著者

Haruyo IWASAWA Masatoshi YAMAZAKI

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.15, no.3, pp.275-282, 2009 (Released:2009-08-06)

参考文献数

17

被引用文献数

2 9

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We have studied the neutrophil-increasing effects of fruits and vegetables and their priming effects on cytokine induction. Among fruits, bananas exhibited the most marked priming effects. Therefore, we evaluated possible differences in the biological response modifier (BRM)-like activities of bananas (such as the effects on neutrophil accumulation and macrophage morphology, and the priming effects on cytokine induction), according to their strain and maturity, using a conventional strain and a strain for highland cultivation. As a result, the total intraperitoneal leukocyte count and % neutrophils increased in parallel with the concentration and maturity of banana extracts. These effects were more marked in the highland strain. After the addition of banana extracts, marked macrophage spreading was observed, and morphological changes differed according to the strain and maturity of bananas. The priming effects on TNF-α or IL-12 induction also differed according to the maturity and strain of bananas, and could also be confirmed after oral administration. These results suggest that banana intake is associated with various BRM-like activities, and these effects differ according to the maturity level of the bananas.

著者

Haruyo Iwasawa Erika Morita Satoru Yui Masatoshi Yamazaki

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.1, pp.128-134, 2011-01-01 (Released:2011-01-01)

参考文献数

41

被引用文献数

30 52 14

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We previously reported that kiwi fruit is rich in polyphenols and has immunostimulatory activity. Polyphenols are widely known for having anti-oxidant effects. We also revealed potential anti-oxidant effects of kiwi fruit in vivo by oral administration to mice. Here, we compared the anti-oxidant effects of kiwi fruit with those of other fruits in vitro. Then, we examined the inhibitory effects of kiwi fruit on oxidation in the human body. There are two varieties of kiwi fruit, green kiwi and gold kiwi. We also examined variation between these varieties. Comparison of the anti-oxidant effects in vitro demonstrated that kiwi fruit had stronger anti-oxidant effects than orange and grapefruit, which are rich in vitamin C; gold kiwi had the strongest anti-oxidant effects. Kiwi fruit inhibited oxidation of biological substances in the human body. In particular, kiwi fruit may inhibit early lipid oxidation. In this study, kiwi fruit had strong anti-oxidant effects and may prevent the development and deterioration of diseases caused by oxidative stress.

著者

Hiroshi Ueda Chikako Yamazaki Masatoshi Yamazaki

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.25, no.9, pp.1197-1202, 2002 (Released:2002-09-01)

参考文献数

24

被引用文献数

169 207

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Oral administration of the perilla leaf extract (PLE) to mice inhibits inflammation, allergic response, and tumor necrosis factor-α production. We also found that PLE suppressed the tumor necrosis factor-α (TNF-α) production in vitro. Using the inhibitory activity of TNF-α production in vitro as the index for isolation, we searched the active constituents from PLE and isolated luteolin, rosmarinic acid and caffeic acid as active components. Among the isolated compounds, only luteolin showed in vivo activity: inhibition of serum tumor necrosis factor-α production, inhibition of arachidonic acid-induced ear edema, inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced ear edema and inhibition of oxazolone-induced allergic edema. These results suggest that luteolin is a genuinely active constituent which is accountable for the oral effects of perilla.