著者

Takafumi Kubota Tomomi Shijo Kensho Ikeda Yoshihiko Mitobe Shu Umezawa Tatsuro Misu Takafumi Hasegawa Masashi Aoki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.16, pp.2419-2425, 2023-08-15 (Released:2023-08-15)

参考文献数

33

被引用文献数

3

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We herein report a rare case of distal chronic inflammatory demyelinating polyneuropathy (CIDP) following coronavirus disease 2019 (COVID-19) vaccination. A 39-year-old woman with a solitary plasmacytoma developed general weakness 7 days after receiving the second dose of the Pfizer-BioNTech COVID-19 vaccine, which had progressed for 3 months. A neurological examination revealed limb weakness with areflexia. Serological tests identified the presence of IgG antibodies against anti-GM1 and anti-GM2 gangliosides. Comprehensive evaluations met the criteria of distal CIDP. Intravenous immunoglobulin, intravenous methylprednisolone, oral prednisolone, and plasma exchange were administered, and she gradually improved. Physicians should be aware of CIDP as a rare complication of COVID-19 vaccination.

著者

Takafumi Kubota Naoto Sugeno Hirohito Sano Koji Murakami Kensuke Ikeda Tatsuro Misu Masashi Aoki

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.61, no.11, pp.1761-1765, 2022-06-01 (Released:2022-06-01)

参考文献数

16

被引用文献数

7

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Cranial nerve palsy associated with coronavirus disease 2019 (COVID-19) is rare. We herein report the first Asian case of the immediate onset of isolated and unilateral abducens nerve palsy (ANP) accompanied with COVID-19 infection. A 25-year-old man developed diplopia one day after the COVID-19 symptom onset. Neurological examination revealed limitation of left eye abduction without ataxia and hyporeflexia. Negative anti-ganglioside antibody results and mild albuminocytological dissociation were noted. The patient was diagnosed with left ANP accompanied by COVID-19 infection. The ANP spontaneously recovered without treatment. ANP can develop during the early phase of COVID-19 infection and adversely affect patients' quality of life.

著者

Naoto Kuroda Prasannakumar Kanubhai Gajera Hongxuyang Yu Takafumi Kubota

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.9321-22, (Released:2022-05-31)

参考文献数

36

被引用文献数

6

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Objective To investigate seizure control in patients with epilepsy during the coronavirus disease 2019 (COVID-19) pandemic. Method A systematic review and meta-analysis was conducted, and the MEDLINE, EMBASE, CENTRAL, and ClinicalTrials.gov databases were comprehensively searched for relevant studies. Studies that reported seizure control in patients with epilepsy during the COVID-19 pandemic were included. Pooled proportions with 95% confidence intervals (CIs) of patients with epilepsy who experienced seizure worsening during the COVID-19 pandemic were assessed using a random-effects model. The quality of the assessment for each study, heterogeneity between the studies, and publication bias were also evaluated. Subgroup analyses were performed, excluding studies with reports of seizures worsening from caregivers. Results A total of 24 studies with 6,492 patients/caregivers were included in the meta-analysis. The pooled proportion of seizure worsening was 18.5% (95% CI: 13.9-23.6; I2 = 96%; p<0.01). The pooled proportion of seizure worsening in the subgroup analysis was 18.9% (95% CI: 13.5-25.0; I2 = 96%; p<0.01). Conclusion Although the heterogeneity was high, our results showed a relatively high incidence of seizure worsening during the COVID-19 pandemic. During the COVID-19 pandemic, physicians should be aware of the likelihood of worsening seizures in patients with epilepsy.

著者

Takafumi KUBOTA Kenji KONO

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE Transactions on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E104.D, no.1, pp.126-137, 2021-01-01 (Released:2021-01-01)

参考文献数

52

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Build systems are essential tools for developing large software projects. Traditionally, build systems have been designed for high incremental-build performance. However, the longer build times of recent large C++ projects have imposed a requirement on build systems: i.e., unity builds. Unity builds are a build technique for speeding up sequential compilation of many source files by bundling multiple source files into one. Unity builds lead to a significant reduction in build time through removal of redundant parsing of shared header files. However, unity builds have a negative effect on incremental builds because each compiler task gets larger. Our previous study reported existing unity builds overlook many better bundle configurations that improve unity-build performance without increasing the incremental-build time. Motivated by the problem, we present a novel build system for better performance in unity builds. Our build system aims to achieve competitive unity-build performance in full builds with mitigating the negative effect on incremental builds. To accomplish this goal, our build system uses sophisticated bundle strategies developed on the basis of hints extracted from the preprocessed code of each source file. Thanks to the strategies, our build system finds better bundle configurations that improve both of the full-build performance and the incremental-build performance in unity builds. For example, in comparison with the state-of-the-art unity builds of WebKit, our build system improves build performance by 9% in full builds, by 39% in incremental builds, and by 23% in continuous builds that include both types of the builds.

著者

Naoto Kuroda Ayako Shibata Takafumi Kubota

出版者

JAPAN EPILEPSY SOCIETY

雑誌

Epilepsy & Seizure (ISSN:18825567)

巻号頁・発行日

vol.13, no.1, pp.31-35, 2021 (Released:2021-02-26)

参考文献数

17

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The purpose of this review is to describe the impact of COVID-19 on women with epilepsy and how the issues are managed. From a review of relevant literature, we discuss special considerations for women with epilepsy during the COVID-19 crisis, which include menstruation, pregnancy, and living environment. We also propose comprehensive management including menstruation/pregnancy, medications, and mental stress. Through this review, the serious impact of COVID-19 on women with epilepsy is revealed. Epileptologists must understand these burdens in order to provide comprehensive support for women with epilepsy.