著者

田中 綾 山田 航 TANAKA Aya YAMADA Wataru

出版者

北海学園大学人文学会

雑誌

北海学園大学人文論集 (ISSN:09199608)

巻号頁・発行日

no.55, pp.158-104, 2013-08

著者

田中 綾 TANAKA Aya

出版者

北海学園大学人文学会

雑誌

北海学園大学人文論集 (ISSN:09199608)

巻号頁・発行日

no.59, pp.178-152, 2015-08

著者

Yang Weiwen Itoh Fumiko Ohya Hirotoshi Kishimoto Fukiko Tanaka Aya Nakano Naoko Itoh Susumu Kato Mitsuyasu

出版者

Wiley-Blackwell

雑誌

Cancer science (ISSN:13479032)

巻号頁・発行日

vol.102, no.10, pp.1808-1814, 2011-10

被引用文献数

8 2

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he basic helix–loop–helix protein E2-2 is known to play a role in quiescence of endothelial cells (ECs). However, it is unclear how the activity of E2-2 is controlled in the cells. In this study, we identified FAM96B as an interaction partner of E2-2. FAM96B interfered with E2-2-mediated effects on luciferase reporter activities. Furthermore, the suppression of vascular endothelial growth factor receptor 2 promoter activity by E2-2 was rescued by the expression of FAM96B in a dose-dependent manner. Interestingly, FAM96B decreased the expression of ectopic and endogenous E2-2 proteins. Mutational analysis revealed that the middle region of FAM96B is required for the limited expression of E2-2 protein. When FAM96B was expressed in ECs, the EC migration, proliferation, and tube formation were potentiated. Taken together, these findings suggest that FAM96B acts as a regulator of E2-2 through the control of its protein expression.