著者

Zhongyu Ren Cong Huang Haruki Momma Yufei Cui Kaijun Niu Shota Sugiyama Masakazu Nanno Ryoichi Nagatomi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20170029, (Released:2018-04-21)

参考文献数

31

被引用文献数

5

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Background: There is scarce epidemiological evidence regarding the relationships of the consumption of different types of vegetables or fruits with change in skeletal muscle strength. We prospectively examined the relationships among Japanese adults, using handgrip strength to assess skeletal muscle strength.Methods: A 3-year study was carried out with 259 Japanese adults who were 22–68 years of age. The frequency of consumption of different types of vegetables or fruits were obtained using a validated self-administered dietary history questionnaire. Handgrip strength was measured with a handheld digital Smedley dynamometer.Results: After adjustment for confounding factors, the mean change in handgrip strength in participants stratified according to the level of tomato and tomato product consumption at baseline were −3.2 (95% confidence interval [CI], −4.0 to −2.3) for <1 time/week, −2.7 (95% CI, −3.6 to −1.8) for 1 time/week, −1.6 (95% CI, −2.5 to −0.8) for 2–3 times/week, and −1.7 (95% CI, −2.8 to −0.7) for ≥4 times/week, (P for trend = 0.022). However, the significant relationships of consumption of other types of vegetables and different types of fruits with change in handgrip strength were not observed.Conclusion: Higher consumption of tomato and tomato product at baseline was significantly associated with reduced decline in handgrip strength among Japanese adults over a 3-year follow-up period. This study suggests that consumption of tomato and tomato product could be protective against the decline in skeletal muscle strength associated with aging.

著者

Haruki Momma Kiminori Kato Susumu S. Sawada Yuko Gando Ryoko Kawakami Motohiko Miyachi Ryoichi Nagatomi Minoru Tashiro Yasuhiro Matsubayashi Satoru Kodama Midori Iwanaga Kazuya Fujihara Hirohito Sone

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20200034, (Released:2020-05-16)

参考文献数

38

被引用文献数

13

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Background: Grip strength reflects systemic muscle strength and mass and is reportedly associated with various metabolic variables. However, its prognostic association with dyslipidemia is unknown. We examined the association of grip strength and other physical fitness markers with the incidence of dyslipidemia among Japanese adults.Methods: A total of 16,149 Japanese (6208 women) individuals aged 20–92 years who underwent a physical fitness test between April 2001 and March 2002 were included in this cohort study. Grip strength, vertical jump, single-leg balance with eyes closed, forward bending, and whole-body reaction time were evaluated at baseline. Dyslipidemia was annually determined based on fasting serum lipid profiles and self-reported dyslipidemia from April 2001 to March 2008.Results: During the follow-up period, 4458 (44.9%) men and 2461 (39.6%) women developed dyslipidemia. A higher relative grip strength (grip strength/body mass index) was associated with a lower incidence of dyslipidemia among both men and women (P for trend < 0.001). Compared with those for the first septile, the hazards ratios and 95% confidence intervals for the seventh septile were 0.56 (0.50, 0.63) for men and 0.69 (0.58, 0.81) for women. Moreover, relative vertical jump (vertical jump strength/body mass index) was also inversely associated with the incidence of dyslipidemia among both men and women (P for trend < 0.001). There was no association between other physical fitness and dyslipidemia among both men and women.Conclusion: Relative grip strength and vertical jump may be useful risk markers of the incidence of dyslipidemia.

著者

Haruki Momma Susumu S Sawada Kiminori Kato Yuko Gando Ryoko Kawakami Motohiko Miyachi Cong Huang Ryoichi Nagatomi Minoru Tashiro Masahiro Ishizawa Satoru Kodama Midori Iwanaga Kazuya Fujihara Hirohito Sone

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20170280, (Released:2018-07-28)

参考文献数

40

被引用文献数

37

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Background: Simple physical fitness test can be a useful potential predictor of type 2 diabetes (T2DM). We examined the association between performances on simple physical fitness tests and the incidence of T2DM.Methods: This longitudinal study was conducted in 21,802 nondiabetic Japanese (6,649 women) aged 20 to 92 years, who underwent all physical fitness tests at baseline (April 2001 to March 2002). From April 2001 to March 2008, physical fitness tests, including grip strength, vertical jump, single-leg balance with eyes closed, forward bending, whole-body reaction time, and supine legs-up, were performed every year. Participants had physical fitness tests at least two times during the period. T2DM was also annually determined based on fasting blood glucose, glycated hemoglobin, and self-reported diabetes during the period. Discrete-time logit models were used to examine the influence of the serial level of each physical fitness test on the incidence of T2DM.Results: During the entire study period, 972 participants developed diabetes. Lower relative grip strength (grip strength/body weight) and single-leg balance performance were associated with a higher incidence of T2DM. For relative grip strength, as compared with the fourth quartile group, the odds ratios for other groups ranged from 1.16 to 1.56 (P for trend < 0.001). For single-leg balance, the odds ratios ranged from 1.03 to 1.49 (P for trend < 0.001).Conclusion: The performance of a simple single-leg balance test as well as that of a grip strength test were negatively associated with the risk of T2DM among Japanese.

著者

Yutaka Yabe Yoshihiro Hagiwara Takuya Sekiguchi Haruki Momma Masahiro Tsuchiya Kaoru Kuroki Kenji Kanazawa Masashi Koide Nobuyuki Itaya Shinichiro Yoshida Yasuhito Sogi Toshihisa Yano Eiji Itoi Ryoichi Nagatomi

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.244, no.4, pp.297-304, 2018 (Released:2018-04-10)

参考文献数

29

被引用文献数

1 9

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Verbal or physical abuse from coaches has a negative impact on young athletes. To prevent abuse against young athletes, it is important to know the characteristics of abusive coaches. This study aimed to elucidate the characteristics of coaches who commit verbal or physical abuse in youth sports teams. A cross-sectional study was conducted with coaches of youth sport teams in Miyagi prefecture, Japan (n = 1,283), using a self-reported questionnaire (response rate was 24.0%). Multivariate logistic regression models were used for analyses. The prevalence of verbal and physical abuse towards young athletes was 64.7% (n = 830) and 6.2% (n = 79), respectively. Verbal abuse was significantly associated with lower educational attainment (odds ratio (OR): 1.32, 95% confidence interval (95% CI): 1.03-1.69), experiences of verbal abuse by own coaches (OR: 1.85, 95% CI: 1.37-2.50), acceptability for verbal or physical abuse (OR: 2.53, 95% CI: 1.82-3.52), and dissatisfaction with athletes’ attitude (OR: 1.62, 95% CI: 1.26-2.07). Physical abuse was significantly associated with experiences of physical abuse by respondents’ coaches (OR: 2.71, 95% CI: 1.50-4.92), acceptability for verbal or physical abuse (OR: 3.89, 95% CI: 2.39-6.33), and longer experience of coaching in years (OR: 2.45, 95% CI: 1.20-4.98). The results of this study show that coaches who commit verbal or physical abuse had typically experienced abuse from their former coaches, and adopted a similar style. Breaking the negative cycle of verbal and physical abuse is necessary to eliminate the abuse of young athletes.

著者

Haruki Momma Susumu S. Sawada Robert A. Sloan Yuko Gando Ryoko Kawakami Shin Terada Motohiko Miyachi Chihiro Kinugawa Takashi Okamoto Koji Tsukamoto Cong Huang Ryoichi Nagatomi Steven N. Blair

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20160199, (Released:2017-11-25)

参考文献数

29

被引用文献数

6

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Background: The “Physical Activity Reference for Health Promotion 2013” provides “fit” reference values for cardiorespiratory fitness (CRF) for good health. The importance of achieving a fit CRF level for several years on the subsequent prevention of type 2 diabetes mellitus (T2DM) remains to be clarified.

著者

Mutsuo Yamaya Hidekazu Nishimura Xue Deng Akiko Kikuchi Ryoichi Nagatomi

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.251, no.1, pp.27-30, 2020 (Released:2020-05-22)

参考文献数

24

被引用文献数

13

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The number of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has rapidly increased, although the WHO declared a pandemic. However, drugs that function against SARS-CoV-2 have not been established. SARS-CoV-2 has been suggested to bind angiotensin-converting enzyme 2, the receptor of the SARS coronavirus. SARS coronavirus and coronavirus 229E, the cause of the common cold, replicate through cell-surface and endosomal pathways using a protease, the type II transmembrane protease. To examine the effects of protease inhibitors on the replication of coronavirus 229E, we pretreated primary cultures of human nasal epithelial (HNE) cells with camostat or nafamostat, each of which has been used for the treatment of pancreatitis and/or disseminated intravascular coagulation. HNE cells were then infected with coronavirus 229E, and viral titers in the airway surface liquid of the cells were examined. Pretreatment with camostat (0.1-10 μg/mL) or nafamostat (0.01-1 μg/mL) reduced the titers of coronavirus 229E. Furthermore, a significant amount of type II transmembrane protease protein was detected in the airway surface liquid of HNE cells. Additionally, interferons have been reported to have antiviral effects against SARS coronavirus. The additive effects of interferons on the inhibitory effects of other candidate drugs to treat SARS-CoV-2 infection, such as lopinavir, ritonavir and favipiravir, have also been studied. These findings suggest that protease inhibitors of this type may inhibit coronavirus 229E replication in human airway epithelial cells at clinical concentrations. Protease inhibitors, interferons or the combination of these drugs may become candidate drugs to inhibit the replication of SARS-CoV-2.

著者

Takuya Sekiguchi Yoshihiro Hagiwara Haruki Momma Masahiro Tsuchiya Kaoru Kuroki Kenji Kanazawa Yutaka Yabe Shinichiro Yoshida Masashi Koide Nobuyuki Itaya Eiji Itoi Ryoichi Nagatomi

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.243, no.3, pp.173-178, 2017 (Released:2017-11-21)

参考文献数

35

被引用文献数

1 23

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Elbow or shoulder injuries are common in overhead sports. Because energy derived from the lower extremity passes through the trunk to the upper extremity in overhead motion, a break in such a kinetic chain could lead to arm injuries. However, there is only limited information about the role of the trunk and lower extremity support in preventing elbow or shoulder injuries. This study aimed to explore the association of trunk and lower extremity pain with elbow/shoulder pain among young overhead athletes. We conducted a cross-sectional study using self-reported questionnaires mailed to young athletes belonging to the Miyagi Amateur Sports Association. The final study population comprised 2,215 young athletes playing baseball (n = 1,422), volleyball (n = 546), softball (n = 14), handball (n = 28), tennis (n = 110), or badminton (n = 95). The median age of the participants was 11 years (range: 6 to 15 years). Multiple logistic regression analysis revealed the higher prevalence of elbow and/or shoulder pain in athletes with back pain (OR = 5.52, 95% CI = 3.51-8.69), hip pain (OR = 6.13, 95% CI = 3.35-11.22), knee pain (OR = 2.28, 95% CI = 1.48-3.51), and foot pain (OR = 3.03, 95% CI = 1.95-4.72), compared with those without pain. We propose that trunk or lower extremity pain is significantly associated with elbow or shoulder pain among young overhead athletes. Assessing for pain in trunk or lower extremity, as well as elbow and/or shoulder pain, may help prevent serious injuries in young overhead athletes.

著者

Zhongyu Ren Cong Huang Haruki Momma Yufei Cui Kaijun Niu Shota Sugiyama Masakazu Nanno Ryoichi Nagatomi

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

vol.28, no.9, pp.397-403, 2018-09-05 (Released:2018-09-05)

参考文献数

31

被引用文献数

5

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Background: There is scarce epidemiological evidence regarding the relationships of the consumption of different types of vegetables or fruits with change in skeletal muscle strength. We prospectively examined the relationships among Japanese adults, using handgrip strength to assess skeletal muscle strength.Methods: A 3-year study was carried out with 259 Japanese adults who were 22–68 years of age. The frequency of consumption of different types of vegetables or fruits were obtained using a validated self-administered dietary history questionnaire. Handgrip strength was measured with a handheld digital Smedley dynamometer.Results: After adjustment for confounding factors, the mean change in handgrip strength in participants stratified according to the level of tomato and tomato product consumption at baseline were −3.2 (95% confidence interval [CI], −4.0 to −2.3) for <1 time/week, −2.7 (95% CI, −3.6 to −1.8) for 1 time/week, −1.6 (95% CI, −2.5 to −0.8) for 2–3 times/week, and −1.7 (95% CI, −2.8 to −0.7) for ≥4 times/week, (P for trend = 0.022). However, the significant relationships of consumption of other types of vegetables and different types of fruits with change in handgrip strength were not observed.Conclusion: Higher consumption of tomato and tomato product at baseline was significantly associated with reduced decline in handgrip strength among Japanese adults over a 3-year follow-up period. This study suggests that consumption of tomato and tomato product could be protective against the decline in skeletal muscle strength associated with aging.