著者

Masafumi Inyaku Marenao Tanaka Tatsuya Sato Keisuke Endo Kazuma Mori Itaru Hosaka Takuma Mikami Araya Umetsu Hirofumi Ohnishi Yukinori Akiyama Nagisa Hanawa Masato Furuhashi

出版者

Japan Atherosclerosis Society

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.64369, (Released:2023-08-30)

参考文献数

31

被引用文献数

1

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Aim: A high level of directly measured small dense low-density lipoprotein cholesterol (sdLDL-C) is a strong risk factor for ischemic heart disease (IHD). However, it remains unclear whether estimated sdLDL-C level is a predictor for IHD. We investigated the associations of new onset of IHD with levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TG), LDL-C and calculated sdLDL-C by Sampson’s equation. Methods: After exclusion of subjects with IHD or those with TG ≥ 800 mg/dL, a total of 18,176 subjects (men/women: 11,712/6,464, mean age: 46 years) were recruited among 28,990 Japanese individuals who received annual health checkups. Results: During the 10-year follow-up period, 456 men (3.9%) and 121 women (1.9%) newly developed IHD. Multivariable Cox proportional hazard analyses after adjustment of age, sex, obesity, smoking habit, family history of IHD, estimated glomerular filtration rate, hypertension and diabetes mellitus at baseline showed that the hazard ratio (HR) (1.38 [95% confidence interval: 1.03-1.85]) for new onset of IHD in subjects with the 4th quartile (Q4) of sdLDL-C (≥ 42 mg/dL) was significantly higher than that in subjects with the 1st quartile (Q1) (≤ 24 mg/dL) as the reference, though the adjusted HRs in subjects with Q2-Q4 of TC, HDL-C, non-HDL-C, LDL-C and TG were comparable with those in subjects with Q1 of the respective lipid fractions. The adjusted HR with a restricted cubic spline increased with a higher level of calculated sdLDL-C as a continuous value at baseline. Conclusions: sdLDL-C level calculated by Sampson’s equation is a predominant predictor for the development of IHD in a general Japanese population.

著者

Tatsuya SATO Taku SHIMOSAWA Yosuke HIMURA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Communications (ISSN:09168516)

巻号頁・発行日

vol.E105-B, no.11, pp.1318-1331, 2022-11-01

被引用文献数

3

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Enterprises have paid attention to consortium blockchains like Hyperledger Fabric, which is one of the most promising platforms, for efficient decentralized transactions without depending on any particular organization. A consortium blockchain-based system will be typically built across multiple organizations. In such blockchain-based systems, system operations across multiple organizations in a decentralized manner are essential to maintain the value of introducing consortium blockchains. Decentralized system operations have recently been becoming realistic with the evolution of consortium blockchains. For instance, the release of Hyperledger Fabric v2.x, in which individual operational tasks for a blockchain network, such as command execution of configuration change of channels (Fabric's sub-networks) and upgrade of chaincodes (Fabric's smart contracts), can be partially executed in a decentralized manner. However, the operations workflows also include the preceding procedure of pre-sharing, coordinating, and pre-agreeing the operational information (e.g., configuration parameters) among organizations, after which operation executions can be conducted, and this preceding procedure relies on costly manual tasks. To realize efficient decentralized operations workflows for consortium blockchain-based systems in general, we propose a decentralized inter-organizational operations method that we call Operations Smart Contract (OpsSC), which defines an operations workflow as a smart contract. Furthermore, we design and implement OpsSC for blockchain network operations with Hyperledger Fabric v2.x. This paper presents OpsSC for operating channels and chaincodes, which are essential for managing the blockchain networks, through clarifying detailed workflows of those operations. A cost evaluation based on an estimation model shows that the total operational cost for executing a typical operational scenario to add an organization to a blockchain network having ten organizations could be reduced by 54 percent compared with a conventional script-based method. The implementation of OpsSC has been open-sourced and registered as one of Hyperledger Labs projects, which hosts experimental projects approved by Hyperledger.