文献一覧: YAMAGUCHI Kaori (著者)

5 0 0 0 IR The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts

著者: Yamasaki Chisato Murakami Katsuhiko Fujii Yasuyuki Sato Yoshiharu Harada Erimi Takeda Jun-ichi Taniya Takayuki Satake Ryuichi Kikugawa Shingo Shimada Makoto Tanino Motohiko Halligan Brian Shimoyama Mary Twigger Simon Yura Kei Kimura Kouichi Yasuda Tomohiro Nishikawa Tetsuo Akiyama Yutaka Motono Chie Mukai Yuri Shionyu Masafumi Nagasaki Hideki Suwa Makiko Horton Paul Kikuno Reiko Ohara Osamu Lancet Doron Eveno Eric Graudens Esther Imbeaud Sandrine Debily Marie Anne Jia Libin Hayashizaki Yoshihide Amid Clara Han Michael Osanger Andreas Endo Toshinori Thomas Michael A. Hirakawa Mika Makalowski Wojciech Nakao Mitsuteru Kim Nam-Soon Thierry-Mieg Danielle Yoo Hyang-Sook De Souza Sandro J. Bonaldo Maria de Fatima Niimura Yoshihito Kuryshev Vladimir Schupp Ingo Wiemann Stefan Bellgard Matthew Thierry-Mieg Jean Wagner Lukas Zhang Qinghua Go Mitiko Minoshima Shinsei Ohtsubo Masafumi Hanada Kousuke Koyanagi Kanako O. Tonellato Peter Isogai Takao Zhang Ji Lenhard Boris Kim Sangsoo Chen Zhu Hinz Ursula Estreicher Anne Nakai Kenta Makalowska Izabela Barrero Roberto A. Hide Winston Tiffin Nicola Wilming Laurens Chakraborty Ranajit Soares Marcelo Bento Chiusano Maria Luisa Suzuki Yutaka Auffray Charles Yamaguchi-Kabata Yumi Itoh Takeshi Gough Craig Hishiki Teruyoshi Fukuchi Satoshi Nishikawa Ken Sugano Sumio Nomura Nobuo Tateno Yoshio Imanishi Tadashi Gojobori Takashi Chun Hong-Woo Habara Takuya Hanaoka Hideki Hayakawa Yosuke Hilton Philip B. Kaneko Yayoi Kanno Masako Kawahara Yoshihiro Kawamura Toshiyuki Matsuya Akihiro Nagata Naoki Nishikata Kensaku Ogura Noda Akiko Nurimoto Shin Saichi Naomi Sakai Hiroaki Sanbonmatsu Ryoko Shiba Rie Suzuki Mami Takabayashi Kazuhiko Takahashi Aiko Tamura Takuro Tanaka Masayuki Tanaka Susumu Todokoro Fusano Yamaguchi Kaori Yamamoto Naoyuki Okido Toshihisa Mashima Jun Hashizume Aki Jin Lihua Lee Kyung-Bum Lin Yi-Chueh Nozaki Asami Sakai Katsunaga Tada Masahito Miyazaki Satoru Makino Takashi Ohyanagi Hajime Osato Naoki Tanaka Nobuhiko Suzuki Yoshiyuki Ikeo Kazuho Saitou Naruya Sugawara Hideaki O'Donovan Claire Kulikova Tamara Whitfield Eleanor
出版者: Oxford University Press
雑誌: Nucleic Acids Research (ISSN:03051048)
巻号頁・発行日: vol.36, no.1, pp.D793-D799, 2008-01
被引用文献数: 12

Here we report the new features and improvements in our latest release of the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/), a comprehensive annotation resource for human genes and transcripts. H-InvDB, originally developed as an integrated database of the human transcriptome based on extensive annotation of large sets of full-length cDNA (FLcDNA) clones, now provides annotation for 120 558 human mRNAs extracted from the International Nucleotide Sequence Databases (INSD), in addition to 54 978 human FLcDNAs, in the latest release H-InvDB_4.6. We mapped those human transcripts onto the human genome sequences (NCBI build 36.1) and determined 34 699 human gene clusters, which could define 34 057 (98.1%) protein-coding and 642 (1.9%) non-protein-coding loci; 858 (2.5%) transcribed loci overlapped with predicted pseudogenes. For all these transcripts and genes, we provide comprehensive annotation including gene structures, gene functions, alternative splicing variants, functional non-protein-coding RNAs, functional domains, predicted sub cellular localizations, metabolic pathways, predictions of protein 3D structure, mapping of SNPs and microsatellite repeat motifs, co-localization with orphan diseases, gene expression profiles, orthologous genes, protein–protein interactions (PPI) and annotation for gene families. The current H-InvDB annotation resources consist of two main views: Transcript view and Locus view and eight sub-databases: the DiseaseInfo Viewer, H-ANGEL, the Clustering Viewer, G-integra, the TOPO Viewer, Evola, the PPI view and the Gene family/group.

2018-06-13 07:30:14
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1 0 0 0 OA Critical Level of Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction

著者: Koike Akira Hoshimoto Masayo Tajima Akihiko Nagayama Osamu Yamaguchi Kaori Goda Ayumi Yamashita Takeshi Sagara Koichi Itoh Haruki Aizawa Tadanori
出版者: 社団法人日本循環器学会
雑誌: Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)
巻号頁・発行日: vol.70, no.11, pp.1457-1461, 2006-10-20
被引用文献数: 6 20

Background In a recent study the indexes of cerebral oxygenation decreased during maximal exercise in nearly half of all patients with left ventricular dysfunction. Whether these levels decrease severely enough to influence mental status or level of consciousness was evaluated in the present study. Methods and Results Forty-two patients with idiopathic dilated cardiomyopathy (IDC) and 29 healthy subjects underwent a symptom-limited maximal exercise test. The cerebral oxyhemoglobin (O_2Hb) and tissue oxygenation index (TOI) were continuously monitored using near-infrared spectroscopy. The changes in O_2Hb and TOI were also measured in 7 subjects: 2 who experienced episodes of reduced consciousness caused by sudden decreases in blood pressure during exercise recovery and 5 who exhibited sustained ventricular tachycardia during an electrophysiological study. The change in cerebral O_2Hb during exercise in patients with IDC averaged 0.38±3.39μmol/L, significantly lower than in the normal subjects (4.30±4.47μmol/L, p<0.0001). The cerebral O_2Hb decreased during exercise in 18 of 42 patients with IDC. The change in cerebral TOI in the IDC patients during exercise was significantly less than that in the normal subjects (-2.0±4.7 vs 2.1±5.8%, p=0.002). The mean decreases in cerebral O_2Hb and TOI were -5.34μmol/L and -9.7%, respectively, in the patients with reduced consciousness during exercise recovery, and -2.52μmol/L and -16.5%, respectively, in those with ventricular tachycardia. Conclusion The indexes of cerebral oxygenation may drop severely enough during maximal exercise in some patients with severe IDC that consciousness is affected.

2009-11-10 12:45:09
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1 0 0 0 Effects of Supplemental O2 Inhalation on Cerebral Oxygenation During Exercise in Patients With Left Ventricular Dysfunction

著者: KOIKE Akira NAGAYAMA Osamu GODA Ayumi HOSHIMOTO Masayo YAMAGUCHI Kaori TAJIMA Akihiko UEJIMA Tokuhisa ITOH Haruki AIZAWA Tadanori
出版者: 社団法人日本循環器学会
雑誌: Circulation journal : official journal of the Japanese Circulation Society (ISSN:13469843)
巻号頁・発行日: vol.71, no.9, pp.1418-1423, 2007-08-20
被引用文献数: 1 5

Background It has been recently reported that cerebral oxyhemoglobin (O2Hb) decreases during exercise in nearly 50% of patients with dilated cardiomyopathy. The present study evaluated whether the inhalation of supplemental O2 diminishes the decrease in cerebral O2Hb during exercise. Methods and Results Ten patients with a left ventricular ejection fraction <50% and a clearly observable decrease in cerebral O2Hb during preliminary exercise testing underwent 2 additional symptom-limited incremental exercise tests: 1 while breathing room air (control) and the other while breathing 50% O2. In the latter test, the switch from room air to 50% O2 was performed, on average, at 43.0±14.2 W. Cerebral O2Hb was continuously monitored during exercise using near-infrared spectroscopy. In the control exercise test, cerebral O2Hb gradually decreased as the work rate increased in all the subjects. When the subjects breathed 50% O2, this decrease in cerebral O2Hb was diminished. The change in cerebral O2Hb from rest to peak exercise during the test under 50% O2 was significantly higher than that during the control test (-0.23 ±1.89 vs -2.47±1.57 μmol/L, p=0.002). Similarly, the change in the cerebral tissue oxygenation index was significantly higher in the test under 50% O2 (0.45 ±4.46 vs -3.33±3.06%, p=0.023). Conclusions Impaired cerebral oxygenation during moderate to heavy intensity exercise in patients with left ventricular dysfunction can be offset by breathing supplemental O2. (Circ J 2007; 71: 1418 - 1423)

2009-11-08 20:45:09
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