著者
Yasumi Kimura Hitomi Suga Satomi Kobayashi Satoshi Sasaki the Three-Generation Study of Women on Diets and Health Study Group
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20190010, (Released:2019-06-22)
参考文献数
48
被引用文献数
14

Background: Depression in elderly people is a major global concern around the world. Epidemiological evidence of the association of beverages with depressive symptoms has received research attention; however, epidemiological studies on the association of coffee and green tea with depressive symptoms for the elderly population are limited. The objective of this study is to cross-sectionally examine the association of depressive symptoms with the intake of coffee, green tea and caffeine and to verify the antidepressant effect of caffeine.Methods: The subjects were 1992 women aged 65–94 years. Intakes of coffee, green tea and caffeine as well as depressive symptoms were assessed with a validated brief dietary history questionnaire (BDHQ) and the Center for Epidemiologic Studies Depression Scale (CES-D), respectively. Multiple logistic regression analysis was used to calculate odds ratios (OR) and 95% confidence intervals (CI) for depressive symptoms with adjustments for potential confounders.Results: Coffee intake was associated with a lower prevalence of depressive symptoms, the ORs of which for the 4th vs. the 1st quartiles of intake was 0.64 (95% CI 0.46-0.88, P for trend = 0.01) in a fully adjusted model. Caffeine intake was marginally associated with depressive symptoms, but the association was not statistically significant (OR = 0.75; 95% CI 0.55–1.02, P for trend = 0.058).Conclusion: The result suggests that the inverse association on depressive symptoms might be expected not only caffeine intake but also some other substances in coffee or factors related to coffee intake. Because of its cross-sectional design, longitudinal studies are required to confirm the present finding.
著者
Ayumi Hashimoto Kentaro Murakami Satomi Kobayashi Hitomi Suga Satoshi Sasaki the Three-generation Study of Women on Diets and Health Study Group
出版者
Japan Epidemiological Association
雑誌
Journal of Epidemiology (ISSN:09175040)
巻号頁・発行日
pp.JE20200030, (Released:2020-05-16)
参考文献数
34
被引用文献数
4

Background: The disparity of overall diet quality by personal educational attainment has been a public issue. However, it remains unknown which food groups contribute to the disparity. This cross-sectional study assesses which food groups explain associations between education and overall diet quality in Japanese women.Methods: A total of 3788 middle-aged (mean: 47.7 years) and 2188 older women (mean: 74.4 years), who lived in 47 prefectures in Japan, provided data on their education (low, middle, and high) and dietary intakes from a diet history questionnaire. A diet quality score (possible score 0-70) was calculated based on seven food components. Mean diet quality scores with adjustment for lifestyle and neighborhood variables were estimated by education, and Dunnett’s multiple comparison was conducted. Additionally, mean scores of each food component were estimated by education and compared using the same manner.Results: After adjustment for lifestyle and neighborhood variables, mean diet quality score of high or middle education was higher than low education for both generations. Middle-aged women with high and middle education had higher scores of ‘milk’, ‘snacks, confection, and beverages’, ‘fruits’, and ‘vegetable dishes’ than those with low education. Older women with high and middle education had higher scores of ‘sodium from seasonings’ and ‘fruits’ than those with low education.Conclusions: This study suggests that positive associations between education and diet quality are explained by different food groups in middle-aged and older Japanese women, which are independent of lifestyle and neighborhood variables.
著者
Ryoko Katagiri Keiko Asakura Satomi Kobayashi Hitomi Suga Satoshi Sasaki
出版者
(公社)日本産業衛生学会
雑誌
Journal of Occupational Health (ISSN:13419145)
巻号頁・発行日
pp.14-0051-OA, (Released:2014-08-28)
被引用文献数
1 163

Objectives: Although workers with poor sleep quality are reported to have problems with work performance, few studies have assessed the association between dietary factors and sleep quality using validated indexes. Here, we examined this association using information acquired from validated questionnaires. Methods: A total of 3,129 female workers aged 34 to 65 years were analyzed. Dietary intake was assessed using a self-administered diet history questionnaire (DHQ), and subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). The relationship between the intake of several food groups and nutrients and sleep quality was examined using multivariable logistic regression models. The effect of eating habits on sleep quality was also examined. Results: Poor sleep quality was associated with low intake of vegetables (p for trend 0.002) and fish (p for trend 0.04) and high intake of confectionary (p for trend 0.004) and noodles (p for trend 0.03) after adjustment for potential confounding factors (age, body mass index, physical activity, depression score, employment status, alcohol intake and smoking status). Poor sleep quality was also significantly and positively associated with consumption of energy drinks and sugar-sweetened beverages, skipping breakfast, and eating irregularly. In addition, poor sleep quality was significantly associated with high carbohydrate intake (p for trend 0.03). Conclusion: A low intake of vegetables and fish, high intake of confectionary and noodles and unhealthy eating habits were independently associated with poor sleep quality. Poor sleep quality was also associated with high carbohydrate intake in free-living Japanese middle-aged female workers.
著者
Satoshi Kosukegawa Yuka Nakaya Satomi Kobayashi Kohei Kitano Sachie Matsumura Shohei Ogisawa Manabu Zama Mitsuru Motoyoshi Masayuki Kobayashi
出版者
Nihon University School of Dentistry
雑誌
Journal of Oral Science (ISSN:13434934)
巻号頁・発行日
pp.22-0438, (Released:2023-02-23)
参考文献数
24
被引用文献数
1

Purpose: Inhibitory synaptic currents from fast-spiking neurons (FSNs), a typical gamma-aminobutyric acid (GABA)ergic interneuron in the cerebral cortex, to pyramidal neurons are facilitated by insulin. FSNs frequently show electrical synapses to FSNs, however, the effect of insulin on these electrical synapses is unknown. The aim of this study was to evaluate effects of insulin on electrical synaptic potentials between FSNs.Methods: Electrical synaptic potentials via gap junctions between FSNs were recorded to examine how insulin modulates these potentials in the rat insular cortex (IC).Results: Bath application of insulin (10 nM), which increases the spike firing rate of pyramidal neurons and unitary inhibitory postsynaptic currents recorded from FSN to pyramidal neuron connections, slightly but significantly increased electrical synaptic currents. The mean ratio of electrical synapses, the coupling coefficient that is obtained by postsynaptic voltage responses divided by presynaptic voltage amplitude, was 8.3 ± 1.1% in control and 9.2 ± 1.1% (n = 14) during 10 nM insulin application. Input resistance and voltage responses to large hyperpolarizing currents (−140 pA) were not changed by insulin.Conclusion: These results suggest that insulin facilitates spike synchronization by increasing electrical synaptic currents via gap junctions of GABAergic FSNs in the IC.
著者
Shutaro Kobayashi Kazunori O’Hashi Keisuke Kaneko Satomi Kobayashi Shouhei Ogisawa Morio Tonogi Satoshi Fujita Masayuki Kobayashi
出版者
Nihon University School of Dentistry
雑誌
Journal of Oral Science (ISSN:13434934)
巻号頁・発行日
pp.21-0528, (Released:2022-02-16)
参考文献数
28
被引用文献数
1

Purpose: Unless the phenotype of the transgenic mice is distinguishable, genotyping in each mouse is required prior to experiments. This study aimed to establish a new identification method for the phenotype in Thy1-GCaMP6s transgenic mice to reduce the cost and time.Methods: Tail biopsies (2 mm) were performed under general anesthesia with isoflurane in 3 to 4-week-old mice. Then, the resected tail was cut again with a sharp razor, and the cross-sections were observed with two-photon microscopy (excitation wavelength = 940 nm). The emitted light was split into green and red light by a dichroic mirror (570 nm) with bandpass filters (495-540 nm for green, 575-645 nm for red).Results: Two types of expressed fluorescent pattern were found in the tail tissue: the presence of green fluorescent structures (type 1) and the absence of the structures (type 2). Cortical imaging confirmed that type 1 expressed the cortical GCaMP6s, while type 2 did not.Conclusion: These results suggest that observation of the cross-sectioned tail in Thy1-GCaMP6s mice enabled to identify the phenotype within approximately 10 min/mouse, which reduces the cost and time for genotyping.