antitumor agent known to cause hyperglycemia. However, the clinical course of everolimus-induced hyperglycemia, its pathophysiological basis, and the treatment strategy are not clear. In this case series report, we present the clinical course of everolimus-induced hyperglycemia in four patients. Hyperglycemia occurred 3–8 weeks after the administration of everolimus irrespective of the body mass index (range, 21.3–29.1 kg/m2) or pre-existing diabetes. Insulin or insulin secretagogues were required for glycemic control in most of the patients. Of note, the hyperglycemia was reversible in all patients, and none of the patients required anti-diabetic agents to achieve adequate glycemic control after cessation of everolimus therapy. To investigate the underlying mechanism of everolimus-induced hyperglycemia, we assessed insulin secretion and sensitivity by 75 g oral glucose tolerance test, arginine challenge test, and/or hyperinsulinemic-euglycemic clamp study using stable isotope-labeled glucose tracer in two patients. Everolimus did not affect insulin sensitivity in the liver, skeletal muscle, or the adipose tissue. In contrast, everolimus impaired insulin secretion and thereby increased basal hepatic glucose production. These findings further our understanding of the role of mTOR in glucose homeostasis in humans and provide insights for treatment strategies against everolimus-induced hyperglycemia.

著者

Kaito Iwayama Kumpei Tokuyama

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.1, no.2, pp.307-316, 2012-07-25 (Released:2012-09-11)

参考文献数

56

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Indirect calorimetry with a room-size respiratory chamber provides an ideal setting to monitor energy metabolism for a prolonged period. During the last 10 years, experiments with this method have raised interesting observations such as: 1) exercise intensity has no effect on 24 h fat oxidation, 2) exercise has little, if any, effect on 24 h fat oxidation, and 3) exercise before breakfast increases 24 h fat oxidation. To some of the scientific community and general public, the first two statements may be unacceptable. But it can be factually explained that the impact of exercise on energy metabolism is not confined to the period of physical activity itself, and that fat oxidation remains elevated during the post-exercise period. The third observation seems to be insignificant, but contradicts the second one. It is premature to conclude that exercise has no effect on 24 h fat oxidation.

著者

Akiko UCHIZAWA Airi FUNAYAMA Haruka OSUMI Yasushi ENOMOTO Simeng ZHANG Kumpei TOKUYAMA Naomi OMI Hiroyuki SAGAYAMA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.1, pp.47-54, 2022-02-28 (Released:2022-02-28)

参考文献数

43

被引用文献数

3

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The food quotient (FQ), which is the rate of macronutrient composition calculated from daily meals, can equal the respiratory quotient over a long term. The FQ is needed to estimate the total energy expenditure (TEE) in doubly labeled water studies. Usually, dietary records (DR) are used for dietary assessment in clinical nutritional studies; however, the DR method’s disadvantage is that it takes time to calculate the results. In comparison, the food frequency questionnaires (FFQ) method is a simple and quick way to calculate results. This study aimed to assess the FQ in Japanese runners, and to compare the two dietary assessment methods, DR and FFQ, to examine whether FFQ is useful in calculating the FQ in healthy young adults and runner. The study consisted of 27 runners and 22 healthy young adults. The participants recorded and took pictures all their meals for 1 wk and provided the FFQ for the same week. The FQ was calculated using the proportions of proteins, fats, carbohydrates, and alcohol. There were no significant differences between the FQs of the runners 0.867 (male: 0.873, female: 0.863) and the healthy young adults 0.871 (male: 0.875, female: 0.867) according to the DR methods. There were no differences in the FQs between DR and FFQ methods for all groups. A significant correlation between the FQs (r=0.502, p<0.01), estimated using the DR, and the FQs estimated using the FFQ was observed. These results suggest that use of the FFQ method can provide comparable data for runners and healthy young adults.