- 著者
- Andy CRUMP Satoshi OMURA
- 出版者
- The Japan Academy
- 雑誌
- Proceedings of the Japan Academy, Series B (ISSN:03862208)
- 巻号頁・発行日
- vol.87, no.2, pp.13-28, 2011-02-10 (Released:2011-02-10)
- 参考文献数
- 68
- 被引用文献数
- 115 235
Discovered in the late-1970s, the pioneering drug ivermectin, a dihydro derivative of avermectin—originating solely from a single microorganism isolated at the Kitasato Intitute, Tokyo, Japan from Japanese soil—has had an immeasurably beneficial impact in improving the lives and welfare of billions of people throughout the world. Originally introduced as a veterinary drug, it kills a wide range of internal and external parasites in commercial livestock and companion animals. It was quickly discovered to be ideal in combating two of the world’s most devastating and disfiguring diseases which have plagued the world’s poor throughout the tropics for centuries. It is now being used free-of-charge as the sole tool in campaigns to eliminate both diseases globally. It has also been used to successfully overcome several other human diseases and new uses for it are continually being found. This paper looks in depth at the events surrounding ivermectin’s passage from being a huge success in Animal Health into its widespread use in humans, a development which has led many to describe it as a “wonder” drug.(Contributed by Satoshi OMURA, M.J.A.)
- 著者
- Satoshi OMURA Juichi AWAYA
- 出版者
- Japan Oil Chemists' Society
- 雑誌
- Journal of Japan Oil Chemists' Society (ISSN:18842003)
- 巻号頁・発行日
- vol.28, no.2, pp.75-80, 1979-02-20 (Released:2009-11-10)
- 参考文献数
- 29
1 0 0 0 OA ANTIVIRAL ACTIVITIES OF PENTALENOLACTONES
- 著者
- AKIRA NAKAGAWA HIROSHI TOMODA MAI VAN HAO KEIKO OKANO YUZURU IWAI SATOSHI OMURA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.38, no.8, pp.1114-1115, 1985 (Released:2006-04-19)
- 参考文献数
- 6
- 被引用文献数
- 22 22
1 0 0 0 OA CHEMICAL MODIFICATION OF SPIRAMYCINS
- 著者
- HIROSHI SANO TOSHIAKI SUNAZUKA HARUO TANAKA KINYA YAMASHITA RYO OKACHI SATOSHI OMURA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.38, no.10, pp.1350-1358, 1985 (Released:2006-04-19)
- 参考文献数
- 5
- 被引用文献数
- 6 9
3, 3"-Di-O-acyl-4"-O-sulfonyl and 3, 3"-di-O-acyl-4"-O-alkyl derivatives of spiramycin I were synthesized and evaluated by four parameters, antibacterial activity, affinity to ribosomes, lypophilicity and therapeutic effects. Among them, 3, 3"-di-O-acetyl-4"-O-mesyl and 3, 3"-di-O-acetyl-4"-O-methylspiramycin I having relatively small substituents at 4"-position were the most effective in mouse protection tests, and the results were comparable to acetylspiramycin.
1 0 0 0 OA Superoxide dismutase produced by soil bacteria increases bacterial colony growth from soil samples
- 著者
- Yoko Takahashi Shogo Katoh Noriyasu Shikura Hiroshi Tomoda Satoshi Omura
- 出版者
- Applied Microbiology, Molecular and Cellular Biosciences Research Foundation
- 雑誌
- The Journal of General and Applied Microbiology (ISSN:00221260)
- 巻号頁・発行日
- vol.49, no.4, pp.263-266, 2003 (Released:2005-03-18)
- 参考文献数
- 11
- 被引用文献数
- 21 31