- 著者
- 今村 友美 高橋 志乃 大内 智恵子 境谷 友希 西村 典子 松井 理恵 安井 恵理子 堀江 登 Tomomi Imamura Shino Takahashi Chieko Ouchi Yuki Sakaiya Noriko Nishimura Rie Matsui Eriko Yasui Noboru Horie
- 雑誌
- 武庫川女子大学紀要. 自然科学編 (ISSN:09163123)
- 巻号頁・発行日
- vol.56, pp.89-94, 2009-03-31
This study is focused on overdose of vitamin E. In particular,we examined its influence on pregnancy using a laboratory animal. It showed no change of hemoglobin level and triglyceride level in blood by the difference of vitamin E dose. However,it showed that antioxygenation of the vitamin E was shown because the fall of TBARS value in the brain that was taken have much vitamin E intakes. The cause was not clear,the vitamin E intake of inappropriate quantity may cause pregnancy abnormality. Because, pregnancy abnormal ratios increased that growth insufficiency of the fetus was observed low group and high group in vitamin E. It suggested that the surplus intake of the vitamin E have possibilities to cause bad influence to pregnancy.
- 著者
- Yasushi Ohmachi Tomomi Imamura Mizuyo Ikeda Eriko Shishikura Eunjoo Kim Osamu Kurihara Kazuo Sakai
- 出版者
- JAPANESE SOCIETY OF TOXICOLOGIC PATHOLOGY
- 雑誌
- Journal of Toxicologic Pathology (ISSN:09149198)
- 巻号頁・発行日
- vol.28, no.2, pp.65-71, 2015 (Released:2015-05-28)
- 参考文献数
- 15
- 被引用文献数
- 15 21
To evaluate the effectiveness of sodium bicarbonate (SB) in removing uranium and protecting animals from uranium toxicity, we intramuscularly administered 1 mg/kg of uranyl nitrate to 8-wk-old male SD rats, and 20 min after administration of uranyl nitrate, the animals were given a single oral administration of SB at 0.1, 0.3 or 1 g/kg. The SB treatment at a dose of 0.3 g/kg or more raised the pH of the rats’ urine until 4 h after treatment, and it significantly reduced the uranium amounts in the kidneys at 1 day after treatment. In another experiment, rats were intramuscularly administered 1 mg/kg of uranyl nitrate, and 20 min later, the animals were treated with sodium bicarbonate (0.1 or 1 g/kg). The rats were autopsied at 1, 3 and 7 days after uranium treatment. High-dose SB resulted in a significant increase in urinary uranium excretion in the first 24 h and a reduction of uranium deposition in the kidneys and femurs, and it also significantly suppressed uranium-induced renal toxicity, as shown by both histopathology and clinical chemistry at 3 days after uranium treatment. Low-dose SB did not show such marked effects. Our findings demonstrated that the uranium decorporation effect of sodium bicarbonate was observed at the dosage showing urine alkalinization in rats and that decorporation effect of sodium bicarbonate might be beneficial if it is administered immediately after incorporation of soluble uranium.