著者

Tomoaki NAITO Masatoshi MORIKAWA Mayuko YAMAMOTO-FUJIMURA Akira IWATA Ayaka MAKI Noriko KATO-NAGAOKA Kosuke OANA Junko KIYOSHIMA-SHIBATA Yumi MATSUURA Rumi KAJI Osamu WATANABE Kan SHIDA Satoshi MATSUMOTO Tetsuji HORI

出版者

BMFH Press

雑誌

Bioscience of Microbiota, Food and Health (ISSN:21863342)

巻号頁・発行日

vol.42, no.1, pp.65-72, 2023 (Released:2023-01-01)

参考文献数

39

被引用文献数

1

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Mononuclear phagocytic cells (MPCs) are classified into monocytes (Mos)/macrophages and dendritic cells (DCs) based on their functions. Cells of MPCs lineage act as immune modulators by affecting effector cells, such as NK cells, T cells, and B cells. This study aimed to investigate the effects of Lacticaseibacillus paracasei strain Shirota (LcS) ingestion on peripheral MPCs, particularly on their expression of functional cell-surface molecules enhanced in healthy adults. Thus, twelve healthy office workers consumed a fermented milk drink containing 1.0 × 1011 cfu of LcS (LcS-FM) or a control unfermented milk drink (CM) once a day for 6 weeks. Peripheral blood mononuclear cells (PBMCs) were prepared from blood samples, and immune cells and functional cell-surface molecules were analyzed. We observed remarkable differences in the expression of HLAABC, MICA, CD40, and GPR43 in plasmacytoid DCs (pDCs) between the LcS-FM and CM groups, whereas no difference was found in CD86 or HLADR expression. The LcS-FM group exhibited higher CD40 expression in both conventional DCs (cDCs) and Mos, especially in type 2 conventional DCs (cDC2s) and classical monocytes (cMos); higher percentages of cMos, intermediate monocytes (iMos), and nonclassical monocytes; and higher numbers of cMos and iMos in PBMCs than the CM group. LcS ingestion increased the expression of HLAABC, MICA, CD40, and GPR43 in pDCs and CD40 in cDCs and Mos, particularly cDC2s and cMos. These results suggest that LcS modulates the function of MPCs that may lead to the regulation of immune effector functions in healthy adults.

著者

Tsuyoshi Isojima Noriko Kato Yoshiya Ito Susumu Kanzaki Mitsunori Murata

出版者

The Japanese Society for Pediatric Endocrinology

雑誌

Clinical Pediatric Endocrinology (ISSN:09185739)

巻号頁・発行日

vol.25, no.2, pp.71-76, 2016 (Released:2016-04-28)

参考文献数

8

被引用文献数

45 98

著者

加藤 典子 Noriko KATO 東京工芸大学工学部基礎教育研究センター非常勤

出版者

東京工芸大学工学部

雑誌

東京工芸大学工学部紀要 (ISSN:03876055)

巻号頁・発行日

vol.27, no.2, pp.90-99, 2004

著者

Toshiro Tango Toshiharu Fujita Takeo Tanihata Masumi Minowa Yuriko Doi Noriko Kato Shoichi Kunikane Iwao Uchiyama Masaru Tanaka Tetsunojo Uehata

出版者

日本疫学会

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.14, no.3, pp.83-93, 2004 (Released:2005-03-18)

参考文献数

33

被引用文献数

14 34

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BACKGROUND: Great public concern about health effects of dioxins emitted from municipal solid waste incinerators has increased in Japan. This paper investigates the association of adverse reproductive outcomes with maternal residential proximity to municipal solid waste incinerators.METHODS: The association of adverse reproductive outcomes with mothers living within 10 km from 63 municipal solid waste incinerators with high dioxin emission levels (above 80 ng international toxic equivalents TEQ/m3) in Japan was examined. The numbers of observed cases were compared with the expected numbers calculated from national rates adjusted regionally. Observed/expected ratios were tested for decline in risk or peak-decline in risk with distance up to 10 km.RESULTS: In the study area within 10 km from the 63 municipal solid waste incinerators in 1997-1998, 225, 215 live births, 3, 387 fetal deaths, and 835 infant deaths were confirmed. None of the reproductive outcomes studied here showed statistically significant excess within 2 km from the incinerators. However, a statistically significant peak-decline in risk with distance from the incinerators up to 10 km was found for infant deaths (p=0.023) and infant deaths with all congenital malformations combined (p=0.047), where a “peak” is detected around 1-2 km.CONCLUSION: Our study shows a peak-decline in risk with distance from the municipal solid waste incinerators for infant of deaths and infant deaths with all congenital malformations combined. However, due to the lack of detailed exposure information to dioxins around the incinerators, the observed trend in risk should be interpreted cautiously and there is a need for further investigation to accumulate good evidence regarding the reproductive health effects of waste incinerator exposure.