- 著者
-
Kazuhide Inage
Takeshi Sainoh
Takayuki Fujiyoshi
Otagiri Takuma
Yasuchika Aoki
Masahiro Inoue
Yawara Eguchi
Sumihisa Orita
Yasuhiro Shiga
Masao Koda
Tsutomu Akazawa
Takeo Furuya
Junichi Nakamura
Hiroshi Takahashi
Miyako Suzuki
Satoshi Maki
Hideyuki Kinoshita
Masaki Norimoto
Tomotaka Umimura
Takashi Sato
Masashi Sato
Masahiro Suzuki
Keigo Enomoto
Hiromitsu Takaoka
Norichika Mizuki
Takashi Hozumi
Ryuto Tsuchiya
Geundong Kim
Tomohito Mukaihata
Takahisa Hishiya
Seiji Ohtori
- 出版者
- The Japanese Society for Spine Surgery and Related Research
- 雑誌
- Spine Surgery and Related Research (ISSN:2432261X)
- 巻号頁・発行日
- pp.2020-0042, (Released:2020-07-10)
- 被引用文献数
-
3
Introduction: Mirogabalin should be equivalent to pregabalin, but with fewer incidences of adverse drug reactions (ADRs). To verify these benefits in actual clinical trials, our study investigated the frequency of ADRs and mirogabalin' s analgesic effects during treatment of peripheral neuropathic pain.Methods: This study included 74 patients with lower limb pain. We surveyed patient reports of ADRs during the follow-up period as the primary endpoint and examined the visual analog scale (VAS) reported for lower limb pain as the secondary endpoint (before administration, and two and four weeks after administration).Results: The occurrence of ADR was 27.0%, like the frequency of ADRs in the clinical trials for other disorders. However, the discontinuation rate of administration was 10.8%, which was significantly lower than the frequency of ADR occurrences. When the analgesic effect was assessed, a significant decrease in the temporal change of VAS for lower limb pain was observed before administration, and two and four weeks after administration.Conclusions: In this study, the occurrence of ADRs reported by the patients was like the frequency of ADRs reported in the clinical trials for other disorders. When assessing the analgesic effect, the temporal change of VAS for lower limb pain was found to decrease significantly before administration, and two and four weeks after administration.