著者

Tohru Sakai Emi Shuto Tomoyo Taki Honami Imamura Miku Kioka Akiko Nakamoto Seiji Mizoguchi Shouko Amano Yukari Kawano Mariko Nakamoto Rie Tsutumi Toshio Hosaka

出版者

The University of Tokushima Faculty of Medicine

雑誌

The Journal of Medical Investigation (ISSN:13431420)

巻号頁・発行日

vol.59, no.1,2, pp.95-101, 2012 (Released:2012-03-08)

参考文献数

16

被引用文献数

1

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NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)-immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice. J. Med. Invest. 59: 95-101, February, 2012

著者

Tohru Sakai Miyuki Ohhata Misaki Fujii Sayaka Oda Yasuna Kusaka Miki Matsumoto Akiko Nakamoto Tomoyo Taki Mariko Nakamoto Emi Shuto

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.40, no.4, pp.391-395, 2017-04-01 (Released:2017-04-01)

参考文献数

27

被引用文献数

16

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Propolis is a bee product with various biological properties. C57BL/6 mice were fed a high-fat diet and treated with propolis for 14 weeks. Body weight in mice treated with 2% propolis was less than that in control mice from 3 weeks after the start of treatment until 14 weeks except for the 7th week. Mice treated with propolis showed significantly lower epididymal fat weight and subcutaneous fat weight. Infiltration of epididymal fat by macrophages and T cells was reduced in the propolis group. Supplementation of propolis increased feces weight and fat content in feces, suggesting that mechanisms of weight reduction by propolis partly include a laxative effect and inhibition of fat absorption.