- 著者
- Shinichi Goto Noriko Tamura Kengo Ayabe Eri Kato Terumitsu Hasebe Shu Takagi Yota Kawamura Shinya Goto
- 出版者
- JAPANESE SOCIETY OF BIORHEOLOGY
- 雑誌
- Journal of Biorheology (ISSN:18670466)
- 巻号頁・発行日
- vol.31, no.2, pp.30-34, 2017 (Released:2018-02-23)
- 参考文献数
- 19
- 被引用文献数
- 4 4
Formation of thrombi is a complex biological event involving platelets and coagulation cascades. The both have been well investigated individually. However, the inter-relationship between them is still to be elucidated. The recent progresses in computer technology may allow us to simulate complex biological phenomena in silico. Here we report a novel method to reproduce the complex system of the inter-relationship between platelet and coagulation by combining the previous simulation model of platelet adhesion with the model of coagulation cascade. We have reproduced the biological process of thrombus growth occurring in the mice cremasteric artery induced by endothelial injury by FeCl3 with our newly developed computer simulator.
- 著者
- Yoshihiro Morino Seiji Tamiya Naoki Masuda Yota Kawamura Masakazu Nagaoka Takashi Matsukage Nobuhiko Ogata Gaku Nakazawa Teruhisa Tanabe Yuji Ikari
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.1006040751, (Released:2010-06-09)
- 参考文献数
- 23
- 被引用文献数
- 26 47
Background: Several studies have indicated that the clinical outcomes of sirolimus-eluting stents (SES) are significantly associated with longitudinal positioning of the stent relative to the underlying plaque distribution. Methods and Results: Optimal SES landing was determined using unique stepwise intravascular ultrasound (IVUS) criteria, mainly targeting the sites with plaque burden <50% (plaque area/external elastic membrane area ×100). To verify the criteria, (1) achievability and (2) actual impact on clinical and angiographic outcomes were assessed. A total of 162 consecutive patients with 180 lesions were enrolled and treated according to the IVUS criteria. Plaque burden at the proximal and distal margins was 41.4±13.6% (n=144) and 34.9±15.6% (n=170), respectively (within 3 mm of stent ends). The target was achieved in 72.3% of the proximal and 84.1% of the distal margin for the criteria. A strikingly low angiographic margin re-stenosis rate (2.7% of proximal and 1.4% of distal margin) and low target lesion revascularization rate (2.2%) were achieved. Receiver operator characteristic curve indicated that plaque burden was the strongest predictor of margin re-stenosis and its threshold (51.6%) was almost identical to that of the criteria. Conclusions: The proposed stepwise IVUS criteria mainly targeting plaque burden <50% are feasible and useful in the real-world practice of SES implantation.