著者

Kazumasa Fujita Shota Kajiyama Hiroo Noguchi Takeshi Arita

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.1, pp.31-37, 2022 (Released:2022-07-29)

参考文献数

27

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Atrial fibrillation (AF) is one of the most prevalent arrythmias worldwide and associated with an increased risk of stroke and systemic thromboembolism. Stroke prevention with direct oral anticoagulation (DOAC) is recommended in patients with non-valvular AF (NVAF) at high risk of stroke. WATCHMANTM percutaneous left atrial appendage closure (LAAC) device is currently introduced as an alternative to DOAC for patients with NVAF ineligible for long-term administration of DOAC due to high risk of bleeding. This review article may contribute to recognize the paradigm shift in which stroke prevention should be carried out topically but not systemically, because left atrial appendage (LAA) is the main source of thrombus formation in AF patients. In addition, this review article introduces the current knowledge and future perspective of LAAC strategy and technology.

著者

Keiko Fujii Haruko Onodera Chihiro Teraguchi Akiko Ohsuga Atsuko Takahashi

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.35, no.1, pp.18-28, 2021 (Released:2021-03-30)

参考文献数

39

被引用文献数

1

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In this study, we aimed to elucidate the optimal conditions for baking gluten-free rice bread while considering the powder characteristics of 10 rice flour varieties by optimizing the quantity of water to be added and examining the effects of particle size, protein content, amylose content, and degree of starch damage in rice flour.Rice breads were prepared with varying quantities of water, and the range of quantity of water that allowed baking varied depending on the variety of rice flour used. We determined that high protein content in rice flour allowed a wide range of quantity of water that can be added to be suitable for bread baking; however, concurrent with this are that the compressive stress of the bread increases as well. Moreover, we examined the effect of ingredient composition on the optimal quantity of water added to ensure the swelling of the rice flour bread and found that the quantity of water that can be added ranged from 15- to 17-fold when the quantity of water to be added was based on the protein content in rice flour. These results indicate that when preparing gluten-free rice bread with a large specific volume, the quantity of water to be added can be determined using the protein content in rice flour as an indicator. Additionally, we found that when the protein content in rice flour is not known, the quantity of water to be added can be adjusted to achieve 10 to 20 Pa loss modulus G’’ of the batter.

著者

Ryoko Shimada Miki Yoshimura

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.35, no.1, pp.10-17, 2021 (Released:2021-03-30)

参考文献数

22

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Resistant starch (RS) displays physiological properties similar to that of dietary fiber. In this study, the physical properties and palatability of bread made with RS type 4 (RS-4, chemically modified starch) were evaluated. Distarch phosphate potato starch, distarch phosphate rice starch, distarch phosphate tapioca starch, phosphated distarch phosphate sweet potato starch, and phosphated distarch phosphate wheat starch were the sources. Wheat flour was replaced with 20% (w/w) RS-4, and the bread was thereby considered as RS-4 added bread. Bread without RS-4 was the control bread. RS-4 added loaves of bread had less specific volume than the control bread. The hardness of RS-4 added bread samples was also higher than that of the control bread. It was observed using a scanning electron microscope (SEM) that RS-4 was not gelatinized in bread. However, RS-4 added bread samples obtained overall acceptability comparable to that of the control bread in the sensory evaluation. It was concluded that differences in the sizes of starch particles added to the bread did not affect palatability. The RS-4 bread with potatoes starch appeared to cause the hardness of the crumb during baking; suggesting that RS-4 derived from cereals would be more suitable for use in bread.

著者

Masamitsu Nakayama Shinichi Goto Shinya Goto

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.2, pp.68-75, 2022 (Released:2022-10-25)

参考文献数

42

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A1 domain of von Willebrand factor (VWF) binding with platelet glycoprotein (GP) Ibα play crucial roles in platelet adhesion and subsequent passive shape changes in the platelets such as pseudopod formation under high wall shear rate conditions. However, the effects of specific inhibitors of VWF binding with GPIbα on the length of pseudopods supporting platelet adhesion on VWF are still to be elucidated. Here we measured the length of pseudopods in the presence of VWF-GPIbα inhibitor of caplacizumab. The length of pseudopods was 6.5 ± 0.2 μm (mean ± 95% confidential interval [CI]) and 6.9 ± 0.2 μm (mean ± 95% CI) at 100 and 200 nM of caplacizumab concentrations and was longer than those formed in its absence (5.2 ± 0.2 μm, p < 0.05). Our experiments also revealed that the surface area coverage by platelets in the presence of caplacizumab at a concentration of 200 nM of 26.1 ± 6.4% after 60-second blood perfusion was smaller than its absence (45.2 ± 7.5%, p < 0.05). Our results suggest that fewer numbers of VWF-GPIbα bonds generating larger binding force with a longer length of pseudopods, support the platelet adhesion on VWF in the presence of caplacizumab at a wall shear rate of 1,500 s–1.

著者

Masahito Hitosugi Masashi Ikeda Xia Zhu Hisayoshi Kato Kazunobu Omura Toshiaki Nagai Shogo Tokudome

出版者

Japanese Society of Biorheology

雑誌

日本バイオレオロジー学会誌 (ISSN:09134778)

巻号頁・発行日

vol.21, no.1, pp.35-40, 2007-03-25 (Released:2012-09-24)

参考文献数

12

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We compared the anticoagulant and fibrinolytic effects of the major functional food products generated by Bacillus subtilis natto. We analyzed NSK-SDR and NKCPR powders that consist mainly of nattokinase and bacillopeptidase F, respectively. The specific activity of the plasmin-like activity of NKCPR H was about 2.5-fold higher than that of NSK-SDR. Although both NSK-SDR and NKCPR reduced fibrin monomer levels in human blood, the anticoagulant effect of NKCPR was over 100-fold higher than that of NSK-SDR. Dietary supplements with anticoagulant and fibrinolytic effects might play an important role in preventing thrombotic diseases.

著者

Makoto Ando Tomota Suminaka Noriaki Shimada Kenichiro Asano Jun-ichi Ono Kazuaki Jikuya Seiichi Mochizuki

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.32, no.2, pp.46-55, 2018 (Released:2018-12-22)

参考文献数

34

被引用文献数

4 4

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The ratio of the volumes of extracellular water to total body water (ECW/TBW) obtained by multi-frequency bioelectrical impedance analysis (MF-BIA) indicates body water balance. However, the characteristics of ECW/TBW in hemodialysis (HD) patients have not been fully investigated yet. We evaluated correlations of ECW/TBW with body composition, circulatory and body fluid status, and nutritional status in 60 stable maintenance HD patients using MF-BIA. ECW/TBW increased with increasing age and showed significant positive correlations with volume index (VI), cardiothoracic ratio, and brain natriuretic peptide, all of which are indices of circulatory and body fluid status. Furthermore, there were significant negative correlations between ECW/TBW and serum albumin (Alb), the geriatric nutritional risk index, and the normalized protein catabolic rate, all of which indicate nutritional status. Following multiple regression analysis, the independently related factors for total subjects were age, VI, and Alb. In obese HD patients, ECW/TBW tended to decrease, indicating intravascular dehydration. In conclusion, ECW/TBW in HD patients was shown to increase with age and can reflect circulatory, body fluid, and nutritional status, as well as the difference between predetermined dry weight and “optimal body weight” which may change along with a patient’s nutritional status.

著者

Gen Nakaji Maroka Shinchi Yurika Ohba Akihiro Koike

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.1, pp.23-30, 2022 (Released:2022-07-29)

参考文献数

19

被引用文献数

1

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Percutaneous coronary intervention (PCI) using balloon technology and stent implantation has revolutionized the interventional cardiology since the late 1970s. The plane old balloon angioplasty (POBA) was first proposed in the late 1970s as an alternative to coronary artery bypass grafting (CABG) for the treatment of coronary artery disease (CAD) such as angina pectoris and acute myocardial infarction (AMI). Thereafter, bare metal stent (BMS) was designed to overcome the problems proposed by POBA such as acute occlusion and restenosis of coronary target lesion. However, a new problem of BMS-induced in-stent restenosis (ISR) has appeared, and drug-eluting stent (DES) was introduced to resolve the problem of ISR. DES has improved the clinical outcome of patients undergoing PCI. Contemporary stent technology shows remarkable progress, and further effort continues to improve the design, structure, and materials of DES. However, DES has proposed a new problem of very late stent thrombosis. To overcome this late complication, non-stent strategy is introduced into the PCI. This article aims to review the historical development and future perspective of the PCI especially focusing on the evolution of DES.

著者

Eiji Karashima Masahiko Fujihara

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.1, pp.3-11, 2022 (Released:2022-07-29)

参考文献数

58

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Peripheral artery disease (PAD) is an obstructive arterial disease of the lower extremities. Due to the aging society and improved diagnostic techniques, the number of patients identified with PAD is increasing. Endovascular treatment (EVT) is a widely accepted interventional management method for diseased lower extremity arteries. Anatomically, the arteries of the lower extremities are divided into three segments: aortoiliac, femoropopliteal, and below-the-knee. The strategies of EVT recommended in the relevant guidelines are different for each segment. During the past 20 years, the indications and strategies of EVT have been evolving owing to the development of devices and improvement of clinical outcomes of EVT. Although it might be challenging to catch up with the evolving EVT strategies, we should develop an optimal EVT strategy for each PAD patient, considering that patient and lesion characteristics would also affect clinical outcomes. In this review, we describe the current knowledge of EVT strategies for each segment. We selected the EVT strategies that are currently performed for a majority of symptomatic PAD patients.

著者

Isamu Kaneda Toru Maruyama

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.1, pp.1-2, 2022 (Released:2022-07-29)

参考文献数

2

著者

Kazuko Hirao Tomoko Kondo Keiji Kainuma Setsuko Takahashi

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.35, no.1, pp.29-41, 2021 (Released:2021-03-30)

参考文献数

75

被引用文献数

3

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This paper reviews starch gel foods from the perspective of cookery science: warabi mochi (traditional sweet gel in Japan) and blancmange as hard gels and pastry cream/custard as a soft gel. Since warabi mochi is made from expensive warabi starch, physiochemical properties of several starches were tested as possible replacers. High potential of sago starch as a replacer was demonstrated as compared with sweet potato, potato, tapioca, and kudzu starches which are currently used as the replacers. Sago starch showed excellent characteristics in gel elasticity comparable to sweet potato and potato starches, high gel cohesiveness and low gel adhesiveness comparable to tapioca starch, and gel hardness comparable to kudzu starch. Toward quality improvements of warabi mochi, its preparation methods were also optimized. For instance, trehalose was added to suppress starch retrogradation in warabi mochi, and modified wheat starch was added to stabilize its gel quality. Meanwhile, warabi mochi is primarily a mixture of starches, sugars, and water, whereas most starch gel foods are mixtures of the primary ingredients and secondary ingredients such as proteins and fats. As for the blancmange, milk was replaced with soy protein isolate or soy milk powder for its quality improvement. For maximizing the physicochemical properties as well as taste, ratio of starch, protein, and fat was optimized by Scheffé’s simplex lattice design method: its triangular diagram clearly showed its optimal ratio for blancmange of high quality. Regarding pastry cream/custard, since its melting mouthfeel governs overall quality preference, methods to evaluate the melting mouthfeel were established. Thereafter, applicability of modified starches to pastry cream/custard was investigated to fit its texture to each food preparation. Based on physicochemical properties of the modified starches, pastry cream/custard preparation was adjusted to each of various food products.

著者

Isamu Kaneda Miki Yoshimura

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.35, no.1, pp.1, 2021 (Released:2021-03-30)

著者

Shinichi Goto Noriko Tamura Kengo Ayabe Eri Kato Terumitsu Hasebe Shu Takagi Yota Kawamura Shinya Goto

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.31, no.2, pp.30-34, 2017 (Released:2018-02-23)

参考文献数

19

被引用文献数

4 4

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Formation of thrombi is a complex biological event involving platelets and coagulation cascades. The both have been well investigated individually. However, the inter-relationship between them is still to be elucidated. The recent progresses in computer technology may allow us to simulate complex biological phenomena in silico. Here we report a novel method to reproduce the complex system of the inter-relationship between platelet and coagulation by combining the previous simulation model of platelet adhesion with the model of coagulation cascade. We have reproduced the biological process of thrombus growth occurring in the mice cremasteric artery induced by endothelial injury by FeCl3 with our newly developed computer simulator.

著者

Michinari Hieda Toru Maruyama

出版者

JAPANESE SOCIETY OF BIORHEOLOGY

雑誌

Journal of Biorheology (ISSN:18670466)

巻号頁・発行日

vol.36, no.1, pp.12-22, 2022 (Released:2022-07-29)

参考文献数

104

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Left ventricular assist device (LVAD) is an important therapeutic option for patients with end-stage advanced heart failure. LVAD can reduce cardiovascular death and improve the quality of life in patients with end-stage advanced heart failure. However, as LVAD-implanted patients increase and survival becomes prolonged, many patients experience serious complications. Major complications of LVAD include ischemic and hemorrhagic strokes, bleeding complications, device thrombosis, right heart failure, and LVAD related infections. These complications lead to worse mortality in patients with LVAD. In particular, cerebrovascular events and gastrointestinal bleeding are the most dreaded complications. High molecule weight multimers of von Willebrand factor (vWF-HMWM) play an essential role in platelet adhesion and aggregation, but high shear stress caused by LVAD pump diminishes the vWF-HMWM. In fact, in response to the shear stress of LVAD, vWF exposes cleavage domains of ADAMTS 13 to form smaller multimeric molecules. Therefore, in many patients with LVAD, the vWF reduces its large multimers and lowers the ability to bind sufficiently to platelets and sub-endothelial collagen, resulting in the acquired von Willebrand syndrome. Thus, in LVAD patients with acquired von Willebrand syndrome, vWF function is impaired, and this impairment is associated with hemocompatibility-related adverse events. Based on hemorheology, this review focuses on the pathophysiology of acquired von Willebrand syndrome and its management in patients with LVAD.