著者

Yasuko Manabe Nobuharu L. Fujii

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.5, no.5, pp.373-377, 2016-11-25 (Released:2016-11-10)

参考文献数

26

被引用文献数

3

---

Skeletal muscle has an important role besides its obvious function in physical movement and locomotion; namely, it maintains whole-body metabolism. Maintaining muscle mass and quality with regular exercise is closely related to quality of life and a healthy life expectancy. However, the ways that exercise, and muscle contraction, in particular, contribute to our health has not been analyzed in detail. Progressive elucidation of the intracellular mechanisms underlying the metabolic changes induced by exercise/contraction and the hormones secreted from skeletal muscle (called myokines) is providing new insights into how exercise affects our health. To research these mechanisms in muscle contraction, various in vivo and in vitro experimental models have been developed. This review article outlines the existing skeletal muscle contraction models in rodents. Each model has its advantages and disadvantages. It is important to keep such features in mind when selecting an appropriate contraction model for the particular experimental purpose.

著者

Yasuko MANABE Tohru FUSHIKI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.48, no.2, pp.81-88, 2002 (Released:2009-04-28)

参考文献数

113

被引用文献数

2 2

---

Taste plays an important role in the regulation of food and fluid intake in animals. Taste information on the tongue is transmitted to the brain, and we feel hedonic or aversive sensation from the taste of a food. Various studies have shown that opioids or the dopamigenic system is deeply related to the hedonic response in the brain. Few studies have been made, however, about the aversion to food, which is an important signal for animals to protect them from poison that usually has a bitter taste and causes an aversive sensation. We recently suggested that diazepam binding inhibitor (DBI) was released in the brain after stimulation by an aversive taste and might be involved in the aversive sensations of taste. In this review we describe the studies on aversive sensation after eating and propose a novel concept that food aversion may be divided into aversion and rejection. Furthermore, we suggest that DBI is involved in aversion.

著者

Kotaro Tamura Yasuro Furuichi Yasuko Manabe Nobuharu L. Fujii

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.6, no.2, pp.89-93, 2017-03-25 (Released:2017-03-19)

参考文献数

41

被引用文献数

1

---

Satellite cells are resident muscle stem cells located between the basal lamina and the plasma membrane of myofibers. They play crucial roles in muscle growth during the postnatal stage and muscle regeneration following postnatal development. However, the roles of satellite cells in adult muscles - in muscle growth, function, and adaptation - are poorly understood. Recently, by studying genetically engineered mice with conditionally ablated satellite cells, it has been reported that satellite cells play important roles in muscle growth and maintenance of muscle spindles or neuromuscular junctions, and produce growth factors that affect other organs. Here, we review the recent studies using tamoxifen-inducible Pax7-DTA mice and describe the novel roles of satellite cells in the maintenance of skeletal muscle plasticity.

著者

Yasuko Manabe Shouta Miyatake Mayumi Takagi

出版者

一般社団法人日本体力医学会

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.1, no.1, pp.51-58, 2012-05-25 (Released:2012-08-22)

参考文献数

89

被引用文献数

2 9

---

Skeletal muscle has only recently been considered a secretory organ. Muscle-derived proteins are now termed myokines. Until date, about 20 proteins known as cytokines, growth factors, and adipokines have been reported as myokines. However, only a few studies have been able to demonstrate secretion from the skeletal muscle. Furthermore, many reports are still uncertain of whether proteins are secreted from skeletal muscle cells or from the surrounding tissue, because some studies have measured myokine concentration in blood taken from human and animal subjects, which also contains other organ-derived proteins. Secretion of some myokines is promoted by muscle contraction or insulin stimulation, whereas others seem to be constitutively secreted. The mechanisms of action and roles of myokines are also complicated. Some are believed to affect distant organs through endocrine and paracrine mechanisms, while others affect organs through an autocrine mechanism. In this article, we review updates of myokines, including their history. Furthermore, the article discusses the need to re-define myokines in order to avoid possible misunderstandings because of insufficient data.