文献一覧: Takayuki SHIBATA (著者)

2 0 0 0 OA ハンセン病療養所における図書館の役割(下)

著者: 柴田隆行シバタタカユキ Takayuki SHIBATA
出版者: 東洋大学社会学部
雑誌: 東洋大学社会学部紀要 = The Bulletin of Faculty of Sociology,Toyo University (ISSN:04959892)
巻号頁・発行日: vol.47, no.1, pp.61-72, 2010-01

2016-12-17 16:19:37
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http://id.nii.ac.jp/1060/00003082/

2 0 0 0 OA ハンセン病療養所における図書館の役割(上)

著者: 柴田隆行シバタタカユキ Takayuki SHIBATA
出版者: 東洋大学社会学部
雑誌: 東洋大学社会学部紀要 = The Bulletin of Faculty of Sociology,Toyo University (ISSN:04959892)
巻号頁・発行日: vol.46, no.1, pp.203-217, 2008-12

2016-12-17 16:19:36
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http://id.nii.ac.jp/1060/00003063/

1 0 0 0 OA Synthesis and Evaluation of Oligonucleotide-Containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarb-onyl}adenosine as Photo-crosslinkable Gene Targeting Tools

著者: Yu Mikame Yui Sakai Ryo Tahara Kinuka Doi Tsuyoshi Yamamoto Chikara Dohno Takayuki Shibata Asako Yamayoshi
出版者: The Pharmaceutical Society of Japan
雑誌: Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日: pp.c22-00333, (Released:2022-07-28)
参考文献数: 23

Several psoralen-conjugated oligonucleotides (Ps-Oligos) have been developed as photo-crosslinkable oligonucleotides targeting DNA or RNA. To avoid potential off-target effects, it is important to investigate the selective photo-crosslinking reactivity of Ps-Oligos to DNA or RNA. However, the selectivity of these Ps-Oligos has not been reported in detail thus far. In this study, we evaluated the photo-crosslinking properties of two Ps-Oligos, 5’-Ps-Oligo and a novel Ps-Oligo containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarbonyl}adenosine (APs2-Oligo). Notably, 5’-Ps-Oligo preferentially crosslinked with DNA, whereas APs2-Oligo preferentially crosslinked with RNA. These results demonstrate the interesting crosslinking properties of Ps-Oligos, which will provide useful information for the molecular design of novel Ps-Oligos in future studies.