- 著者
- Yen-Ting Yeh Jung-Chung Hsu Pen-Chih Liao Ai-Hsien Li Yuan-Hung Liu Kuo-Chin Chen Wenpo Chuang Shin-Rong Ke Yu-Wei Chiu Yen-Wen Wu
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.85, no.2, pp.166-174, 2021-01-25 (Released:2021-01-25)
- 参考文献数
- 21
Background:Studies investigating the modulators of mortality benefit conferred by peri-angioplasty glycoprotein IIb/IIIa inhibitors in ST-elevation myocardial infarction (STEMI) are still lacking.Methods and Results:A prospective database (n=1,025) of consecutive cases undergoing primary percutaneous coronary intervention for STEMI was retrospectively analyzed. For patients in Killip class I, II or III, IV, the multivariate-adjusted hazard ratios of 30-day all-cause mortality associated with adjunctive tirofiban were 3.873 (95% CI 0.504–29.745; P=0.193), 0.550 (95% CI 0.188–1.609; P=0.275), and 0.264 (95% CI 0.099–0.704; P=0.008), respectively. The P value for a linear trend was 0.032. Patients who had a body mass index (BMI) within 22.9–25.0 kg/m2had a significant benefit from tirofiban (adjusted HR 0.344; 95% CI 0.145–0.814; P=0.015) compared to other BMI groups. The P value for a quadratic trend was 0.012. A novel Killip−BMI score (KBS = 2.5 × Killip category − | BMI − 24 |) was calculated to select the beneficial population. A KBS ≥2 was associated with significant mortality benefit, whereas a KBS <0 predicted increased 30-day mortality with tirofiban use.Conclusions:Survival benefit from peri-angioplasty tirofiban therapy for STEMI was positively correlated with the Killip class. Tirofiban should be used cautiously in either underweight or overweight patients. The novel KBS used in this study can guide peri-angioplasty use of adjunctive tirofiban in patients with STEMI undergoing primary angioplasty.
- 著者
- Wentao ZHANG Chen MIAO Wen WU
- 出版者
- The Institute of Electronics, Information and Communication Engineers
- 雑誌
- IEICE TRANSACTIONS on Communications (ISSN:09168516)
- 巻号頁・発行日
- vol.E106-B, no.4, pp.307-316, 2023-04-01
Direction of arrival (DOA) estimation has been a primary focus of research for many years. Research on DOA estimation continues to be immensely popular in the fields of the internet of things, radar, and smart driving. In this paper, a simple new two-dimensional DOA framework is proposed in which a triangular array is used to receive wideband linear frequency modulated continuous wave signals. The mixed echo signals from various targets are separated into a series of single-tone signals. The unwrapping algorithm is applied to the phase difference function of the single-tone signals. By using the least-squares method to fit the unwrapped phase difference function, the DOA information of each target is obtained. Theoretical analysis and simulation demonstrate that the framework has the following advantages. Unlike traditional phase goniometry, the framework can resolve the trade-off between antenna spacing and goniometric accuracy. The number of detected targets is not limited by the number of antennas. Moreover, the framework can obtain highly accurate DOA estimation results.