著者
Kasahara S. Watashige T. Hanaguri T. Kohsaka Y. Yamashita T. Shimoyama Y. Mizukami Y. Endo R. Ikeda H. Aoyama K. Terashima T. Uji S. Wolf T. von Lohneysen H. Shibauchi T. Matsuda Y.
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences (ISSN:00278424)
巻号頁・発行日
vol.111, no.46, pp.16309-16313, 2014-11
被引用文献数
146

「ボース・アインシュタイン凝縮に最も近い超伝導状態」を発見. 京都大学プレスリリース. 2014-11-05.
著者
Kasada M. Yamamichi M. Yoshida T.
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences (ISSN:00278424)
巻号頁・発行日
vol.111, no.45, pp.16035-16040, 2014-11-11
被引用文献数
17

遺伝的多様性の新しい影響を発見 -わずかな性質の違いが生態系を変化させる可能性-. 京都大学プレスリリース. 2014-10-23.
著者
Ma Guangyong Yasunaga Jun-Ichirou Akari Hirofumi Matsuoka Masao
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.112, no.7, pp.2216-2221, 2015-02-02
被引用文献数
10

ヒトT細胞白血病ウイルス1型の感染特異性の解明に成功 -HTLV-1感染症の病態解明に期待-. 京都大学プレスリリース. 2015-02-05.
著者
Hashimoto Kenichiro Mizukami Yuta Katsumata Ryo Shishido Hiroaki Yamashita Minoru Ikeda Hiroaki Matsuda Yuji Schlueter John A. Fletcher Jonathan D. Carrington Antony Gnida Daniel Kaczorowski Dariusz Shibauchi Takasada
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
2013-02-12
被引用文献数
17

絶対零度の量子ゆらぎにより重くなる超伝導電子 -電子が特定の方向で重くなる異常な現象を発見-. 京都大学プレスリリース. 2013-02-12.
著者
Sakata-Yanagimoto Mamiko Nakagami-Yamaguchi Etsuko Saito Toshiki Kumano Keiki Yasutomo Koji Ogawa Seishi Kurokawa Mineo Chiba Shigeru
出版者
The National Academy of Sciences of the USA
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.105, no.22, pp.7839-7844, 2008-06
被引用文献数
32 33

Mast cells are thought to participate in a wide variety of pathophysiological conditions. Mechanisms of regulation, however, of mast cell production and maturation are still to be elucidated. Mast cell developmental process is likely to be profoundly affected by cell-autonomous transcriptional regulators such as the GATA family and CCAAT/enhancer binding protein (C/EBP) family members. Extracellular regulators such as stem cell factor and IL-3 have essential roles in basal and inducible mast cell generation, respectively. The relationship, however, between the extracellular signaling and cellular transcriptional control is unclear, and the trigger of the mast cell development remains elusive. Notch signaling plays a fundamental role in the lymphopoietic compartment, but its role in myeloid differentiation is less clear. Here, we demonstrate that Notch signaling connects environmental cues and transcriptional control for mast cell fate decision. Delta1, an established Notch ligand, instructs bone marrow common myeloid progenitors and granulocyte-macrophage progenitors toward mast cell lineage at the expense of other granulocyte-macrophage lineages, depending on the function of the Notch2 gene. Notch2 signaling results in the up-regulation of Hes-1 and GATA3, whereas simultaneous overexpression of these transcription factors remarkably biases the progenitor fate toward the mast cell-containing colony-forming cells. C/EBPα mRNA was down-regulated in myeloid progenitors as a consequence of Hes-1 overexpression, in agreement with the recent proposal that the down-regulation of C/EBPα is necessary for mast cell fate determination. Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3.
著者
Yashiro Toshihisa Matsuura Kenji
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.111, no.48, pp.17212-17217, 2014-11-17
被引用文献数
10

昆虫が有性生殖と単為生殖を切り替える仕組みを解明 -シロアリ女王、卵の孔を閉じて精子通さず-. 京都大学プレスリリース. 2014-11-18.
著者
Kuroi Kunisato Okajima Koji Ikeuchi Masahiko Tokutomi Satoru Terazima Masahide
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.111, no.41, pp.14764-14769, 2014-09-29
被引用文献数
11 5

生体タンパク質反応の鍵となる「揺らぎ」検出に成功 -新規薬剤探索の新指針に期待-. 京都大学プレスリリース. 2014-10-03.
著者
Saito Keisuke Rutherford A William Ishikita Hiroshi
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
2013-04-18
被引用文献数
32

光合成酸素発生反応で利用される蛋白質内のプロトン移動経路を発見 : 人工光合成系の設計やバイオエネルギーの生産性向上に指針. 京都大学プレスリリース. 2013-04-16.
著者
Koyabu Daisuke Maier Wolfgang Sánchez-Villagra Marcelo R.
出版者
National Academy of Sciences
雑誌
Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日
vol.109, no.35, pp.14075-14080, 2012-08-28
被引用文献数
37

ヒトをはじめとする哺乳類の頭蓋骨の進化的起源を解明. 京都大学プレスリリース. 2012-08-14.