- 著者
- Kyosuke MATSUNAGA Shinjiro FUKAMI Nobuyuki NAKAJIMA Norio ICHIMASU Michihiro KOHNO
- 出版者
- The Japan Neurosurgical Society
- 雑誌
- NMC Case Report Journal (ISSN:21884226)
- 巻号頁・発行日
- vol.10, pp.309-314, 2023-12-31 (Released:2023-11-11)
- 参考文献数
- 11
Diffuse midline glioma (DMG), H3 K27M-altered, is a tumor with a poor prognosis mainly found in children. An adolescent patient presented with thalamic hemorrhage, which initially could not be diagnosed as DMG by pathological analysis. A neoplasm in the lateral ventricle close to the previous thalamic hemorrhagic lesion was detected 12 months after the hemorrhage. Thus, endoscopic resection was performed, and a diagnosis was made. Gene expression profiling demonstrated mutation in genes, such as H3F3A and FGFR1. FGFR1 mutation was associated with intratumoral hemorrhage in low-grade gliomas and contributed to longer survival than wild-type FGFR1 in DMG H3K27M. Our findings suggest that patients with DMG, H3 K27-altered, with FGFR1 mutation may be predisposed to intratumoral hemorrhaging and/or have a longer survival time than patients without FGFR1 mutation.
1 0 0 0 IR 大学生競技者のスポーツ傷害発生に関わる属性およびストレッサーの検討
- 著者
- 伊藤 詩織 中島 宣行 佐々木 万丈 Shiori Ito Nobuyuki Nakajima Banjou Sasaki
- 出版者
- 日本女子体育大学
- 雑誌
- 日本女子体育大学紀要 (ISSN:02850095)
- 巻号頁・発行日
- vol.45, pp.165-172, 2015-03
We investigated differences in the frequency of sports injuries between individual and team competition players and between males and females, and we also examined the influence of subjective evaluation of stressors on sports injury frequency. College athletes (N=133) were asked to complete a scale of daily and competitive stressors and to answer a questionnaire on the frequency of sports-related injuries. Chi-square analyses revealed that there were no differences in injury frequency between individual and team competitive players, but that male athletes had a significantly higher frequency of injuries than females. Simple regression analysis revealed that subjective evaluation of "competition results"and "expectations of, and pressure from, others"influenced the sports injury frequency.These results suggest that the frequency of sports injuries is associated with sex and with cognitive evaluation of competitive stressors.