7 0 0 0 31C-07 桂皮含有タンニンにおける内皮依存性血管弛緩作用
2 0 0 0 OA 睡眠調節物質オキシピナタニンの作用メカニズムの解明
オキシピナタニンは,マウスの腹腔内および経口投与後の脳波測定により、経口投与においてのみ睡眠量の増加が認められた。また、血中濃度の検討で,経口投与時の血中濃度は非常に低いことがわかった。オキシピナタニンは体内で代謝を受け、作用する可能性が判明した。人工胃液,人工腸液での安定性、肝臓での代謝の検討から,胃、腸および肝臓で代謝されていないことがわかった。更に、サーモグラフィーを用いた体温測定により、オキシピナタニンは末梢血管の拡張作用に伴う熱放出により、睡眠改善効果を示す可能性が示唆された。
1 0 0 0 OA 紫雲膏とヒルドイドソフト軟膏の混合軟膏の外観変化による安定性の評価と配合変化に関する考察
- 著者
- 成橋 和正 藏所 志穂 中村 憲夫 NARUHASHI Kazumasa KURASHO Shiho NAKAMURA Norio
- 出版者
- 京都
- 雑誌
- 総合文化研究所紀要 = Bulletin of Institute for Interdisciplinary Studies of Culture Doshisha Women’s College of Liberal Arts (ISSN:09100105)
- 巻号頁・発行日
- vol.38, pp.135-141, 2021-07-29
Drug therapy with steroids and moisturizers is highly effective for the treatment of atopic dermatitis, but the use of steroids is dependent on the stage of the patient’s disease. Shiunkou is a Kampo topical ointment with a purple tinge called shicon. It has been reported to be used clinically in combination with a moisturizer; however its stability has not been described. In this study, we investigated the stability of Shiunkou and Hirudoid Soft Ointment when mixed. The simplest method for measuring stability is to observe changes in appearance. The mixed ointment did not change during refrigerated storage for up to 7 months. When stored at room temperature, oil separation occurred after the first month, and became more remarkable with time, such as at 3 months and 7 months. It has been shown that the ointment mixture should be stored refrigerated rather than stored at room temperature. When the stability of shicon, which is an active ingredient of Shiunkou, was examined in an aqueous solution, it decomposed very quickly regardless of the pH. Hirudoid Soft Ointment is a w/o preparation and contains water. When the ointment is mixed, and shicon, a the component of Shiunkou, comes into contact with the water contained in the Hirudoid Soft Ointment, there is a concern that the content of shicon in the ointment mixture may decrease, even if by a small amount or for a short time.