著者

Haruki Momma Kiminori Kato Susumu S. Sawada Yuko Gando Ryoko Kawakami Motohiko Miyachi Ryoichi Nagatomi Minoru Tashiro Yasuhiro Matsubayashi Satoru Kodama Midori Iwanaga Kazuya Fujihara Hirohito Sone

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20200034, (Released:2020-05-16)

参考文献数

38

被引用文献数

13

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Background: Grip strength reflects systemic muscle strength and mass and is reportedly associated with various metabolic variables. However, its prognostic association with dyslipidemia is unknown. We examined the association of grip strength and other physical fitness markers with the incidence of dyslipidemia among Japanese adults.Methods: A total of 16,149 Japanese (6208 women) individuals aged 20–92 years who underwent a physical fitness test between April 2001 and March 2002 were included in this cohort study. Grip strength, vertical jump, single-leg balance with eyes closed, forward bending, and whole-body reaction time were evaluated at baseline. Dyslipidemia was annually determined based on fasting serum lipid profiles and self-reported dyslipidemia from April 2001 to March 2008.Results: During the follow-up period, 4458 (44.9%) men and 2461 (39.6%) women developed dyslipidemia. A higher relative grip strength (grip strength/body mass index) was associated with a lower incidence of dyslipidemia among both men and women (P for trend < 0.001). Compared with those for the first septile, the hazards ratios and 95% confidence intervals for the seventh septile were 0.56 (0.50, 0.63) for men and 0.69 (0.58, 0.81) for women. Moreover, relative vertical jump (vertical jump strength/body mass index) was also inversely associated with the incidence of dyslipidemia among both men and women (P for trend < 0.001). There was no association between other physical fitness and dyslipidemia among both men and women.Conclusion: Relative grip strength and vertical jump may be useful risk markers of the incidence of dyslipidemia.

著者

Haruki Momma Susumu S Sawada Kiminori Kato Yuko Gando Ryoko Kawakami Motohiko Miyachi Cong Huang Ryoichi Nagatomi Minoru Tashiro Masahiro Ishizawa Satoru Kodama Midori Iwanaga Kazuya Fujihara Hirohito Sone

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20170280, (Released:2018-07-28)

参考文献数

40

被引用文献数

37

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Background: Simple physical fitness test can be a useful potential predictor of type 2 diabetes (T2DM). We examined the association between performances on simple physical fitness tests and the incidence of T2DM.Methods: This longitudinal study was conducted in 21,802 nondiabetic Japanese (6,649 women) aged 20 to 92 years, who underwent all physical fitness tests at baseline (April 2001 to March 2002). From April 2001 to March 2008, physical fitness tests, including grip strength, vertical jump, single-leg balance with eyes closed, forward bending, whole-body reaction time, and supine legs-up, were performed every year. Participants had physical fitness tests at least two times during the period. T2DM was also annually determined based on fasting blood glucose, glycated hemoglobin, and self-reported diabetes during the period. Discrete-time logit models were used to examine the influence of the serial level of each physical fitness test on the incidence of T2DM.Results: During the entire study period, 972 participants developed diabetes. Lower relative grip strength (grip strength/body weight) and single-leg balance performance were associated with a higher incidence of T2DM. For relative grip strength, as compared with the fourth quartile group, the odds ratios for other groups ranged from 1.16 to 1.56 (P for trend < 0.001). For single-leg balance, the odds ratios ranged from 1.03 to 1.49 (P for trend < 0.001).Conclusion: The performance of a simple single-leg balance test as well as that of a grip strength test were negatively associated with the risk of T2DM among Japanese.

著者

Yuichi Makino Chikayoshi Tani Naoyuki Miyokawa Ryota Yoshimoto Katsutoshi Mizumoto Kohei Eguchi Daisuke Fujishiro Satoru Kodama Atsushi Kobayashi Keiji Komura Kensaku Okamoto Hiroyuki Furukawa Masakazu Haneda

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.54, no.22, pp.2851-2855, 2015 (Released:2015-11-15)

参考文献数

16

被引用文献数

1 4

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A 47-year-old woman with a 2-year history of rheumatoid arthritis (RA) undergoing methotrexate treatment developed a perforated ulcer in the ileum for which she underwent emergency surgery. A histological analysis of the extirpated specimen presented a possible Epstein-Barr virus (EBV) infection in the ulcerative lesion without a feature of lymphoproliferative disorder. Interestingly, the patient's serological tests with a paired serum diagnosed a primary EBV infection. The present case emphasizes the importance of being aware of severe enteritis as a possibility for patients with RA, for an accurate diagnosis.

著者

Satoru Kodama Kazumi Saito Shiro Tanaka Chika Horikawa Kazuya Fujiwara Reiko Hirasawa Yoko Yachi Yasuko Sone Kaoruko Tada Iida Hitoshi Shimano Yasuo Ohashi Nobuhiro Yamada Hirohito Sone

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

vol.19, no.4, pp.385-396, 2012 (Released:2012-04-26)

参考文献数

50

被引用文献数

3 17 4

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Aim: The post-challenge glucose (PCG) level has been suggested to be superior to the fasting blood glucose (FG) level for predicting the risk of future cardiovascular disease (CVD); however, the extent of its superiority has not been consistently shown among previous cohort studies. Therefore, we conducted a meta-analysis to summarize the quantitative association of FG and PCG with CVD risk and compared the strengths of the two associations.Method: Electronic literature searches using MEDLINE and EMBASE with an additional manual search were conducted for prospective observational studies of the association of FG and PCG with CVD risk. Studies were included if they were prospective studies in which the relative risk (RR) of CVD per 1 standard deviation increase in both FG and PCG could be estimated. Pooled relative risks for the incremental increase were calculated as RRFG and RRPCG using a bivariate random-effects model.Result: Data were obtained from 14 eligible studies that included 70,889 participants and 2,927 cases. The pooled RRFG and RRPCG (95% confidence interval) were, respectively, 1.15 (1.06 to 1.26) and 1.24 (1.12 to 1.36); the difference was significant (P =0.001). The association of PCG with CVD risk was stronger in studies that targeted participants with a baseline mean FG < 100 mg/dl (P < 0.001) or mean age ≥ 55 years (P =0.004).Conclusions: Overall, the association of PCG with CVD risk was stronger than that of FG by approximately 50% on a log scale. Measuring PCG is especially important in populations with relatively low FG levels or in the elderly, although it is often burdensome in routine clinical practice.