著者

YOUKICHI OHNO SHOETSU CHIBA SEISAKU UCHIGASAKI EIKOH UCHIMA HAJIME NAGAMORI MICHINAO MIZUGAKI YOSHIHARU OHYAMA KATSUHIKO KIMURA YASUO SUZUKI

出版者

Tohoku University Medical Press

雑誌

The Tohoku Journal of Experimental Medicine (ISSN:00408727)

巻号頁・発行日

vol.167, no.2, pp.155-158, 1992 (Released:2006-08-31)

参考文献数

3

被引用文献数

9 11

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OHNO, Y., CHIBA, S., UCHIGASAKI, S., UCHIMA, E., NAGAMORI, H., MIZUGAKI, M., OHYAMA, Y., KIMURA, K. and SUZUKI, Y. The Influence of Tetrodotoxin on the Toxic Effects of Aconitine in vivo. Tohoku J. Exp. Med., 1992, 167 (2), 155-158 -Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case. In order to elucidate the in vivo influence of TTX on the toxic effects of aconitine, a mixture of aconitine and TTX was administered to male ICR mice orally or intraperitoneally. The animal experiments revealed that the time of death due to aconitine was significantly delayed in proportion to the dose of TTX compared with the case for aconitine alone, and that the mortality of aconitine was lowered by TTX when the dose ratio of the two toxins was in a particular range. Accordingly, it is thought that the toxic effects of aconitine are attenuated by TTX in vivo.

著者

Keiko Hirakawa Kaoru Koike Yoshimasa Kanawaku Tsuyoshi Moriyama Norio Sato Takao Suzuki Kenichi Furihata Youkichi Ohno

出版者

Japan Oil Chemists' Society

雑誌

Journal of Oleo Science (ISSN:13458957)

巻号頁・発行日

pp.ess18212, (Released:2019-03-13)

被引用文献数

6

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Proton nuclear magnetic resonance (NMR) is useful for the analysis of biological samples such as serum. Free induction decays (FIDs) are NMR signals that follow a radio-frequency pulse applied at the resonance frequency. Short-time Fourier transform (STFT) is a basic method for time-frequency analyses. The purpose of this study was to ascertain whether the STFT of FIDs enables the sensitive detection of changes and differences in serum properties. FIDs were obtained from serum collected from young, healthy, male volunteers ≤ 40 years of age and seniors ≥ 65 years of age. Temporal changes in the instantaneous amplitudes for the time-domain analysis, fast Fourier transform for frequency-domain analysis, and STFT were applied to the FIDs. The STFT-based spectrogram represented the complex frequency components that changed dynamically over time, indicating that the spectrogram enabled the visualization of the features of an FID. Furthermore, the results of a partial least-squares discriminant analysis demonstrated that the STFT was superior to the other two methods for discriminating between serum from younger and older subjects. In conclusion, the STFT of FIDs obtained from proton NMR measurements was useful for evaluating similarities and dissimilarities in the FIDs obtained from serum samples.