著者

Hashimoto Takaharu Aga Hajime Tabuchi Akihiko Shibuya Takashi Chaen Hiroto Fukuda Shigeharu Kurimoto Masashi

出版者

日本生薬学会

雑誌

生薬學雜誌 (ISSN:13403443)

巻号頁・発行日

vol.52, no.6, pp.518-520, 1998-12-20

被引用文献数

3

---

An ethanol extract from Brazilian propolis had antibacterial activity on Helicobacter pyroli, from which two active fractions were obtained by silica gel column chromatography. From one fraction, an anti-H. pylori compound was isolated which was identified as 4-hydroxycinnamic acid (p-coumaric acid: 1), and from the other fraction, 3-prenyl-4-hydroxy-cinnamic acid, 3-prenyl-4-dihydrocinnamoloxycinnamic acid, and 3,5-diprenyl-4-hydroxycinnamic acid were isolated, whose anti-H. pylori activities expressed as the minimal inhibitory concentration (MIC) in μg/ml, were 15.6〜31.3, 62.5, 125, and 250, respectively. 4-Hydroxycinnamic acid derivatives are likely to be major anti-H. pylori compounds in Brazilian propolis.