著者

Koichi Sagawa Tsugutoshi Suzuki Kohta Takei Masaru Miura Hideaki Ueda Hitoshi Horigome Hiroshi Ono Naoki Ohashi Seiichi Sato Hideo Fukunaga Hisaaki Aoki Aya Miyazaki Heima Sakaguchi Eiichiro Morishima Kaori Oki Naokata Sumitomo

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-21-0967, (Released:2022-08-18)

参考文献数

30

被引用文献数

1

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Background: The prospective Control of HEART rate in inFant and child tachyarrhythmia with reduced cardiac function Using Landiolol (HEARTFUL) study investigated the effectiveness and safety of landiolol, a short-acting β1 selective blocker, in children.Methods and Results: Twenty-five inpatients aged ≥3 months to <15 years who developed supraventricular tachyarrhythmias (atrial fibrillation, atrial flutter, supraventricular tachycardia, and inappropriate sinus tachycardia) were treated with landiolol. The primary endpoint, the percent of patients with a reduction in heart rate ≥20% from the initial rate of tachycardia, or termination of tachycardia at 2 h after starting landiolol, was achieved in 12/25 patients (48.0%; 95% CI 28.4–67.6), which exceeded the predetermined threshold (38.0%). At 2 h after starting landiolol administration, heart rate had decreased by ≥20% in 45.8% (11/24) and recovery to sinus rhythm was achieved in 40.0% (6/15) of the patients. Adverse reactions (ARs) occurred in 24.0% (6/25) of patients, and the study was discontinued in 4.0% (1/25) of the patients; however, none of these ARs were considered serious. The most common AR was hypotension (20.0% [5/25] of patients).Conclusions: The HEARTFUL study has demonstrated the efficacy of landiolol, by reducing heart rate or terminating tachycardia, in pediatric patients with supraventricular tachyarrhythmias. Although serious ARs and concerns were not identified in this study, physicians should be always cautious of circulatory collapse due to hypotension.

著者

Kota Hasegawa Takao Shimizu Naoki Ohashi

出版者

The Ceramic Society of Japan

雑誌

Journal of the Ceramic Society of Japan (ISSN:18820743)

巻号頁・発行日

vol.130, no.7, pp.452-457, 2022-07-01 (Released:2022-07-01)

参考文献数

42

被引用文献数

2

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The density functional theory (DFT) was employed to understand the ferroelectric behaviors of wurtzite (WZ)-type aluminum nitride (AlN). To explain the decrease in the coercive field (Ec) due to lattice deformation, the total energy and enthalpy of the strained WZ phase were compared to those of the non-polar (NP) phase, which acted as a transition state during polarity switching. The shrinkage of the c-axis length and elongation of the a-axis length were favorable for reducing Ec. In addition, the calculated residual stress in the transient NP phase was as high as 30 GPa, suggesting that such a high residual stress may be related to the polarity switching behavior under a very high electric field.