- 著者
- Takaaki Sakai Shinichiro Miura
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Reports (ISSN:24340790)
- 巻号頁・発行日
- vol.1, no.7, pp.286-295, 2019-07-10 (Released:2019-07-10)
- 参考文献数
- 47
- 被引用文献数
- 24
Background:Pathogenesis of heart failure with preserved ejection fraction (HFpEF) may involve endothelial dysfunction and abnormal vascular structure. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have beneficial cardiovascular effects and may improve vascular function in patients with HFpEF.Methods and Results:We recruited 184 patients with type 2 diabetes and HFpEF (mean age, 66.0±14.4 years) who were scheduled for treatment with SGLT2 inhibitors, had transthoracic echocardiogram to identify diastolic function, and flow-mediated dilation (FMD) to evaluate endothelial function, and assessed cardio-ankle vascular index (CAVI) and carotid intima-media thickness as indices of vascular function and vascular structure, respectively. Body weight, systolic blood pressure, diastolic blood pressure, triglycerides, remnant lipoprotein cholesterol, fasting plasma glucose, hemoglobin A1c, urinary albumin/creatinine ratio, and insulin resistance (IR) decreased, hematocrit and FMD increased significantly, and CAVI decreased significantly, after 12-week treatment (P<0.05). Short-term SGLT2 inhibitors improved diastolic function, significantly reducing the mitral ratios of septal E/early septal annular tissue Doppler velocity (P=0.003) and lateral E/early lateral e' (P=0.044). On multiple regression statistically significant associations were seen between ∆mean E/e' and ∆FMD, ∆CAVI, and ∆IR.Conclusions:SGLT2 inhibitors can improve diastolic function in patients with type 2 diabetes, suggesting that current treatment policies for diabetes should be re-examined. Further prospective studies with larger sample sizes could provide mechanistic insights into the benefits of SGLT2 inhibitors.
- 著者
- Takaaki Sakai Shinichiro Miura
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Reports (ISSN:24340790)
- 巻号頁・発行日
- pp.CR-19-0018, (Released:2019-07-03)
- 参考文献数
- 47
- 被引用文献数
- 24
Background:Pathogenesis of heart failure with preserved ejection fraction (HFpEF) may involve endothelial dysfunction and abnormal vascular structure. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have beneficial cardiovascular effects and may improve vascular function in patients with HFpEF.Methods and Results:We recruited 184 patients with type 2 diabetes and HFpEF (mean age, 66.0±14.4 years) who were scheduled for treatment with SGLT2 inhibitors, had transthoracic echocardiogram to identify diastolic function, and flow-mediated dilation (FMD) to evaluate endothelial function, and assessed cardio-ankle vascular index (CAVI) and carotid intima-media thickness as indices of vascular function and vascular structure, respectively. Body weight, systolic blood pressure, diastolic blood pressure, triglycerides, remnant lipoprotein cholesterol, fasting plasma glucose, hemoglobin A1c, urinary albumin/creatinine ratio, and insulin resistance (IR) decreased, hematocrit and FMD increased significantly, and CAVI decreased significantly, after 12-week treatment (P<0.05). Short-term SGLT2 inhibitors improved diastolic function, significantly reducing the mitral ratios of septal E/early septal annular tissue Doppler velocity (P=0.003) and lateral E/early lateral e' (P=0.044). On multiple regression statistically significant associations were seen between ∆mean E/e' and ∆FMD, ∆CAVI, and ∆IR.Conclusions:SGLT2 inhibitors can improve diastolic function in patients with type 2 diabetes, suggesting that current treatment policies for diabetes should be re-examined. Further prospective studies with larger sample sizes could provide mechanistic insights into the benefits of SGLT2 inhibitors.
- 著者
- Kohei HOSOI Jong-Eun HONG Takaaki SAKAI Shintaro IDA Tatsumi ISHIHARA
- 出版者
- 公益社団法人 日本セラミックス協会
- 雑誌
- Journal of the Ceramic Society of Japan (ISSN:18820743)
- 巻号頁・発行日
- vol.123, no.1436, pp.182-186, 2015-04-01 (Released:2015-04-01)
- 参考文献数
- 24
- 被引用文献数
- 1 4
Preparation of Microtubular cell using doped lanthanum gallate (LSGM) electrolyte with a dip coating and co-sintering process was studied. In order to suppress Ni diffusion from Ni-based anode substrate to LSGM electrolyte layer, Ti added La-doped ceria (Ti-LDC) was inserted as buffer layer. The amount of Ni diffused in LSGM electrolyte was investigated by EDX analysis as a function of sintering temperatures. It was found that sintering at 1350°C is suitable from the sintering density and the Ni diffusion. The cell sintered at 1350°C exhibited the higher power density than that of the conventional LSGM micro-tubular cell, even though a small amount of Ni diffusion was still observed at the Ti-LDC buffer layer/LSGM electrolyte interface. The micro-tubular cell with around 50 µm thickness showed the open circuit potential higher than 1.0 V and the maximum power density of 0.69, 0.31 and 0.12 W/cm2 at 700, 600 and 500°C, respectively, were achieved.