- 著者
- Kenji Suzuki Katsuhiro Nakagawa Tetsuya Kawano Shuichi Mori Masaki Katsumata Fadli Syamsudin Kunio Yoneyama
- 出版者
- Meteorological Society of Japan
- 雑誌
- SOLA (ISSN:13496476)
- 巻号頁・発行日
- vol.14, pp.148-152, 2018 (Released:2018-10-17)
- 参考文献数
- 20
- 被引用文献数
- 3
Videosonde observations were conducted at the southwestern coastal region of Sumatra Island, Indonesia, as part of a pilot field campaign of the Years of the Maritime Continent project (Pre-YMC), to investigate the role of solid hydrometeor for precipitation processes in clouds. Videosondes were launched into three types of clouds: convective and stratiform clouds, and a thick upper stratiform cloud with shallow convection at lower level. A quantitative evaluation of the graupel shape data obtained from the videosondes showed different graupel formations in different rain systems. For the typical stratiform cloud, almost no graupel was observed. In contrasts, for the thick upper stratiform clouds with shallow convection, large numbers of ice crystals in the upper layer suggested to act as embryos and form a lot of graupel with the riming of the supercooled droplets that was supposed to be provided from the shallow convection. On the other hand, for the convection case, the videosonde observed spherical graupel just above the freezing level. This suggested that frozen drops acting as embryos formed spherical graupel, which were uplifted by the strong updraft in the convective cloud, and were different from the generally irregular-shaped graupel in the thick upper stratiform cloud.
- 著者
- Peiming Wu Dodi Ardiansyah Satoru Yokoi Shuichi Mori Fadli Syamsudin Kunio Yoneyama
- 出版者
- Meteorological Society of Japan
- 雑誌
- SOLA (ISSN:13496476)
- 巻号頁・発行日
- vol.13, pp.36-40, 2017 (Released:2017-03-24)
- 参考文献数
- 17
- 被引用文献数
- 9 16
This study examined the impact of an active phase of the Madden–Julian Oscillation (MJO) on a torrential rain event that occurred on the western coast of Sumatra Island on 12 December 2015, using surface meteorological observations, meteorological radar observations, and balloon sounding data obtained from the pre-Years of the Maritime Continent field campaign. Strong MJO activity took place in mid-December 2015 into January 2016. Radar observations revealed that a convergence and convective cloud merger of mesoscale convective systems from an eastward propagating MJO and westward moving diurnal convection over the western coast of the island was the immediate cause of the torrential rain. An investigation of the occurrence of convection over the island showed that both westward moving diurnal convection from the mountains and eastward propagating convection from the Indian Ocean occurred on 12 December, because the westerly winds in the lower troposphere associated with the MJO were only just initiated and were weak on the day. The results suggest that the leading edge of the MJO westerly wind bursts provided favorable conditions for an active phase of the MJO to work with the westward moving diurnal convection and cause torrential rain on the western coast of Sumatra Island.
- 著者
- Kazuma Kaitoh Aki Nakatsu Shuichi Mori Hiroyuki Kagechika Yuichi Hashimoto Shinya Fujii
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.67, no.6, pp.566-575, 2019-06-01 (Released:2019-06-01)
- 参考文献数
- 33
- 被引用文献数
- 9
We report here the development of phenylamino-1,3,5-triazine derivatives as novel nonsteroidal progesterone receptor (PR) antagonists. PR plays key roles in various physiological systems, including the female reproductive system, and PR antagonists are promising candidates for clinical treatment of multiple diseases. By using the phenylamino-1,3,5-triazine scaffold as a template structure, we designed and synthesized a series of 4-cyanophenylamino-1,3,5-triazine derivatives. The synthesized compounds exhibited PR antagonistic activity, and among them, compound 12n was the most potent (IC50 = 0.30 µM); it also showed significant binding affinity to the PR ligand-binding domain. Docking simulation supported the design rationale of the compounds. Our results suggest that the phenylamino-1,3,5-triazine scaffold is a versatile template for development of nonsteroidal PR antagonists and that the developed compounds are promising lead compounds for further structural development of nonsteroidal PR antagonists.
- 著者
- Shuichi Mori Ryohei Takagaki Shinya Fujii Ko Urushibara Aya Tanatani Hiroyuki Kagechika
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.65, no.11, pp.1051-1057, 2017-11-01 (Released:2017-11-01)
- 参考文献数
- 39
- 被引用文献数
- 3
The progesterone receptor (PR) controls various physiological processes, including the female reproductive system, and nonsteroidal PR ligands are considered to be drug candidates for treatment of various diseases without significant adverse effects. Here, we designed and synthesized m-carborane-based secondary alcohols and investigated their PR-ligand activity. All the synthesized alcohols exhibited PR-antagonistic activity at subnanomolar concentration. Among them, alcohols having a small alkyl side chain and a 4-cyanophenyl group also exhibited PR-agonistic activity in a relatively high concentration range. Optical resolution of secondary alcohols having a methyl side chain was performed, and the PR-ligand activity and PR-binding affinity of the purified enantiomers were examined. The chirality of the secondary alcohol appears to have a more significant influence on PR-agonistic activity than on antagonistic activity.