- 著者
- Hiroki UCHIKAWA Taichi KIN Satoshi KOIZUMI Katsuya SATO Tatsuya UCHIDA Yasuhiro TAKEDA Tsukasa KOIKE Satoshi KIYOFUJI Shigeo YAMASHIRO Akitake MUKASA Nobuhito SAITO
- 出版者
- The Japan Neurosurgical Society
- 雑誌
- Neurologia medico-chirurgica (ISSN:04708105)
- 巻号頁・発行日
- pp.2023-0003, (Released:2023-08-23)
- 参考文献数
- 30
Rebleeding from a ruptured intracranial aneurysm has poor outcomes. Although numerous factors are associated with rebleeding, studies on computational fluid dynamics (CFD) on hemodynamic parameters associated with early rebleeding are scarce. In particular, no report of rebleeding in ultra-early phase exists. We aimed to elucidate the specific hemodynamic parameters associated with ultra-early rebleeding using CFD. In this study, the rebleeding group included patients with aneurysmal subarachnoid hemorrhage (aSAH) that rebled within 6 h from the onset. The control group included patients without rebleeding, observed for >10 h following the initial rupture. Clinical images after initial rupture and before rebleeding were used to build 3D vessel models for hemodynamic analysis focusing on the following parameters: time-averaged wall shear stress (WSS), normalized WSS, low shear area, oscillatory shear index, relative residence time, pressure loss coefficient, and aneurysmal inflow rate coefficient (AIRC). Five and 15 patients in the rebleeding and control groups, respectively, met the inclusion criteria. The World Federation of Neurosurgical Surgeons grade was significantly higher in the rebleeding group (p = 0.0088). Hemodynamic analysis showed significantly higher AIRC in the rebleeding group (p = 0.042). The other parameters were not significantly different between groups. There were no significant differences or correlations between SAH severity and AIRC. AIRC was identified as a hemodynamic parameter associated with ultra-early rebleeding of ruptured intracranial aneurysms. Thus, AIRC calculation may enable the prediction of ultra-early rebleeding.
- 著者
- Ryo Irie Tatsuya Uchida Kazuhiro Matsumoto
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- pp.150747, (Released:2015-08-21)
- 被引用文献数
- 25
The late Emeritus Professor Tsutomu Katsuki, who was leading the field of catalytic asymmetric oxidation worldwide, suddenly passed away on October 30, 2014. Here we wish to commemorate him by highlighting his representative research works particularly on his unique catalytic systems for asymmetric alkene epoxidation, sulfoxidation, alcohol oxidation, oxidative coupling reactions with a personal view and memory.