- 著者
- Shinozaki Tetsuya Fukuda Toshio Watanabe Hideomi Takagishi Kenji
- 出版者
- 北関東医学会
- 雑誌
- The KITAKANTO medical journal (ISSN:13432826)
- 巻号頁・発行日
- vol.54, no.2, pp.147-151, 2004-05-01
- 被引用文献数
- 1 8
A seventeen-year-old boy was referred to our hospital, complaining of continuous pain of his left wrist joint. Plain roentgenogram showed an osteolytic lesion at the distal end of the radius. An operation in which the tumor was curetted was performed suspecting giant cell tumor. Pathological diagnosis was of a giant cell tumor. One month after the operation, radiological findings showed local recurrence with an expanded lysis. Wide resection of this tumor followed by a vascularized fibular graft was performed. Six months after the second operation, soft part swelling suggesting local recurrence was again prominent. Upper arm amputation was performed because of the bad local condition. The pathological diagnosis of these operative specimens was of giant cell tumor similar to that of the initial specimen. Multiple metastases appeared eight months after the third operation. In spite of intensive treatment, the patient died of respiratory failure. Autopsy revealed that pathological features from metastatic specimens were similar to those of osteosarcoma, not giant cell tumor. When we encounter patients presenting with a giant cell tumor, especially when they are younger than the age at which such lesions usually occur, we should bear in mind the possibility of an osteosarcoma and perform intensive chemotherapy and surgery.
- 著者
- Tsutsumi Shinichi Shimazu Atsushi Miyazaki Kazuko Pan Haiou Koike Chika Yoshida Eri Takagishi Kenji Kato Yukio
- 出版者
- Elsevier
- 雑誌
- Biochemical and Biophysical Research Communications (ISSN:0006291X)
- 巻号頁・発行日
- vol.288, no.2, pp.413-419, 2001-10-26
- 被引用文献数
- 11 473
Mesenchymal stem cells (MSC) that can differentiate to various connective tissue cells may be useful for autologous cell transplantation to defects of bone, cartilage, and tendon, if MSC can be expanded in vitro. However, a short life span of MSC and a reduction in their differentiation potential in culture have limited their clinical application. The purpose of this study is to identify a growth factor(s) involved in self-renewal of MSC and the maintenance of their multilineage differentiation potential. Fibroblast growth factor-2 (FGF-2) markedly increased the growth rate and the life span of rabbit, canine, and human bone marrow MSC in monolayer cultures. This effect of FGF-2 was more prominent in low-density cultures than in high-density cultures. In addition, all MSC expanded in vitro with FGF-2, but not without FGF-2, differentiated to chondrocytes in pellet cultures. The FGF(+) MSC also retained the osteogenic and adipogenic potential throughout many mitotic divisions. These findings suggest that FGFs play a crucial role in self-renewal of MSC.