著者

YUKA HONDA MITSUYOSHI SUZUKI YUICHI SATO KEIJI KURODA HIROMICHI SHOJI TOSHIAKI SHIMIZU

出版者

The Juntendo Medical Society

雑誌

順天堂醫事雑誌 (ISSN:21879737)

巻号頁・発行日

vol.62, no.2, pp.153-159, 2016 (Released:2016-07-02)

参考文献数

30

被引用文献数

1

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Objective: The aim of this study was to investigate the associations of anti-Müllerian hormone (AMH) levels with physique and 25-hydroxyvitamin D (25OH-D) levels in healthy women of reproductive age based on measurements of nutritional status and physical constitution.Materials and Methods: Subjects comprised 108 non-obese women (age range, 21-39 years) who underwent examination of their physique, blood biochemistry and nutritional state. For data analysis, subjects were first divided by age. AMH levels were grouped by serum 25OH-D concentration using Holick’s classification: deficiency, <30 ng/ml; and sufficiency, ≥30 ng/ml.Results: Mean levels were 25.2±8.4 ng/ml for serum 25OH-D and 4.9±2.4 ng/ml for AMH. Overall, 76 women (70.4%) were diagnosed with 25OH-D deficiency. Serum AMH levels were significantly lower in subjects with 25OH-D deficiency (4.5±2.5 ng/ml) than in those with 25OH-D sufficiency (5.7±1.9 ng/ml; p<0.01). Significant differences were seen in the frequency of subjects with 25OH-D deficiency and sufficiency between low AMH (<2.2 ng/ml) status and normal AMH (≥2.2 ng/ml)(16/17 [94.1%] vs. 1/17 [5.9%] for low AMH status; 60/91 [65.9%] vs.31/91 [34.1%] for normal AMH status, respectively; p<0.05). Independent predictors of serum AMH levels≥2.2 ng/ml were serum 25OH-D level (p<0.05) and age (p<0.05) according to binary logistic regression analysis.Conclusions: Decreased serum AMH level is associated with vitamin D deficiency, but is unrelated to physique state in this population.