- 著者
- Chihiro Takai Kayo Misumi Daiki Kaito Hiroaki Nishida Masami Yoshii So Yamada Takaomi Kobayashi Toshitaka Koinuma Takashi Kadoya Takuya Kimura Yoshihiro Hagiwara Takayuki Ogura
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.62, no.8, pp.1185-1189, 2023-04-15 (Released:2023-04-15)
- 参考文献数
- 25
- 被引用文献数
- 2
Lacosamide is an antiepileptic drug that acts on voltage-gated sodium channels and was approved as an antiepileptic by the Food and Drug Administration in 2008. Although the efficacy and safety of lacosamide have been established in many previous trials, some case reports have shown that it may lead to cardiovascular side effects, especially in patients with electrical conduction system disorders. We herein report a case of life-threatening cardiac arrhythmia caused by lacosamide intoxication that was successfully treated with veno-arterial extracorporeal membrane oxygenation.
- 著者
- So Yamada Yuki Matsumuro Takashi Inoue Tomonori Kitamura Saki Itonori Mutsumi Sugita Masahiro Ito
- 出版者
- 公益社団法人 日本油化学会
- 雑誌
- Journal of Oleo Science (ISSN:13458957)
- 巻号頁・発行日
- vol.56, no.3, pp.129-136, 2007 (Released:2007-02-10)
- 参考文献数
- 36
- 被引用文献数
- 2 4
A novel sulfated glycosphingolipid, SGL-1, was isolated from the ascidian Ciona intestinalis, prepared from chloroform/methanol extracts and fractionated successively on DEAE Sephadex-A25, Florisil and Iatrobeads column chromatographies. Chemical structural analysis was performed using methylation analysis, gas-liquid chromatography, combined gas-liquid chromatography-mass spectrometry, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 1H-NMR spectroscopy. This chemical structure is presented as GlcCer I6-Sulfate. The ceramide moiety was specified by t16:0, t17:0, br,t17:0, t18:0 and br,t18:0 as sphingoids, and 2-hydroxy, saturated fatty acids as represented by docosanoic and tetracosanoic acids.