- 著者
- Asako Tsunemi Toyoyoshi Uchida Keiji Kuroda Yuko Ikemoto Asako Ochiai Hiromasa Goto Rikikazu Sugiyama Hiroaki Satoh Atsuo Itakura Hirotaka Watada
- 出版者
- The Japan Endocrine Society
- 雑誌
- Endocrine Journal (ISSN:09188959)
- 巻号頁・発行日
- vol.68, no.2, pp.171-177, 2021 (Released:2021-02-28)
- 参考文献数
- 21
- 被引用文献数
- 2
Recent randomized controlled studies have revealed that levothyroxine (LT4) treatment improves pregnancy outcomes only in infertile women with subclinical hypothyroidism who have thyroid autoantibodies (TAs), but not for those with high TSH levels within the normal range who have TAs. Here, we retrospectively investigated pregnancy outcomes in infertile Japanese women with 2.5 μIU/mL ≤ TSH < upper reference limit (URL). Between 2012 and 2018, 286 patients diagnosed with infertility were followed for more than 1 year at our institution. Among them, we included 106 patients with 2.5 μIU/mL ≤ TSH < URL. We divided these patients into four groups based on the combination of TA positivity and LT4 treatment status to assess the effects of LT4 treatment considering TA positivity on the incidence of pregnancy or miscarriage. In this study, we did not find any significant differences in the rates of pregnancy or miscarriage among the four groups (p = 0.81 and 0.52, respectively). In addition, logistic regression analysis showed that age and history of miscarriage were associated with the incidence of pregnancy, but presence of TAs and LT4 treatment status were not and that no variables examined were associated with the incidence of miscarriage. In summary, we were not able to demonstrate the benefit of LT4 treatment for pregnancy outcomes in Japanese euthyroid infertile women with 2.5 μIU/mL ≤ TSH < URL regardless of TA status in this study.
- 著者
- YUKA HONDA MITSUYOSHI SUZUKI YUICHI SATO KEIJI KURODA HIROMICHI SHOJI TOSHIAKI SHIMIZU
- 出版者
- The Juntendo Medical Society
- 雑誌
- 順天堂醫事雑誌 (ISSN:21879737)
- 巻号頁・発行日
- vol.62, no.2, pp.153-159, 2016 (Released:2016-07-02)
- 参考文献数
- 30
- 被引用文献数
- 1
Objective: The aim of this study was to investigate the associations of anti-Müllerian hormone (AMH) levels with physique and 25-hydroxyvitamin D (25OH-D) levels in healthy women of reproductive age based on measurements of nutritional status and physical constitution.Materials and Methods: Subjects comprised 108 non-obese women (age range, 21-39 years) who underwent examination of their physique, blood biochemistry and nutritional state. For data analysis, subjects were first divided by age. AMH levels were grouped by serum 25OH-D concentration using Holick’s classification: deficiency, <30 ng/ml; and sufficiency, ≥30 ng/ml.Results: Mean levels were 25.2±8.4 ng/ml for serum 25OH-D and 4.9±2.4 ng/ml for AMH. Overall, 76 women (70.4%) were diagnosed with 25OH-D deficiency. Serum AMH levels were significantly lower in subjects with 25OH-D deficiency (4.5±2.5 ng/ml) than in those with 25OH-D sufficiency (5.7±1.9 ng/ml; p<0.01). Significant differences were seen in the frequency of subjects with 25OH-D deficiency and sufficiency between low AMH (<2.2 ng/ml) status and normal AMH (≥2.2 ng/ml)(16/17 [94.1%] vs. 1/17 [5.9%] for low AMH status; 60/91 [65.9%] vs.31/91 [34.1%] for normal AMH status, respectively; p<0.05). Independent predictors of serum AMH levels≥2.2 ng/ml were serum 25OH-D level (p<0.05) and age (p<0.05) according to binary logistic regression analysis.Conclusions: Decreased serum AMH level is associated with vitamin D deficiency, but is unrelated to physique state in this population.