著者

Jun Nakamura Takao Nagashima Yoichiro Akiyama Seiji Minota

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.58, no.3, pp.455, 2019-02-01 (Released:2019-02-01)

被引用文献数

2 3

著者

Shunsuke Tamaki Yoshihiro Sato Takahisa Yamada Takashi Morita Yoshio Furukawa Yusuke Iwasaki Masato Kawasaki Atsushi Kikuchi Takumi Kondo Tatsuhisa Ozaki Masahiro Seo Iyo Ikeda Eiji Fukuhara Makoto Abe Jun Nakamura Masatake Fukunami

出版者

日本循環器学会

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-16-1122, (Released:2017-02-16)

参考文献数

39

被引用文献数

34

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Background:Although the mainstay of treatment for acute decompensated heart failure (ADHF) is decongestion by diuretic therapy, it is often associated with worsening renal function (WRF). The effect of tolvaptan, a selective V2 receptor antagonist, on WRF in ADHF patients with preserved left ventricular ejection fraction (LVEF) is unknown.Methods and Results:We enrolled 50 consecutive ADHF patients whose LVEF on admission was ≥45%. Patients were randomly assigned to either tolvaptan add-on (n=26) or conventional diuretic therapy (n=24). The primary endpoint was the incidence of WRF, defined as an increase in serum creatinine (Cr) ≥0.3 mg/dL or 50% above baseline within 48 h of randomization. There was no significant difference between the 2 groups in the change in body weight or the total urine volume during 48 h. However, the change in Cr (∆Cr) at 24 and 48 h after randomization and the incidence of WRF (12% vs. 42%, P=0.0236) were significantly lower, and the fractional excretion of urea (FEUN) at 24 and 48 h after randomization was significantly higher in the tolvaptan group. There was an inverse correlation between ∆Cr and FEUN at 48 h after randomization.Conclusions:Tolvaptan can alleviate congestion with a significantly lower risk of WRF in ADHF patients with preserved LVEF, presumably through maintenance of renal perfusion.

著者

Jun Nakamura Takao Nagashima Taku Yoshio Seiji Minota

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.6, pp.689-689, 2015 (Released:2015-03-15)

著者

Takeo Horikoshi Takamitsu Nakamura Toru Yoshizaki Jun Nakamura Manabu Uematsu Tsuyoshi Kobayashi Yukio Saito Jun-ei Obata Takao Sawanobori Hajime Takano Ken Umetani Tetsuya Asakawa Akira Sato

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-23-0733, (Released:2023-12-15)

参考文献数

22

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Background: Non-ST-elevation myocardial infarction (NSTEMI) carries a poor prognosis, and accurately prognostication has significant clinical importance. In this study, we analyzed the predictive value of the CHADS2, CHA2DS2-VASc, and R2-CHADS2scores for major adverse cardiac events (MACE) following percutaneous coronary intervention (PCI) in patients with NSTEMI using data from a prospective multicenter registry.Methods and Results: The registry included 440 consecutive patients with NSTEMI and coronary artery disease who underwent successful PCI. Patients were clinically followed for up to 3 years or until the occurrence of MACE. MACE was defined as a composite of all-cause death and nonfatal MI. During the follow-up period, 55 patients (12.5%) experienced MACE. Risk analysis of MACE occurrence, adjusted for the multivariable model, demonstrated a significant increase in risk with higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores. Kaplan-Meier analysis showed a higher incidence of MACE in patients with higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores, both in the short- and long-term periods.Conclusions: Patients with NSTEMI and higher CHADS2, CHA2DS2-VASc, and R2-CHADS2scores displayed a greater incidence of MACE.

著者

Jun Nakamura

出版者

The International Academy of Strategic Management

雑誌

Journal of Strategic Management Studies (ISSN:18839843)

巻号頁・発行日

vol.12, no.1, pp.27-40, 2020-10-30 (Released:2020-10-30)

参考文献数

39

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It has been a while since Japanese enterprises experienced downturns and faced issues due to low profitability. In the field of software, it is generally acknowledged that open source concepts are desirable in terms of both cost reduction and effectiveness. However, companies tend to have a certain degree of ‘psychological resistance’ to the use of open source tools. In comparison to western enterprises, Japanese businesses lag far behind in this regard.Therefore, referring to the case of Google, the author analyzed how open source can be used as an open strategy based on a framework comprising strategy and resources (capability). The author found that Google adopts both open and closed strategies. The open strategy makes sure that Google can thoroughly utilize contributions, and this provides a mechanism by which stakeholders can reduce costs and use Google apps without transferring money along the supply chain. The closed strategy clarifies which elements can be differentiated to maintain market competitivity and concentrates profit sources in these areas.The implication of this is that Google ambidextrously uses both open and closed strategies, and that the management responsible for the realization of these strategies is functioning well. In other words, the business model promoted by Google is admirable, comprehensively using both platform and dynamic capability strategies, thus combining sources of revenue and resources to make the most effective use of open source.

著者

Jun-ichi Takahashi Shin-ichi Akimoto Eisuke Hasegawa Jun Nakamura

出版者

JAPANESE SOCIETY OF APPLIED ENTOMOLOGY AND ZOOLOGY

雑誌

Applied Entomology and Zoology (ISSN:00036862)

巻号頁・発行日

vol.37, no.3, pp.481-486, 2002 (Released:2003-04-25)

参考文献数

29

被引用文献数

12 14

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Vespa ducalis is a monogynous hornet with an annual life cycle. Its colonies are the smallest in the genus Vespa. Generally, it is thought that the number of queen matings and colony size are positively correlated, so we analyzed the queen mating number and genetic relatedness between workers of V. ducalis using microsatellite DNA markers. We examined foundress queens and 20 workers from each of 20 colonies. All colonies were found to have one queen inseminated by one male. The genetic relatedness between workers was 0.724±0.0029 (mean±SE), which is not significantly different from the expected value of 0.75 for full sisters. This result suggests a possible conflict in male production between queens and workers based on kin selection prediction. Therefore, we performed microsatellite analysis of 400 males from 20 colonies to verify whether males are derived from either queens or from workers. No males could be assigned to workers developed ovaries were not found in a total of 880 mature workers. These results strongly suggest that queens dominate production of males in V. ducalis colonies.