6 0 0 0 OA ニューロパチーの診断と治療―日常診療でよく見る疾患を中心に―
- 著者
- 鈴木 美紀 竹内 恵 内山 真一郎 Miki SUZUKI Megumi TAKEUCHI Shinichiro UCHIYAMA
- 出版者
- 東京女子医科大学学会
- 雑誌
- 東京女子医科大学雑誌 (ISSN:00409022)
- 巻号頁・発行日
- vol.84, no.臨時増刊1(医学部神経内科学教室 内山真一郎教授退任記念特別), pp.E73-E79, 2014-01-31
1 0 0 0 OA Identification of a putative syncytin gene in a non-rodent laboratory mammal, Suncus murinus
- 著者
- Miki SUZUKI Akihiro NAKAMURA Yu MATSUMOTO Woojin KANG Minoru ICHINOSE Natsuko KAWANO Mitsutoshi YAMADA Miyuki SHINDO Daiki KATANO Takako SAITO Yuichirou HARADA Mami MIYADO Kenji MIYADO
- 出版者
- JAPANESE SOCIETY OF VETERINARY SCIENCE
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.22-0555, (Released:2023-07-12)
An endogenous retrovirus-derived membrane protein, syncytin (SYN), contributes to placental function via trophoblast fusion. Multinuclear trophoblasts (syncytiotrophoblasts) physically and functionally mediate the interaction between fetal and maternal vessels in various ways. Suncus murinus (suncus) is a small mammalian species with a pregnancy duration of approximately 30 days, 1.5 times longer than mice. However, the molecular basis for the longer pregnancy duration is unknown. In this study, we first isolated two putative Syn genes that were expressed in the suncus placenta. In this study, we first isolated two Syn genes that encoded putative SYN proteins expressed in the suncus placenta, which were named syncytin-1 (SYN-1)-like proteins 1 and 2. When their expression vectors were introduced into cultured cells, suncus SYN1L2 was found to be active in cell fusion. Moreover, the SYN1L2 protein was homologous to a SYN1-like protein identified in greater mouse-eared bats (bat SYN1L) and was structurally compared with bat SYN1L and other SYN proteins, implying the presence of structural features of the SYN1L2 protein.