著者

Kyozo Sasaki Mitsuru Motoyoshi Eri Horinuki Yoshinori Arai Noriyoshi Shimizu

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.58, no.3, pp.415-422, 2016 (Released:2016-09-25)

参考文献数

31

被引用文献数

4

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This study examined the effects of a bite-jumping appliance combined with low-intensity pulsed ultrasound (LIPUS) stimulation on the mandibular condyle of growing rats using micro CT (mCT) and histological examinations. Twelve Wistar rats were divided into three groups of four individuals each: Group 1 was an untreated control group, Group 2 received bite-jumping appliances, and Group 3 received bite-jumping appliances and LIPUS stimulation (15 min/day, 2 weeks) to the temporomandibular region. We measured the length and three-dimensional bone volume of each rat’s mandibular condyle using mCT. The condylar cartilage was observed after the rats had been sacrificed. There was no significant difference in condylar sagittal width among the groups. The bite-jumping appliance combined with LIPUS stimulation increased the condylar major axis, mandibular sagittal length and condylar bone volume to a greater degree than use of the bite-jumping appliance alone. Histological examination demonstrated hypertrophy of the condylar cartilage layers, the fibrous layer and hypertrophic cell layer of the rats treated with bite-jumping appliances combined with LIPUS stimulation in comparison to rats treated with bite-jumping appliances alone. (J Oral Sci 58, 415-422, 2016)

著者

Mari Namura Mitsuru Motoyoshi Yasuhiro Namura Noriyoshi Shimizu

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.50, no.1, pp.45-51, 2008 (Released:2008-04-11)

参考文献数

28

被引用文献数

4 10

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Although orthodontic treatment improves dentoalveolar problems, the facial profile seldom changes because the perioral muscles do not easily adapt to the new morphological circumstances. We employed proprioceptive neuromuscular facilitation (PNF), which is training with added resisted movement to motions such as lifting the upper lip, lowering the lower lip, and sticking out the tongue, to adapt the perioral muscles to the new morphological circumstances. The subjects were 40 adults with an average age of 29.6 years. A series of PNF exercises was performed three times per day for 1 month. Lateral facial photographs were taken using a digital camera before training (T0), after training (T1), and 1 month after the end of training (T2). The nasolabial (NL), mentolabial (ML), and mentocervical (MC) angles were measured, and linear measurements were taken to verify the change of each measurement point. In the test group, the NL and ML angles significantly increased (P < 0.05), and the MC angle significantly decreased after the PNF exercise. From T1 to T2, the NL and ML angles decreased significantly, while the MC angle increased significantly. No significant differences were observed in these angles when the values measured at T0 and T2 were compared. Although the training appeared to be effective for sharpening the mouth and submandibular region, continued training is necessary to avoid relapse. (J. Oral Sci. 50, 45-51, 2008)

著者

Satoshi Kosukegawa Yuka Nakaya Satomi Kobayashi Kohei Kitano Sachie Matsumura Shohei Ogisawa Manabu Zama Mitsuru Motoyoshi Masayuki Kobayashi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.22-0438, (Released:2023-02-23)

参考文献数

24

被引用文献数

1

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Purpose: Inhibitory synaptic currents from fast-spiking neurons (FSNs), a typical gamma-aminobutyric acid (GABA)ergic interneuron in the cerebral cortex, to pyramidal neurons are facilitated by insulin. FSNs frequently show electrical synapses to FSNs, however, the effect of insulin on these electrical synapses is unknown. The aim of this study was to evaluate effects of insulin on electrical synaptic potentials between FSNs.Methods: Electrical synaptic potentials via gap junctions between FSNs were recorded to examine how insulin modulates these potentials in the rat insular cortex (IC).Results: Bath application of insulin (10 nM), which increases the spike firing rate of pyramidal neurons and unitary inhibitory postsynaptic currents recorded from FSN to pyramidal neuron connections, slightly but significantly increased electrical synaptic currents. The mean ratio of electrical synapses, the coupling coefficient that is obtained by postsynaptic voltage responses divided by presynaptic voltage amplitude, was 8.3 ± 1.1% in control and 9.2 ± 1.1% (n = 14) during 10 nM insulin application. Input resistance and voltage responses to large hyperpolarizing currents (−140 pA) were not changed by insulin.Conclusion: These results suggest that insulin facilitates spike synchronization by increasing electrical synaptic currents via gap junctions of GABAergic FSNs in the IC.

著者

Yasuki Uchida Yasuhiro Namura Mizuki Inaba Ayaka Osada Tasku Charleston-Coad Yoshiki Nakamura Mitsuru Motoyoshi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.63, no.3, pp.270-274, 2021 (Released:2021-06-29)

参考文献数

26

被引用文献数

5

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Purpose: The aim of this study was to investigate the stability of orthodontic anchor screws (OASs) in the mid-palatal area according to pre-drilling diameter.Methods: The success rate of 161 OASs (83 patients, φ2.0 mm, 6.0 mm in length) placed in a corresponding area to the mesial and distal borders of the first molar (mesial zone and distal zone) was assessed according to placement location and pre-drilling diameter (1.2 and 1.5 mm). Placement torque values from 73 OASs with a pre-drilling diameter of 1.2 mm were compared between success and failure groups.Results: The success rates of OASs pre-drilled with φ1.2 and 1.5 mm were 94.5% and 83.0%, respectively (P < 0.05); corresponding rates in the mesial zone were 100.0% and 77.3% (P < 0.005), and those in the distal zone were 89.2% and 88.6%, respectively. Placement torques of OASs predrilled with φ1.2 mm in the success and failure groups were 25.9 and 19.2 N·cm, respectively (P < 0.05).Conclusion: A smaller pre-drilling diameter was associated with a higher success rate of OASs in the mid-palatal area, especially in the mesial zone. When pre-drilling diameter of 1.2 mm was used for φ2.0 mm OAS, greater placement torque was indicative of greater OAS stability.

著者

Atsuko Hotta Yasuki Uchida Yasuhiro Namura Mizuki Inaba Mitsuru Motoyoshi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.3, pp.318-321, 2020 (Released:2020-06-23)

参考文献数

30

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This study used finite element (FE) analysis to investigate the stability of miniscrews (screws) placed at the median palate. FE models with variable suture maturity and screw-suture distances were used to examine the relationship with screw stability. Four groups were classified by extent of maturation of the midpalatal suture (0%, 60%, 75%, and 100%). The placement position was set at the center of the suture (0.0 mm), or 0.5, 1.0, and 1.5 mm to the side of the suture, and von Mises stress values in bone and screw displacement were compared among models. The stress value for the unsutured model, in which the screw was placed at the center of the suture, was greater than 30 MPa. Stress values for models in which screws were placed to the side (0.5-1.5 mm) were less than 28 MPa. Maximum screw displacement was greater in the 0.0-mm incomplete suture model than at other placement positions. Because bone conditions vary among patients, placement position and suture maturation should be examined on cone beam-computed tomography images, to ensure screw stability.

著者

Eri Sata Leo Takada Ryo Kaetsu Mai Fukasawa Mariko Ohtsu Mitsuru Motoyoshi Masatake Asano

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.19-0477, (Released:2020-06-04)

参考文献数

14

被引用文献数

3

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Interleukin-1α (IL-1α) is produced inside cells in its precursor form (pIL-1α). Enzymatic cleavage yields mature (mIL-1α) and the propiece of IL-1α (ppIL-1α), which are thought to be localized in the nucleus, because of the presence of nuclear localizing signals. Studies of ppIL-1α function have been hampered by the lack of a ppIL-1α-specific antibody (Ab). In the present study, the authors generated anti-ppIL-1α Ab by using recombinant histidine-tagged ppIL-1α (His-ppIL-1α) as an immunogen. Rabbits were immunized with His-ppIL-1α, and affinity-purified Ab was obtained. Ab reactivity and specificity were examined by Western blotting. The antibody successfully recognized transfectant-derived green fluorescence protein (GFP)-tagged ppIL-1α but not GFP. A sandwich enzyme-linked immunosorbent assay (ELISA) system established by biotinylating the anti-ppIL-1α Ab successfully detected GFP-ppIL-1α. The Ab and ELISA system allows functional analysis of ppIL-1α and improves understanding of ppIL-1α.

著者

Yasuhiro Namura Toshiki Takamizawa Yasuki Uchida Mizuki Inaba Daichi Noma Tomoko Takemoto Masashi Miyazaki Mitsuru Motoyoshi

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.62, no.1, pp.48-51, 2020 (Released:2020-01-29)

参考文献数

20

被引用文献数

8

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Although there have been improvements in bracket systems precoated with adhesive, removal of adhesive remnants continues to be problematic. This study compared the hardness and maintainability of precoated adhesive with other commercial adhesives. Knoop hardness values were measured after light- or chemical-induced initial curing, immersion in distilled water at 37°C for 24 h and 1,000 and 10,000 thermal cycles after 24 h. Additionally, the forces required to move brackets by 0.5 mm were measured during bracket positioning, and brackets bonded to bovine enamel were examined by field-emission scanning electron microscopy. The Knoop hardness values of the precoated adhesives were lower than those of commercial resin composite adhesives, and hardness was dependent on the amount of filler in the resin matrix. The ability to maintain the device position may depend on the resin matrix composition. Precoated adhesives with less filler and more matrix material are light curable, and remnant resin may be easily removed.

著者

Yasuhiro NAMURA Yasuki UCHIDA Ryoichi SATO Noriyoshi SHIMIZU Mitsuru MOTOYOSHI Yusuke TSUTSUMI Takao HANAWA Takayuki YONEYAMA

出版者

The Japanese Society for Dental Materials and Devices

雑誌

Dental Materials Journal (ISSN:02874547)

巻号頁・発行日

pp.2019-023, (Released:2019-12-19)

参考文献数

21

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Chemical transitions after atmospheric pressure plasma irradiation were investigated by evaluating intermolecular attractions and atomic and molecular reactions. Gold, titanium and stainless-steel alloy samples were ground with #800 grit SiC waterproof paper and nitrogen gas atmospheric plasma irradiation was conducted. The surface free energies of the treated alloys were calculated and compared statistically. X-ray photoelectron spectroscopy analysis was performed.The surface free energies of all metal surfaces treated by plasma irradiation were 1.5-times higher than those of the untreated metals. The energy of the hydrogen bonding component increased, and all alloy surfaces were coated with metal oxide after only a short period of plasma irradiation. The surfaces oxidized by plasma exhibited a high active energy, mainly due to an increase in the hydrogen bonding component. Reactions with oxygen in the air were promoted on the clean surfaces with exposed reactive elements.

著者

Michiko Ichinohe Mitsuru Motoyoshi Mizuki Inaba Yasuki Uchida Mari Kaneko Reiko Matsuike Noriyoshi Shimizu

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

pp.17-0377, (Released:2018-10-26)

参考文献数

35

被引用文献数

19

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This study investigated the stability of mini-screws placed in the median palate. The study included 25 patients (7 males, 18 females; mean age, 23.4 ± 5.6 years; age range, 15.0-34.5 years) who had mini-screws placed during orthodontic treatment at Nihon University School of Dentistry Dental Hospital. Mini-screws (diameter, 2.0 mm; length, 9.0 mm) were placed in the median palatal region; the first screw was inserted mesiodistally at the distal contact of the maxillary first molar, and the second screw was placed 6-9 mm mesial to the first screw. Immediately after placement, the placement sites were carefully examined with cone-beam computed tomography and a Periotest device. Screw stability was not related to perforation of the nasal cavity, patient age, or patient sex. The success rate was significantly higher in patients with screw-suture distances of 1.5-2.7 mm than in those with distances of 0-1.4 mm. Moreover, mini-screws could be stabilized when palatal cortical bone thickness was ≥1.5 mm. The success rate was significantly higher in the group with insertion depths of ≥4.5 mm. These results indicate that primary stability of mini-screws requires sufficient cortical bone thickness, insertion depth, and screw-suture distance.

著者

Wakako Miyama Yasuki Uchida Mitsuru Motoyoshi Keiko Motozawa Moeko Kato Noriyoshi Shimizu

出版者

Nihon University School of Dentistry

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.60, no.1, pp.147-153, 2018 (Released:2018-03-24)

参考文献数

28

被引用文献数

2

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This study examined the relationship of vertical and horizontal changes in the alveolar bone crest with upper incisor movement after orthodontic treatment. Tooth movement was measured on lateral cephalograms. Vertical and horizontal changes in the median alveolar crest and distance from the cementoenamel junction and anterior nasal spine to the alveolar crest were measured with cone-beam computed tomography. The incisal edge moved distally, and the cervical point intruded significantly and moved distally. The median alveolar crest decreased by 3.80 ± 2.05 mm. The distance from the labial cementoenamel increased significantly, by 0.35 ± 0.38 mm. The vertical distance from the anterior nasal spine decreased significantly, and the alveolar crest moved distally. Vertical tooth movement was positively associated with change in the distance from the labial cementoenamel junction and inversely associated with vertical change in the distance from the anterior nasal spine on the labial and palatal sides. Lingual tooth movement was positively and negatively correlated with horizontal changes in the labial and palatal alveolar crest and vertical change in the palatal alveolar crest. The lingual movement of incisors was related to labial bone resorption. Greater lingual and extrusive movement of incisors led to a greater decrease in the alveolar bone crest.

著者

Tomoyasu Kiyokawa Mitsuru Motoyoshi Mizuki Inaba Remi Sano Akari Saiki Go Torigoe Masatake Asano Noriyoshi Shimizu

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.59, no.3, pp.447-451, 2017 (Released:2017-09-14)

参考文献数

22

被引用文献数

2

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The purpose of this experiment was to investigate whether low-intensity pulsed ultrasound (LIPUS) irradiation can inhibit dentoalveolar ankylosis in transplanted rat teeth. LIPUS irradiation (the pulsed ultrasound signal had a frequency of 3.0 MHz, a spatial average intensity of 30 mW/cm2, and a pulse ratio of 1:4) was performed on the face over the re-planted teeth of rats for 4 weeks. After the rats were euthanized, we measured mobility (Periotest value [PTV]) of the transplanted and control teeth using a Periotest. Finally, we performed histological evaluation to detect ankylosis. PTVs tended to be significantly lower for re-planted teeth than for control teeth. Histological evaluation revealed that the roots of all re-planted teeth were coalescent with alveolar bone. Furthermore, no ankylosis was observed in three-fifths of the re-planted teeth following LIPUS irradiation. These results indicate the potential efficacy of LIPUS to inhibit dentoalveolar ankylosis.

著者

Yasuki Uchida Mitsuru Motoyoshi Yasuhiro Namura Noriyoshi Shimizu

出版者

日本大学歯学部

雑誌

Journal of Oral Science (ISSN:13434934)

巻号頁・発行日

vol.59, no.2, pp.257-262, 2017 (Released:2017-06-22)

参考文献数

29

被引用文献数

5

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This study investigated guidelines for placement of monocortical screws in the mandible, particularly the mandibular canal. In this study of 35 patients, we used cone-beam computed tomography to determine the distance from the alveolar crest to the superior border of the mandibular canal (DMC) and the shortest distance from the buccal and lingual cortex to the mandibular canal (attaining distance) in the areas between premolars (premolar area), between the second premolar and first molar (middle area), and between the first and second molars (molar area). The DMC values for these areas were 16.55, 18.94, and 16.58 mm, respectively, and were similar in adults and adolescents. When the attaining distance was 8 mm, the heights on the buccal and lingual sides of the areas were 9 and 16.6 mm, 13.7 and 14.7 mm, and 15.3 and 12 mm, respectively. Risk of proximity to the mandibular canal should be considered at above heights or greater when an orthodontic anchorage device (OAD) 8 mm in length is placed. Careful attention is needed for placements on lingual side in adolescents. By reducing the OAD length to 6 mm, placement safety increases in all areas except the premolar area, especially on the buccal side.