著者

Ke-Hsuan WANG Genta WATANABE Hayato IKEUCHI Siyang CUI I-Ping LIU Kanta YAMADA Masaaki YOSHIDA Takeshi KAWAI

出版者

The Japan Society for Analytical Chemistry

雑誌

Analytical Sciences (ISSN:09106340)

巻号頁・発行日

vol.36, no.1, pp.27-34, 2020-01-10 (Released:2020-01-10)

参考文献数

43

被引用文献数

6

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A key requirement in developing oxygen evolution reaction (OER) electrocatalysts is increasing their surface area. Herein, we report the design of a hierarchical micro/nanostructured catalyst. Based on polystyrene colloidal template electrodeposition, an ordered microcup array surrounded by nanoflakes was fabricated. The effect of the deposition time on the formation of the catalyst and the corresponding OER performance of the catalyst were investigated using scanning electron microscopy, in situ X-ray absorption fine structure (XAFS) spectroscopy, and electrochemical analysis. The in situ XAFS measurements indicate that the structure of the hierarchical structured catalyst is similar to that of γ-FeOOH. The electrochemical analysis indicates that the hierarchical catalyst has a large surface area and a low charge transfer resistance, which lead to its excellent catalytic performance for the OER. Our study provides new insights in designing high-performance OER catalysts. Moreover, the synthesized hierarchical micro/nanostructured catalyst could be used as a platform for further studies on low-cost iron-based electrocatalysts.

著者

Jing Xue Xiaorong Li Ping Liu Ke Li Liping Sha Xiaoli Yang Lili Zhu Zhen Wang Youping Dong Li Zhang Hong Lei Xiaoxia Zhang Xiaoying Dong Hao Wang

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ18-0567, (Released:2019-07-03)

被引用文献数

71

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Polycystic ovary syndrome (PCOS) represents an endocrine disorder, which is closely related with gut microbiota. Inulin, a kind of probiotics, has been proven to alleviate gut microbiota dysbiosis. Metformin, a biguanide agent, shows beneficial effects on chronic metabolic diseases. Our objective was to assess the effects and associated mechanisms of inulin and metforin on attenuation of PCOS in mice. Mice were divided into 4 groups: control group (CON), model group (MOD), inulin group (INU), metformin group (MET). The last three groups were fed 6 mg of dehydroepiandrosterone (DHEA) per 100 g body weight and 60% high-fat diet to generate mice model. After 21 days of intervention, mice were euthanized and associated indications were investigated. Body weight (BW) and testosterone (T) levels were significantly decreased, but estradiol (E2) levels were increased in INU or MET group, respectively. Ovary HE staining demonstrated that inulin or metformin ameliorated PCOS morphology. Inflammatory indicators from plasma and ovary including TNF-α, IL-6, and IL-17A were decreased in INU or MET group. Moreover, IL-10 in ovary of INU or MET group was increased. Sequencing and analysis of gut microbiota showed that compared to MOD group, Bifidobacterium was increased, but Proteobacteria, Helicobacter and Parasutterella were decreased in INU group. Helicobacter was decreased in MET group. Correlation analysis showed that gut microbiota was correlated with inflammatory factors. Our results revealed that inulin and metformin alleviated PCOS via anti-inflammation and modulating gut microbiota, which may contribute to potential clinical therapy for the disease.