著者

Xiaoxiong Xing Yoshinori Dobashi Tsuyoshi Yamamoto

雑誌

研究報告グラフィクスとCAD(CG)

巻号頁・発行日

vol.2012-CG-147, no.2, pp.1-6, 2012-06-15

---

We present a real-time framework for rendering hair under environment lighting. We precompute the diffuse and specular irradiance environment maps for Kajiya-Kay model with a given environment map, thus reduce the runtime shading computation to simple texture lookups, and we simulate hair self-shadowing by using offline ambient occlusion. In addition, we further achieve runtime editing of the environment map by using spherical harmonic lighting to accelerate the computation of irradiance maps.

著者

Shota Oyama Mao Tomita Moeka Hata Yu Mikame Tsuyoshi Yamamoto Eishi Ashihara Asako Yamayoshi

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.71, no.11, pp.819-823, 2023-11-01 (Released:2023-11-01)

参考文献数

22

---

Exosomes are a type of extracellular vesicles that contain diverse molecules and are present in our body fluids. They play a crucial role in transporting materials and transmitting signals between cells. Currently, there have been numerous reports on the use of exosomes in drug delivery systems (DDS). However, most existing methods for utilizing exosomes in DDS require the isolation and purification of exosomes, which raises concerns about yield and potential damage to the exosomes. Recently, we have developed a novel DDS called “ExomiR-Tracker” that harnesses exosomes without the need for isolation and purification. This system aims to deliver nucleic acid drugs effectively. ExomiR-Tracker consists of an anti-exosome antibody equipped with nona-D-arginines (9 mer) and nucleic acid drugs which have complementary sequence of target microRNA (anti-miR). In this study, we modified ExomiR-Tracker by incorporating branched nona-D-arginines (9 + 9 mer) molecules (referred to as Branch ExomiR-Tracker) and evaluated its efficacy in lung adenocarcinoma cells (A549 cells). The improved complex formation ability and enhanced cellular uptake of anti-miR, demonstrated by our findings, highlight the advantages of incorporating branched oligoarginine peptides into the ExomiR-Tracker platform. These results represent significant progress in revealing the effectiveness of Branch ExomiR-Tracker against adhesive cancer cells, which has not been shown to be effective with the conventional Linear ExomiR-Tracker.

著者

Takayuki KAKIMOTO Satoshi MURAI Noboru KUSAKA Fukiko BABA Yohei INOUE Hayato MIYAKE Masato KAWAKAMI Yukei SHINJI Hisakazu ITAMI Shinji OTSUKA Tsukasa NISHIURA Kenji KAWAMOTO Tsuyoshi YAMAMOTO Nobuhiko KIMURA Kotaro OGIHARA

出版者

The Japan Neurosurgical Society

雑誌

NMC Case Report Journal (ISSN:21884226)

巻号頁・発行日

vol.10, pp.21-25, 2023-12-31 (Released:2023-02-23)

参考文献数

11

---

A 78-year-old man underwent a tracheostomy after embolization for a dural arteriovenous fistula. Seventy days after tracheostomy, arterial bleeding appeared through the tracheal stoma. The bleeding stopped spontaneously. However, two days later, arterial bleeding reappeared, and he was diagnosed with a tracheo-innominate artery fistula (TIF). He then underwent urgent endovascular covered stent placement. After the procedure, there was no bleeding. TIF can be a fatal complication after tracheostomy and it is generally treated with open chest surgery. However, a successful endovascular treatment for TIF has recently been reported and may yield better results.

著者

Kazumasa Oshima Masataka Sakamoto Kazumasa Morita Kenichi Kon Ken-ichi Shimizu Tsuyoshi Yamamoto Masahiro Kishida Shigeo Satokawa

出版者

The Society of Chemical Engineers, Japan

雑誌

JOURNAL OF CHEMICAL ENGINEERING OF JAPAN (ISSN:00219592)

巻号頁・発行日

vol.55, no.7, pp.243-247, 2022-07-20 (Released:2022-07-20)

参考文献数

17

被引用文献数

2

---

The effective utilization of carbon fibers recovered during the thermal decomposition recycling of carbon-fiber-reinforced plastic (CFRP) was investigated. Carbon fibers have a uniform diameter and a suitable size for the use as a combustion catalyst for particulate matter (PM). Thus, in this study, carbon fibers were used as a template to synthesize hollow-form LaNiO3 perovskite-type oxide via the precursor accumulation method. The calcination temperature was lowered by the internal heat supply from the combustion of the carbon template. Hollow-form LaNiO3 exhibited the same chemical properties as LaNiO3 prepared via the common sol–gel method. The morphology of the hollow form decreased the bulk density of the catalyst, resulting in enhanced contact with PM and, consequently, high PM combustion efficiency.

著者

Yu Mikame Yui Sakai Ryo Tahara Kinuka Doi Tsuyoshi Yamamoto Chikara Dohno Takayuki Shibata Asako Yamayoshi

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

pp.c22-00333, (Released:2022-07-28)

参考文献数

23

---

Several psoralen-conjugated oligonucleotides (Ps-Oligos) have been developed as photo-crosslinkable oligonucleotides targeting DNA or RNA. To avoid potential off-target effects, it is important to investigate the selective photo-crosslinking reactivity of Ps-Oligos to DNA or RNA. However, the selectivity of these Ps-Oligos has not been reported in detail thus far. In this study, we evaluated the photo-crosslinking properties of two Ps-Oligos, 5’-Ps-Oligo and a novel Ps-Oligo containing 2’-O-{[(4,5’,8-trimethylpsoralen)-4’-ylmethoxy]ethylaminocarbonyl}adenosine (APs2-Oligo). Notably, 5’-Ps-Oligo preferentially crosslinked with DNA, whereas APs2-Oligo preferentially crosslinked with RNA. These results demonstrate the interesting crosslinking properties of Ps-Oligos, which will provide useful information for the molecular design of novel Ps-Oligos in future studies.

著者

Tsuyoshi YAMAMOTO Eiichi YATSUKA Takaki HATAE Kazuya OTA Yasunori HASHIMOTO Kitaru NAKAMURA Tatsuo SUGIE Masaki TAKEUCHI Sin-iti KITAZAWA Hiroaki OGAWA Yasunori KAWANO Kiyoshi ITAMI

出版者

The Japan Society of Plasma Science and Nuclear Fusion Research

雑誌

Plasma and Fusion Research (ISSN:18806821)

巻号頁・発行日

vol.11, pp.2405114, 2016-10-05 (Released:2017-03-01)

参考文献数

15

---

There is a need to develop ITER instrumentation and control (I&C) systems with high reliabilities. Interlock systems that activate machine protection functions are implemented on robust wired-logic systems such as programmable logic controllers (PLCs). We herein propose a software tool that generates program code templates for the control systems using PLC logic. This tool decreases careless mistakes by developers and increases reliability of the program codes. A large-scale engineering database has been implemented in the ITER project. To derive useful information from this database, we propose adding semantic data to it using the Resource Description Framework format. In our novel proposal for the ITER diagnostic control system, a guide words generator that analyzes the engineering data by inference is applied to the hazard and operability study. We validated the methods proposed in this paper by applying them to the preliminary design for the I&C system of the ITER edge Thomson scattering system.