著者

Takeru SHIMA Tomonori YOSHIKAWA Hayate ONISHI

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.68, no.6, pp.527-532, 2022-12-31 (Released:2022-12-31)

参考文献数

51

被引用文献数

2

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Low-carbohydrate and high-protein (LC-HP) diets are acceptable for improving physiological and metabolic parameters. However, the effects of LC-HP diets on the brain are unclear, which depend on glycometabolism for neuronal activity. Since astrocyte-neuron lactate shuttle (ANLS) is an essential pathway for maintaining brain functions, we investigated the changes in hippocampal memory function. In addition, the alteration of lactate transporter constituting ANLS and ANLS-related neurotrophic factors by feeding LC-HP diets was evaluated in healthy mice. C57BL/6 mice were divided into two groups: a group feeding LC-HP diet (24.6% carbohydrate, 57.6% protein, and 17.8% fat as percentages of calories) and a group feeding control diet (58.6% carbohydrate, 24.2% protein, and 17.2% fat as percentages of calories). Here, we found that 4 wk of LC-HP diet feeding suppressed memory function in mice evaluated by Y-maze. Hippocampal mRNA levels of lactate transporters, such as Mct1, Mct4, and Mct2, were unchanged with feeding LC-HP diets; however, LC-HP diets significantly decreased Dcx and Igf-1 receptor mRNA levels in the hippocampus. Bdnf and its related signaling in mice hippocampus exhibited no change by LC-HP diets. Although there was non-influence in the lactate-transport system, LC-HP diets would suppress hippocampal working memory with dysregulation of neuroplasticity. The current data propose the importance of food choices for maintaining hippocampal health.

著者

Takeru Shima Subrina Jesmin Hayato Nakao Kentaro Tai Tomonori Shimofure Yoshihiro Arai Keiko Kiyama Yoko Onizawa

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.10, no.1, pp.45-49, 2021-01-25 (Released:2021-01-13)

参考文献数

23

被引用文献数

10

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Empathy, which consists of cognitive and affective empathy, is one of the vital skills in humans for creating and maintaining relationships with others, now, there are many empathy-deficient people, possibly deriving from an increase in harassment-related issues. Although there is a possibility that physical activity improves empathy, the association of physical activity with cognitive and affective empathy in healthy humans remains unclear. Thus, the present study aims to clarify the relationship between levels of physical activity and self-reported empathy. Eight hundred and ninety-three responses for two questionnaires, the short version of the International Physical Activity Questionnaire (SV-IPAQ) and Questionnaire of Cognitive and Affective Empathy (QCAE), were analyzed. Levels of physical activity in a usual week were measured based on the SV-IPAQ, and participants were divided into three groups: low, moderate and high physical activity. The scores for cognitive and affective empathy were measured based on QCAE. We found that people with a moderate or high physical activity level show significantly higher self-reported cognitive empathy compared to people with a low physical activity level. The score for self-reported affective empathy wasn’t affected by physical activity level. Physical activity level in a usual week showed a significant positive correlation with self-reported cognitive empathy scores, but not with self-reported affective empathy scores. Our findings imply that an increase in physical activity contributes to better cognitive empathy in healthy young adults.