- 著者
- Tohru MATSUURA Yoshiaki HISHIMOTO Shozo SHIMAZAKI Masakazu OCHIAI Toshiaki KIRIYAMA Naoto ENDO Takashi HACHIYA Susumu ICHINOSE Toshitami SAWAYAMA Tsuguo SHIKATA Isao NIKI Susumu MARUMOTO
- 出版者
- International Heart Journal Association
- 雑誌
- Japanese Heart Journal (ISSN:00214868)
- 巻号頁・発行日
- vol.9, no.3, pp.247-257, 1968 (Released:2008-12-09)
- 参考文献数
- 17
- 被引用文献数
- 1 1
The thyroid murmur was analyzed in respect to the various characteristics of the murmur per se, the changing aspects in the diseased state as well as the process of the therapy, and finally the pathogenesis by angiography and cast preparations of the thyroid.1. The thyroid murmur was recorded in 37 out of 39 cases of hyperthyroidism and it was often continuous murmur with systolic accentuation. The murmur was best recorded at the isthmus of the gland, and the murmur over the right lobe was significantly louder in many cases. The reason of this localization was discussed, based on the anatomy of the vessels.2. The intensity and duration of the murmur were well correlated with the severity of the signs and symptoms in the individual case. Thus it is concluded that the routine phonography of the thyroid gland has an important diagnostic value in the assessment of the diseased state as well as the objective judgement of the treatment.3. Investigated by the angiography and cast preparations, the most probable origin of the thyroid murmur was mainly in the region of the arterio-venous and arterio-arterial anastomoses. The accessory importance of the other conditions, such as hyperkinetic state and the compression of the artery by the congestion of the gland, was also discussed.
- 著者
- Mahitab Elsayed Daisuke Kobayashi Toshio Kubota Naoya Matsunaga Ryusei Murata Yuko Yoshizawa Natsuki Watanabe Tohru Matsuura Yuya Tsurudome Takashi Ogino Shigehiro Ohdo Takao Shimazoe
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Biological and Pharmaceutical Bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.39, no.8, pp.1238-1246, 2016-08-01 (Released:2016-08-01)
- 参考文献数
- 64
- 被引用文献数
- 2 22
Bisphosphonates and statins are known to have antitumor activities against different types of cancer cell lines. In the present study, we investigated the antiproliferative effects of the combination of zoledronic acid (ZOL), a bisphophosphonate, and fluvastatin (FLU), a statin, in vitro on two types of human pancreatic cancer cell lines, Mia PaCa-2 and Suit-2. The pancreatic cancer cell lines were treated with ZOL and FLU both individually and in combination to evaluate their antiproliferative effects using WST-8 cell proliferation assay. In this study, we demonstrated a potent synergistic antiproliferative effect of both drugs when used in combination in both cell lines. Moreover, we studied the molecular mechanism behind this synergistic effect, which was inhibited by the addition of the mevalonate pathway products, farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP). Furthermore, we aimed to determine the effect of ZOL and FLU combination on RhoA and Ras guanosine 5′-triphosphate (GTP)-proteins. The combination induced a marked accumulation in RhoA and unprenylated Ras. GGPP and FPP reversed the increase in the amount of both proteins. These results indicated that the combination treatment impaired RhoA and Ras signaling pathway by the inhibition of geranylgeranylation and/or farnesylation. This study provides a potentially effective approach for the treatment of pancreatic cancer using a combination treatment of ZOL and FLU.