著者

Masayuki UCHIDA Orie KOBAYASHI

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

pp.130319, (Released:2013-09-07)

被引用文献数

15

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We have reported an inhibitory effect of Lactobacillus gasseri OLL2809 (OLL2809) on the growth of mouse endometrial tissue in the abdominal cavity. The present study aimed to investigate the efficacy of Lactobacillus gasseri OLL2809 (OLL2809) on pre-existing endometriosis implanted on the abdominal wall in diestrus Wistar-Imamichi female rats. One week after implantation, the volume of the endometrial tissue was measured after laparotomy. OLL2809 and dienogest were administered for 4 weeks. OLL2809 significantly enhanced the decrease in the volume (p<0.01) as compared with control. Complete healing was observed in two of nine rats, but in none of the control group. Dienogest did not show significant efficacy. These findings suggest that OLL2809 is useful not only in therapy of pre-existing endometriosis but also in the prevention of the growth of endometrial tissue.

著者

村田 奈津子 藤森 志保 市原 叔立 佐藤 義男 山地 健人 坪井 洋 内田 勝幸 鈴木 啓仁 山田 昌司 根本 英雄 延廣 順子 町支 臣成 日比野 俐 ムラタ ナツコ フジモリ シホ イチハラ ヨシタツ サトウ ヨシオ ヤマジ タケト ツボイ ヒロシ ウチダ マサユキ スズキ ヒロト ヤマダ マサシ ネモト ヒデオ ノブヒロ ジュンコ チョウシ トミナリ ヒビノ サトシ Natsuko Murata Shiho Fujimori Yoshitatu Ichihara Yoshio Sato Taketo Yamaji Hiroshi Tsuboi Masayuki Uchida Hiroto Suzuki Masashi Yamada Hideo Nemoto Junko Nobuhiro Tominari Choshi Satoshi Hibino

雑誌

福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University

巻号頁・発行日

vol.25, 2007