Allergic reactions to iodine contrast agent rarely lead to anaphylactic shock affecting hemodynamics. We treated two cases of anaphylactic shock during coronary angiography, which did not respond to adrenaline because thepatients had taken beta-blockers. Instead, glucagon relieved their conditions. If patients treated with beta-blockersexperience anaphylactic shock during coronary angiography, we should consider glucagon as a treatment optionbecause the persistence of shock refractory to adrenaline leads to unfavorable outcomes.