- 著者
- Shinichi Goto Noriko Tamura Kengo Ayabe Eri Kato Terumitsu Hasebe Shu Takagi Yota Kawamura Shinya Goto
- 出版者
- JAPANESE SOCIETY OF BIORHEOLOGY
- 雑誌
- Journal of Biorheology (ISSN:18670466)
- 巻号頁・発行日
- vol.31, no.2, pp.30-34, 2017 (Released:2018-02-23)
- 参考文献数
- 19
- 被引用文献数
- 4 4
Formation of thrombi is a complex biological event involving platelets and coagulation cascades. The both have been well investigated individually. However, the inter-relationship between them is still to be elucidated. The recent progresses in computer technology may allow us to simulate complex biological phenomena in silico. Here we report a novel method to reproduce the complex system of the inter-relationship between platelet and coagulation by combining the previous simulation model of platelet adhesion with the model of coagulation cascade. We have reproduced the biological process of thrombus growth occurring in the mice cremasteric artery induced by endothelial injury by FeCl3 with our newly developed computer simulator.