- 著者
- Yasuko Manabe Nobuharu L. Fujii
- 出版者
- 一般社団法人日本体力医学会
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.5, no.5, pp.373-377, 2016-11-25 (Released:2016-11-10)
- 参考文献数
- 26
- 被引用文献数
- 3
Skeletal muscle has an important role besides its obvious function in physical movement and locomotion; namely, it maintains whole-body metabolism. Maintaining muscle mass and quality with regular exercise is closely related to quality of life and a healthy life expectancy. However, the ways that exercise, and muscle contraction, in particular, contribute to our health has not been analyzed in detail. Progressive elucidation of the intracellular mechanisms underlying the metabolic changes induced by exercise/contraction and the hormones secreted from skeletal muscle (called myokines) is providing new insights into how exercise affects our health. To research these mechanisms in muscle contraction, various in vivo and in vitro experimental models have been developed. This review article outlines the existing skeletal muscle contraction models in rodents. Each model has its advantages and disadvantages. It is important to keep such features in mind when selecting an appropriate contraction model for the particular experimental purpose.
- 著者
- Yasuro Furuichi Nobuharu L. Fujii
- 出版者
- 一般社団法人日本体力医学会
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.6, no.5, pp.311-316, 2017-09-25 (Released:2017-09-29)
- 参考文献数
- 51
- 被引用文献数
- 4
Skeletal muscle stem cells, known as satellite cells, participate in postnatal skeletal muscle growth, regeneration, and hypertrophy. They are quiescent in the resting state, but are activated after muscle injury, and subsequently replicate and fuse into existing myofibers. The behavior of satellite cells during muscle regeneration is regulated by extrinsic factors, such as the extracellular matrix, mechanical stimuli, and soluble factors. Myokines, muscle-derived secretory factors, are important regulators of satellite cell activation, proliferation, and differentiation. It is well known that muscle injury induces the release of various growth factors from myofibers, and these growth factors affect satellite cells. It has recently been shown that myokines secreted from myofibers without cell damage also regulate satellite cell functions. Here, we summarize myokines with known roles in the regulation of satellite cells and the mechanism underlying this regulatory process.
- 著者
- Kotaro Tamura Yasuro Furuichi Yasuko Manabe Nobuharu L. Fujii
- 出版者
- 一般社団法人日本体力医学会
- 雑誌
- The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)
- 巻号頁・発行日
- vol.6, no.2, pp.89-93, 2017-03-25 (Released:2017-03-19)
- 参考文献数
- 41
- 被引用文献数
- 1
Satellite cells are resident muscle stem cells located between the basal lamina and the plasma membrane of myofibers. They play crucial roles in muscle growth during the postnatal stage and muscle regeneration following postnatal development. However, the roles of satellite cells in adult muscles - in muscle growth, function, and adaptation - are poorly understood. Recently, by studying genetically engineered mice with conditionally ablated satellite cells, it has been reported that satellite cells play important roles in muscle growth and maintenance of muscle spindles or neuromuscular junctions, and produce growth factors that affect other organs. Here, we review the recent studies using tamoxifen-inducible Pax7-DTA mice and describe the novel roles of satellite cells in the maintenance of skeletal muscle plasticity.