著者

成橋 和正 藏所 志穂 中村 憲夫 NARUHASHI Kazumasa KURASHO Shiho NAKAMURA Norio

出版者

京都

雑誌

総合文化研究所紀要 = Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts (ISSN:09100105)

巻号頁・発行日

vol.38, pp.135-141, 2021-07-29

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Drug therapy with steroids and moisturizers is highly effective for the treatment of atopic dermatitis, but the use of steroids is dependent on the stage of the patient’s disease. Shiunkou is a Kampo topical ointment with a purple tinge called shicon. It has been reported to be used clinically in combination with a moisturizer; however its stability has not been described. In this study, we investigated the stability of Shiunkou and Hirudoid Soft Ointment when mixed. The simplest method for measuring stability is to observe changes in appearance. The mixed ointment did not change during refrigerated storage for up to 7 months. When stored at room temperature, oil separation occurred after the first month, and became more remarkable with time, such as at 3 months and 7 months. It has been shown that the ointment mixture should be stored refrigerated rather than stored at room temperature. When the stability of shicon, which is an active ingredient of Shiunkou, was examined in an aqueous solution, it decomposed very quickly regardless of the pH. Hirudoid Soft Ointment is a w/o preparation and contains water. When the ointment is mixed, and shicon, a the component of Shiunkou, comes into contact with the water contained in the Hirudoid Soft Ointment, there is a concern that the content of shicon in the ointment mixture may decrease, even if by a small amount or for a short time.