文献一覧: Proceedings of the National Academy of Sciences of the United States of America (雑誌)

4 0 0 0 OA Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells.

著者: Koyanagi-Aoi Michiyo Ohnuki Mari Takahashi Kazutoshi Okita Keisuke Noma Hisashi Sawamura Yuka Teramoto Ito Narita Megumi Sato Yoshiko Ichisaka Tomoko Amano Naoki Watanabe Akira Morizane Asuka Yamada Yasuhiro Sato Tosiya Takahashi Jun Yamanaka Shinya
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日: 2013-11-20
被引用文献数: 189

大規模解析により品質の悪い多能性幹細胞の見分け方を開発. 京都大学プレスリリース. 2013-11-19.

2014-01-02 07:26:04
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4 0 0 0 OA Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

著者: Hikichi Takafusa Matoba Ryo Ikeda Takashi Watanabe Akira Yamamoto Takuya Yoshitake Satoko Tamura-Nakano Miwa Kimura Takayuki Kamon Masayoshi Shimura Mari Kawakami Koichi Okuda Akihiko Okochi Hitoshi Inoue Takafumi Suzuki Atsushi Masui Shinji
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)
巻号頁・発行日: 2013-04-02
被引用文献数: 31

初期化を阻害する転写因子が分化を促進する. 京都大学プレスリリース. 2013-04-02.

2013-04-25 21:30:53
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3 0 0 0 OA RPT2/NCH1 subfamily of NPH3-like proteins is essential for the chloroplast accumulation response in land plants

著者: Suetsugu Noriyuki Takemiya Atsushi Kong Sam-Geun Higa Takeshi Komatsu Aino Shimazaki Ken-ichiro Kohchi Takayuki Wada Masamitsu
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)
巻号頁・発行日: vol.113, no.37, 2016-08-30
被引用文献数: 33

葉緑体が光に集まる反応を制御する新たな因子の発見. 京都大学プレスリリース. 2016-08-30.

2016-08-31 18:20:22
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3 0 0 0 OA TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.

著者: Ma Guangyong Yasunaga Jun-Ichirou Akari Hirofumi Matsuoka Masao
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日: vol.112, no.7, pp.2216-2221, 2015-02-02
被引用文献数: 24

ヒトT細胞白血病ウイルス1型の感染特異性の解明に成功 -HTLV-1感染症の病態解明に期待-. 京都大学プレスリリース. 2015-02-05.

2015-02-06 09:15:44
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2 0 0 0 OA Nonoverlapping roles of PD-1 and FoxP3 in maintaining immune tolerance in a novel autoimmune pancreatitis mouse model.

著者: Zhang Baihao Chikuma Shunsuke Hori Shohei Fagarasan Sidonia Honjo Tasuku
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)
巻号頁・発行日: vol.113, no.30, pp.8490-8495, 2016-07-07
被引用文献数: 131

免疫のブレーキPD-1は、制御性T細胞との役割分担によって自己免疫性膵炎を抑制する. 京都大学プレスリリース. 2016-07-20.

2016-07-21 14:12:10
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2 0 0 0 OA Protease homolog BepA (YfgC) promotes assembly and degradation of β-barrel membrane proteins in Escherichia coli

著者: Narita Shin-Ichiro Masui Chigusa Suzuki Takehiro Dohmae Naoshi Akiyama Yoshinori
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)
巻号頁・発行日: 2013-09-03
被引用文献数: 60

膜タンパク質の組立と分解に関わる新規プロテアーゼを発見. 京都大学プレスリリース. 2013-09-03.

2013-09-09 15:18:52
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2 0 0 0 OA Anomalous superfluid density in quantum critical superconductors

著者: Hashimoto Kenichiro Mizukami Yuta Katsumata Ryo Shishido Hiroaki Yamashita Minoru Ikeda Hiroaki Matsuda Yuji Schlueter John A. Fletcher Jonathan D. Carrington Antony Gnida Daniel Kaczorowski Dariusz Shibauchi Takasada
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日: 2013-02-12
被引用文献数: 26

絶対零度の量子ゆらぎにより重くなる超伝導電子 -電子が特定の方向で重くなる異常な現象を発見-. 京都大学プレスリリース. 2013-02-12.

2013-02-20 01:57:15
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2 0 0 0 OA Chimpanzees' flexible targeted helping based on an understanding of conspecifics' goals.

著者: Yamamoto Shinya Humle Tatyana Tanaka Masayuki
出版者: National Academy of Sciences
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:10916490)
巻号頁・発行日: 2012-02-06
被引用文献数: 151

相手の状況に合わせたチンパンジーの手助け行動. 京都大学プレスリリース. 2012-02-07.

2013-01-03 20:24:26
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2 0 0 0 OA Coordinated regulation of transcription factors through Notch2 is an important mediator of mast cell fate

著者: Sakata-Yanagimoto Mamiko Nakagami-Yamaguchi Etsuko Saito Toshiki Kumano Keiki Yasutomo Koji Ogawa Seishi Kurokawa Mineo Chiba Shigeru
出版者: The National Academy of Sciences of the USA
雑誌: Proceedings of the National Academy of Sciences of the United States of America (ISSN:00278424)
巻号頁・発行日: vol.105, no.22, pp.7839-7844, 2008-06
被引用文献数: 50 33

Mast cells are thought to participate in a wide variety of pathophysiological conditions. Mechanisms of regulation, however, of mast cell production and maturation are still to be elucidated. Mast cell developmental process is likely to be profoundly affected by cell-autonomous transcriptional regulators such as the GATA family and CCAAT/enhancer binding protein (C/EBP) family members. Extracellular regulators such as stem cell factor and IL-3 have essential roles in basal and inducible mast cell generation, respectively. The relationship, however, between the extracellular signaling and cellular transcriptional control is unclear, and the trigger of the mast cell development remains elusive. Notch signaling plays a fundamental role in the lymphopoietic compartment, but its role in myeloid differentiation is less clear. Here, we demonstrate that Notch signaling connects environmental cues and transcriptional control for mast cell fate decision. Delta1, an established Notch ligand, instructs bone marrow common myeloid progenitors and granulocyte-macrophage progenitors toward mast cell lineage at the expense of other granulocyte-macrophage lineages, depending on the function of the Notch2 gene. Notch2 signaling results in the up-regulation of Hes-1 and GATA3, whereas simultaneous overexpression of these transcription factors remarkably biases the progenitor fate toward the mast cell-containing colony-forming cells. C/EBPα mRNA was down-regulated in myeloid progenitors as a consequence of Hes-1 overexpression, in agreement with the recent proposal that the down-regulation of C/EBPα is necessary for mast cell fate determination. Taken together, signaling through Notch2 determines the fate of myeloid progenitors toward mast cell-producing progenitors, via coordinately up-regulating Hes-1 and GATA3.