著者

Makiko Takenaka Noriko Miyake Toshiyuki Kimura Setsuko Todoriki Tetsuo Urushiyama

出版者

Japanese Society for Food Science and Technology

雑誌

Food Science and Technology Research (ISSN:13446606)

巻号頁・発行日

vol.28, no.3, pp.245-255, 2022 (Released:2022-05-20)

参考文献数

16

被引用文献数

2

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This study aimed to find an effective protocol as a cooking pre-treatment for the petioles and young spikes of Petasites japonicus to reduce their contents of pyrrolizidine alkaloids (PAs), a type of natural toxin in plants such as the Asteraceae and Boraginaceae families. After determining the most common cooking pre-treatment methods for petioles and young spikes of Petasites japonicus from a survey of recipes, various treatments were examined for their effectiveness at reducing PAs. It was concluded that both boiling and soaking processes were important for the reduction of PAs in pre-treatment of cooking the petioles and the young spikes of Petasites japonicus, and that a longer soaking time had a greater effect in reducing PAs. PAs in the petioles and young spikes decreased to less than 50% of the original amount in 1 h and 6 h, respectively during soaking after boiling (and peeling).

著者

Kensaku Nishihira Nehiro Kuriyama Kosuke Kadooka Yasuhiro Honda Keisuke Yamamoto Shun Nishino Suguru Ebihara Kenji Ogata Toshiyuki Kimura Hiroshi Koiwaya Yoshisato Shibata

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.10, pp.474-481, 2022-10-07 (Released:2022-10-07)

参考文献数

30

被引用文献数

1

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Background: As life expectancy rises, percutaneous coronary intervention (PCI) is being performed more frequently, even in elderly patients with acute myocardial infarction (AMI). This study evaluated outcomes of elderly patients with AMI complicated by heart failure (AMIHF), as defined by Killip Class ≥2 at admission, who undergo PCI.Methods and Results: We retrospectively analyzed 185 patients with AMIHF aged ≥80 years (median age 85 years) who underwent PCI between 2009 and 2019. The median follow-up period was 572 days. The rates of in-hospital major bleeding (Bleeding Academic Research Consortium Type 3 or 5) and in-hospital all-cause mortality were 20.5% and 25.9%, respectively. The proportion of frail patients increased during hospitalization, from 40.6% at admission to 59.2% at discharge (P<0.01). The cumulative incidence of all-cause mortality was 36.3% at 1 year and 44.1% at 2 years. After adjusting for confounders, advanced age, Killip Class 4, final Thrombolysis in Myocardial Infarction flow grade <3, and longer door-to-balloon time were associated with higher mortality, whereas higher left ventricular ejection fraction and cardiac rehabilitation were associated with lower mortality (all P<0.05). Progression of frailty during hospitalization was an independent risk factor for long-term mortality in hospital survivors (P<0.01).Conclusions: The management of patients with AMIHF aged ≥80 years who undergo PCI remains challenging, with high rates of in-hospital major bleeding, frailty progression, and mortality.