著者
YOUKICHI OHNO SHOETSU CHIBA SEISAKU UCHIGASAKI EIKOH UCHIMA HAJIME NAGAMORI MICHINAO MIZUGAKI YOSHIHARU OHYAMA KATSUHIKO KIMURA YASUO SUZUKI
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.167, no.2, pp.155-158, 1992 (Released:2006-08-31)
参考文献数
3
被引用文献数
9 9

OHNO, Y., CHIBA, S., UCHIGASAKI, S., UCHIMA, E., NAGAMORI, H., MIZUGAKI, M., OHYAMA, Y., KIMURA, K. and SUZUKI, Y. The Influence of Tetrodotoxin on the Toxic Effects of Aconitine in vivo. Tohoku J. Exp. Med., 1992, 167 (2), 155-158 -Both aconite toxins (aconitine, mesaconitine, and hypaconitine) and a pufferfish toxin (tetrodotoxin, TTX) were detected in the blood of a legal autopsy case. In order to elucidate the in vivo influence of TTX on the toxic effects of aconitine, a mixture of aconitine and TTX was administered to male ICR mice orally or intraperitoneally. The animal experiments revealed that the time of death due to aconitine was significantly delayed in proportion to the dose of TTX compared with the case for aconitine alone, and that the mortality of aconitine was lowered by TTX when the dose ratio of the two toxins was in a particular range. Accordingly, it is thought that the toxic effects of aconitine are attenuated by TTX in vivo.

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There is a reported case of a woman poisoned by her husband with both aconite and tetrodotoxin, delaying her death… https://t.co/bXzAW64yoB
この事件がきっかけと思われる論文にvivioでのテトロドトキシンのアコニチン(トリカブトの毒)への影響の報告例がないと書かれててまじかとなった。 > However, there are no reports on the in… https://t.co/dRmC8pQnTk
1 1 https://t.co/B1E8b7vlPl
トリカブト毒の即効性をフグ毒による拮抗作用で遅らせることによってアリバイを成立させた殺人事件。検死したお医者さんの推理により逆転判決。お医者による検証内容も論文化されてる。 https://t.co/I9m88XjLdq https://t.co/XxnFDacZFZ

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