- 著者
- Ryuichi SAITO Naoki SATO Yoichi OKINO Dian-Sheng WANG Genichiro SEO
- 出版者
- BMFH Press
- 雑誌
- Bioscience of Microbiota, Food and Health (ISSN:21863342)
- 巻号頁・発行日
- vol.42, no.2, pp.124-130, 2023 (Released:2023-04-01)
- 参考文献数
- 33
- 被引用文献数
- 2
Clostridium butyricum TO-A, Enterococcus faecium T-110, and Bacillus subtilis TO-A are sold as oral probiotic preparations and reportedly exhibit many beneficial effects on the health of hosts, including humans and livestock. In this study, we compared the ability of these clinically applied probiotic bacteria with Escherichia coli OP50 in extending the lifespan of Caenorhabditis elegans. To compare the C. elegans lifespan-extending effects of the three bacteria, experiments were performed using a nematode growth medium containing a small amount of trypticase soy agar. The maximum lifespans of worms fed C. butyricum TO-A, E. faecium T-110, or B. subtilis TO-A increased by 11, 12, and 26%, respectively, compared with worms fed E. coli OP50. In addition, we conducted a metabolomic analysis of methanol extracts of B. subtilis TO-A cells, which exhibited the strongest lifespan-extending effect on C. elegans among the probiotic bacteria tested in this study. As a result, 59 candidate substances involved in extending the lifespan of C. elegans were identified in B. subtilis TO-A cells.
- 著者
- Katsuma Ikeuchi Yuki Yasuda Ryuichi Saito Seiji Nishida Yasushi Orita Chiaki Sakamoto
- 出版者
- Japanese Association of Occupational Therapists
- 雑誌
- Asian Journal of Occupational Therapy (ISSN:13473476)
- 巻号頁・発行日
- vol.18, no.1, pp.17-23, 2022 (Released:2022-01-28)
- 参考文献数
- 26
Introduction: Peer support programs are mainly studied by hospitals and medical professionals, and further research is needed on their impact on quality of life (QOL). The purpose of this study was to investigate the type of community-based peer support program that is effective for improving the QOL of cancer survivors. Method: A systematic review was performed using the following procedures: (1) randomized controlled trials aimed at improving QOL were searched from PubMed and Igaku Chuo Zasshi, (2) papers that met the inclusion criteria were selected, and (3) the papers were assessed for quality by using the revised Cochrane risk-of-bias tool for randomized trials.Results: Results showed that four studies met the eligibility criteria, and three of them showed statistically significant improvements in QOL. The peers instructed in programs were breast cancer survivors who had been diagnosed one to three years earlier. Furthermore, peers received special training for approximately eight hours per session for a total of two to seven days before providing support to the participants.Conclusion: Few programs have been fully applied in Japan. In terms of program effectiveness and risk of bias, programs that include obtaining support and managing activities that affect mood may be effective. Furthermore, the importance of taking enough time to help cancer survivors trust each other and provide support according to the patient's wishes and available community resources was demonstrated.