著者

Manabu Kondo Yuka Miyoshi Kohji Tarumoto Norie Hirayama Takahiro Sasaki Kohji Yamashita Susumu Yamashita Katsuhiro Hatao

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.57, no.14, pp.2041-2043, 2018-07-15 (Released:2018-07-15)

参考文献数

10

被引用文献数

1

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Quinolones are known to induce hypoglycemia, although there is no written report of garenoxacin-induced hypoglycemia. We herein report a case of garenoxacin-induced hypoglycemia in a patient not taking hypoglycemic drugs. An 89-year-old Japanese woman with type 2 diabetes and chronic renal insufficiency requiring hemodialysis was admitted to the emergency department in a comatose state. Her serum glucose measured 1 mg/dL on arrival. The patient had not taken any hypoglycemic drugs recently and had never experienced a hypoglycemic episode. She had received a four-day course of garenoxacin treatment before the emergency admission. Clinicians should therefore recognize the potential risk of hypoglycemia during garenoxacin therapy.

著者

Shinichiro UESAWA Susumu YAMASHITA Mitsuhiko SHIBATA Hiroyuki YOSHIDA

出版者

The Japan Society of Mechanical Engineers

雑誌

Mechanical Engineering Journal (ISSN:21879745)

巻号頁・発行日

vol.5, no.4, pp.18-00115, 2018 (Released:2018-08-15)

参考文献数

17

被引用文献数

2

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A dry method is one of fuel debris retrieval methods for decommissioning of TEPCO’s Fukushima Daiichi nuclear power station. However, the cooling of fuel debris must be fully maintained without water. Japan Atomic Energy Agency (JAEA) has evaluated the air-cooling performance of the fuel debris in the dry method by using JUPITER. Because JUPITER can represent the relocation of the corium, the unknown parameters, such as the composition and the position of the fuel debris at the RPV pedestal, can be reduced. By calculating the heat transfer of the fuel debris based on the corium relocation obtained with JUPITER, more accurate analysis of the air-cooling performance of the fuel debris in the dry method is expected. In order to evaluate the air-cooling performance of fuel debris in the dry method by using JUPITER, the validation of the free-convective heat transfer analysis of JUPITER were performed in this paper. In order to qualitatively evaluate results of JUPITER for configurations closer to experimental conditions and to decide physical values and positions to be measured in the validation, JUPITER was compared with OpenFOAM for the simple cuboid configuration which has the heating and cooling surfaces at the floor and the ceiling, respectively. The comparison proved that JUPITER can calculate the vertical temperature distribution as well as OpenFOAM on the condition of the lower heating amount. In the validation, JUPITER was compared with the heat transfer experiments of free convection in air adjacent to an upward-facing horizontal heating surface. The comparison proved that JUPITER was in good agreement with the experiment on the condition of the lower heating-surface temperature. The result indicated that JUPITER is a helpful numerical method to evaluate the free-convective heat transfer of the fuel debris in the dry method.

著者

Seiji KAWAMOTO Mitsuoki KANEOKE Kayo OHKOUCHI Yuichi AMANO Yuki TAKAOKA Kazunori KUME Tsunehiro AKI Susumu YAMASHITA Ken-ichi WATANABE Motoni KADOWAKI Dai HIRATA Kazuhisa ONO

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.75, no.1, pp.140-144, 2011-01-23 (Released:2011-01-23)

参考文献数

15

被引用文献数

22

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We tested the effect of oral administration of fermented sake lees with lactic acid bacteria (FESLAB) on a murine model of allergic rhinitis upon immunization and nasal sensitization with ovalbumin (OVA). We used Lactobacillus paracasei NPSRIk-4 (isolated from sake lees), and L. brevis NPSRIv-8 (from fermented milk) as starter strains to produce the FESLAB. Oral FESLAB administration resulted in the development of significantly fewer sneezing symptoms than those seen in sham control animals given sterile water. We also found that FESLAB suppressed the allergen-induced degranulation of RBL2H3 rat basophilic leukemia cells.