著者

Masaya Iwamuro Takehiro Tanaka Sakiko Kuraoka Kenta Hamada Makoto Abe Yoshiyasu Kono Hiromitsu Kanzaki Seiji Kawano Yoshiro Kawahara Hiroyuki Okada

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.13, pp.1931-1938, 2022-07-01 (Released:2022-07-01)

参考文献数

16

被引用文献数

3

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Objective This study aimed to determine the prevalence and endoscopic features of zinc acetate dihydrate tablet-associated gastric lesions. Methods We retrospectively examined the endoscopic features of 47 patients taking zinc acetate dihydrate tablets who underwent esophagogastroduodenoscopy. Results Gastric mucosal alterations, including redness, erosions, ulcers, and adhesion of the white coat, were observed in 29 of 47 patients (61.7%). Among patients with gastric lesions (group A), there was a significantly higher percentage of symptomatic patients in comparison to patients without lesions (group B) (65.5% vs. 22.2%; p<0.01). The background characteristics of the two groups did not differ to a statistically significant extent. On esophagogastroduodenoscopy, mucosal redness (n=27, 93.1%), erosions (n=26, 90.0%), adhesion of the white coat (n=25, 86.2%), and ulcers (n=9, 31.0%) were observed. None of the 19 patients who previously underwent esophagogastroduodenoscopy had gastric lesions before starting zinc acetate dihydrate. Esophagogastroduodenoscopy was performed after the cessation of zinc acetate dihydrate intake in six patients, and revealed the resolution of gastric lesions. Conclusion Gastric lesions were observed in 29 of 47 patients who were taking zinc acetate dihydrate tablets. The most common endoscopic findings were mucosal redness (93.1%), erosions (90.0%), adhesion of the white coat (86.2%), and ulcers (31.0%). Although the exact pathogenesis is uncertain, we believe that understanding the unique manifestations of this gastric lesion will help physicians manage adverse events in patients taking zinc acetate dihydrate tablets.

著者

Shunsuke Tamaki Yoshihiro Sato Takahisa Yamada Takashi Morita Yoshio Furukawa Yusuke Iwasaki Masato Kawasaki Atsushi Kikuchi Takumi Kondo Tatsuhisa Ozaki Masahiro Seo Iyo Ikeda Eiji Fukuhara Makoto Abe Jun Nakamura Masatake Fukunami

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-1122, (Released:2017-02-16)

参考文献数

39

被引用文献数

34

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Background:Although the mainstay of treatment for acute decompensated heart failure (ADHF) is decongestion by diuretic therapy, it is often associated with worsening renal function (WRF). The effect of tolvaptan, a selective V2 receptor antagonist, on WRF in ADHF patients with preserved left ventricular ejection fraction (LVEF) is unknown.Methods and Results:We enrolled 50 consecutive ADHF patients whose LVEF on admission was ≥45%. Patients were randomly assigned to either tolvaptan add-on (n=26) or conventional diuretic therapy (n=24). The primary endpoint was the incidence of WRF, defined as an increase in serum creatinine (Cr) ≥0.3 mg/dL or 50% above baseline within 48 h of randomization. There was no significant difference between the 2 groups in the change in body weight or the total urine volume during 48 h. However, the change in Cr (∆Cr) at 24 and 48 h after randomization and the incidence of WRF (12% vs. 42%, P=0.0236) were significantly lower, and the fractional excretion of urea (FEUN) at 24 and 48 h after randomization was significantly higher in the tolvaptan group. There was an inverse correlation between ∆Cr and FEUN at 48 h after randomization.Conclusions:Tolvaptan can alleviate congestion with a significantly lower risk of WRF in ADHF patients with preserved LVEF, presumably through maintenance of renal perfusion.

著者

阿部 誠 Makoto Abe 東京大学大学院経済学研究科・経済学部

出版者

日本統計学会

雑誌

日本統計学会誌 = Journal of the Japan Statistical Society (ISSN:03895602)

巻号頁・発行日

vol.29, no.3, pp.271-297, 1999-12-01

参考文献数

35

被引用文献数

1 2

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多項ロジット型の離散的選択モデル(Multinomial Logit Model of Discrete Choice)の効用関数に使われる説明変数は通常, 線型または関数変換後の和として設定されるが, この研究では効用関数を個々の説明変数による1次元のノンパラメトリック関数の和とし, 変数の非線的な反応をよりフレキシブルに推測する.このモデルは二項従属変数を対象とするGeneralized Additive Modelsによるロジスティック回帰(logistic regression)を一般化し, 3つ以上の値をとる多項従属変数に対処する.シミュレーションによると, 様々に設定された変数の非線型反応が復元された.このモデルの応用として, スーパーマーケットからバーコード・スキャナーで収集された2種類の商品カテゴリーの世帯別購買パネルデータを用いて, 消費者がマーケティング変数にどのような非線型的反応をしているかを検討した.また, マモグラム経験の医学データにも当てはめられて, モデル構築と診断にどのように役立つかを示した.